Neutrophil CAPNS1 regulates cardiac inflammation and injury by promoting NETosis in CVB3-induced myocarditis [0.03%]
中性粒细胞CAPNS1通过促进CVB3诱导的心肌炎中的NETosis来调节心脏炎症和损伤
Yucheng Wang,Jun Chen,Sijia Yu et al.
Yucheng Wang et al.
Exploring the immune mechanisms underlying Coxsackievirus B3 (CVB3)-induced myocarditis is critical for developing effective therapies, and the calpain small subunit 1 (CAPNS1) has emerged as a key regulator of inflammatory and immune respo...
L-Se-methylselenocysteine alleviates iron deposit-induced anxiety- and depression-like behaviors in chronic renal failure rats receiving iron therapy via Nrf2/GPX4 activation [0.03%]
L-硒甲基半胱氨酸通过激活Nrf2/GPX4减轻铁治疗慢性肾衰竭大鼠中铁沉积引起的类似焦虑和抑郁的行为
Fan Li,Siyao Liu,Yanyan Zhu et al.
Fan Li et al.
Objective: Iron supplements are routinely administered for renal anemia in patients with end-stage renal disease (ESRD). However, the association between cerebral iron overload and neuropsychiatric symptoms in this patien...
Beyond Antioxidants: How ROS-RNS-RSS Microdomains Encode Redox Information in Health and Disease [0.03%]
超越抗氧化物：ROS-RNS-RSS微域在健康和疾病中如何编码氧化还原信息
José Manuel Pérez de la Lastra,Celia María Curieses Andrés,Elena Bustamante Munguira et al.
José Manuel Pérez de la Lastra et al.
Cellular redox biology is governed less by bulk oxidant load than by coupled ROS, RNS, and RSS behaviour within spatially restricted microdomains. Within these niches, redox information is written, edited, and erased through competing post-...
Acox1 induces lipid peroxidation and metabolic shifting to promote PASMCs proliferation in hypoxia-induced pulmonary hypertension [0.03%]
Acox1诱导脂质过氧化和代谢转换以促进缺氧引起的肺动脉高压中的平滑肌细胞增殖
Qi Liang,Ying Wang,Xiaoliang Zhang et al.
Qi Liang et al.
Pulmonary hypertension (PH) is a progressive lethal disease, which is characterized by apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). The metabolic shifting is a hallmark of the PH and has been...
OXCT1-induced Succinylation at K81 Shields HADH from HSPA8-Mediated Degradation in alveolar epithelial cells to Attenuate Lung Ischemia-Reperfusion Injury [0.03%]
OXCT1诱导的乙酰辅酶A脱氢酶K81位点琥珀酰化使HADH免于HSPA8介导的降解以减轻肺缺血再灌注损伤
Jiwei Li,He Guan,Peng Miao et al.
Jiwei Li et al.
Lung transplantation serves as a life-saving therapeutic intervention for patients with end-stage pulmonary diseases, with the lung ischemia-reperfusion injury (LIRI) as the major challenge. Correcting lipid metabolic dysregulation in alveo...
Brazilin and its oxidized form "brazilein", the natural fluorescently traceable agents, toxify Plasmodium falciparum to pyknotic death via disrupting its iron homeostasis [0.03%]
巴西相和氧化产物巴西红相通过扰乱疟原虫铁代谢致其固缩死亡而发挥抗疟作用
Mattapong Kulaphisit,Wannakan Jaikamlue,Natnapa Jaitan et al.
Mattapong Kulaphisit et al.
A paradigm shift from malaria prevention to eradication requires more effective drug discovery. To cope with the emergence of anti-malarial drug resistance, screening for novel mode (s) of mechanism against Plasmodium falciparum (Pf) is ind...
Personalized antioxidant supplementation improves muscle strength, physical activity, and quality of life in patients with FSHD1: A real-world longitudinal study [0.03%]
个性化抗氧化补剂改善FSHD1患者的肌肉力量、身体活动和生活质量：一项真实世界纵向研究
Dalila Laoudj-Chenivesse,Sandrine Arbogast,Eric Raynaud De Mauverger et al.
Dalila Laoudj-Chenivesse et al.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy characterized by progressive muscle weakness. Oxidative stress plays a central role in its pathogenesis. This longitudinal, real-world study evaluated the effec...
CoQ0 hysteresis and inhibition of the cytochrome b5 reductase activity of human Cb5R by CoQ0 and CoQ10 [0.03%]
辅酶Q0对人细胞质型细胞色素b5还原酶的回滞效应及辅酶Q0和辅酶Q10对其细胞色素b5还原酶活性的抑制作用
Gabriel N Valerio,Oscar H Martinez-Costa,Carlos Sanchez-Cabeza et al.
Gabriel N Valerio et al.
Background: In this study, the effect of ubiquinone (CoQ10) and its soluble analogue (CoQ0) was measured on the NADH:Cb5 reductase activity of recombinant human membrane and soluble Cb5R, respectively using soluble Cb5 as...
Sex and photoperiod shape hepatic redox homeostasis in diet-induced obesity in association with a melatonin-NRF2-circadian regulatory axis [0.03%]
性激素和光周期通过褪黑素-NRF2-昼夜节律调节轴影响肥胖小鼠的肝脏氧化还原平衡
Aina Gironès-Garreta,Saioa Gómez-Roncal,Alba García-Aranda et al.
Aina Gironès-Garreta et al.
Obesity is associated with hepatic oxidative stress, metabolic dysregulation, and altered circadian regulation. Although both sex and photoperiod influence redox homeostasis, their combined impact in obesity remains insufficiently understoo...
Systemic lipid remodeling associated with deferoxamine treatment, dietary intervention and combinatorial effect in ameliorating high cholesterol diet-induced steatotic liver in mice [0.03%]
去铁胺治疗、饮食干预及其联合效应改善小鼠高胆固醇饮食诱导的肝脂变的系统性脂质重塑作用
Zhen Ni,Raoxu Wang,Huan Miao et al.
Zhen Ni et al.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming increasingly more prevalent and poses a major growing health concern worldwide. Iron deposition have been observed in the liver of...