Semaglutide ameliorates traumatic sepsis-induced cardiac injury by activating the March5-ACSL4 axis to suppress ferroptosis [0.03%]
司美格鲁肽通过激活March5-ACSL4轴抑制铁死亡从而改善创伤性脓毒症诱导的心脏损伤
Baisheng Sun,Lingxin Liu,He Zhang et al.
Baisheng Sun et al.
Post-traumatic septic myocardial dysfunction (PT-SIMD) is a life-threatening condition with high mortality and no specific treatment. Ferroptosis, an iron-dependent regulated cell death pathway driven by lipid peroxidation, has been implica...
Iron accumulation drives radiation-induced proctopathy via VDR/YAP signaling [0.03%]
铁沉积通过VDR/YAP信号传导驱动放射诱导的结肠炎
Xueyan Li,Wenzhi Tu,Yong Liu
Xueyan Li
Radiation proctopathy is a severe dose-limiting complication of pelvic radiotherapy that lacks effective interventions. Here, we investigate whether iron accumulation contributes to radiation-induced rectal fibrosis and elucidate the underl...
Succinylation of TAGLN2 at K40 drives lipid oxidative stress resistance and TMZ chemoresistance via redox reprogramming in Glioblastoma [0.03%]
胶质母细胞瘤中TAGLN2的K40琥珀酰化通过氧化还原重构驱动脂质氧化应激抵抗和TMZ耐药性
Wanyao Meng,Yayun Feng,Yuanyuan Huang et al.
Wanyao Meng et al.
Temozolomide (TMZ) resistance constitutes a primary cause of clinical treatment failure in glioblastoma (GBM). Targeting oxidative cell death to reverse glioma chemoresistance has emerged as a promising novel therapeutic strategy, whereas t...
Edaravone Attenuates Carbonyl-Stress-Driven ApoA-I Carboxymethylation and Macrophage Cholesterol-Handling Dysfunction in Diabetic Atherosclerosis [0.03%]
依达拉奉减轻糖尿病动脉粥样硬化中羰基应激驱动的载脂蛋白a-i碳甲基化和巨噬细胞胆固醇处理功能障碍
Hao-Cheng Ma,Yong-Xuan Xu,Zhuo-Rui Zhang et al.
Hao-Cheng Ma et al.
Diabetes increases atherosclerotic risk significantly, yet the molecular mechanisms linking diabetes-associated carbonyl stress to HDL dysfunction remain insufficiently defined. This study delineated a glyoxal-ApoA-I pathway in diabetes-ass...
The Metabolite indole-3-acetic acid of Bacteroides ovatus ameliorates ovariectomy-induced bone loss by activating AhR and inhibiting oxidative stress [0.03%]
脱氧核糖核酸菌卵酰亚胺-3-乙酸通过激活芳烃受体和抑制氧化应激缓解卵巢切除引起的骨质流失
Peng Cui,Haojie Zhang,Tao Hu et al.
Peng Cui et al.
Postmenopausal osteoporosis represents a systemic skeletal condition distinguished by diminished bone mass and heightened skeletal fragility. Emerging evidence has highlighted a significant relationship between bone metabolism and disturban...
VBIT-4 attenuates diabetes-associated cardiovascular mitochondrial dysfunction and ROS production in a mouse model of diabetes and hyperlipidemic cellular assays [0.03%]
基于糖尿病和高脂血症的小鼠模型及细胞损伤模型研究VBIT-4对糖尿病相关心血管线粒体功能障碍和ROS产生的缓解作用
Konstantin N Belosludtsev,Anna I Ilzorkina,Dmitriy A Khurtin et al.
Konstantin N Belosludtsev et al.
Mitochondrial dysfunction and oxidative stress are primary cellular factors in the development of diabetes mellitus and its associated cardiovascular complications. Targeting these processes represents a potential therapeutic strategy. Volt...
Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress [0.03%]
三氯蔗糖通过线粒体核糖体蛋白L12介导的线粒体核糖体应激促进心脏氧化代谢重塑
Ying Sun,Hualing Zhai,Junxue Wang et al.
Ying Sun et al.
Mitochondrial redox imbalance and defective oxidative phosphorylation are central features of lipotoxic cardiac injury, but whether diet-related chemical exposures perturb cardiomyocyte mitochondrial gene-expression machinery remains unclea...
Heat stress promotes myocardial injury and ventricular arrhythmia through DRP1-mediated mitochondrial dysfunction [0.03%]
热应激通过DRP1介导的线粒体功能障碍促进心肌损伤和室性心律失常
Jie Xiang,Jiang Han,Jiaru Cao et al.
Jie Xiang et al.
Background: With global warming, extreme summer heat has led to a higher morbidity and mortality of heat stroke (HS). Although heat stress has been linked to arrhythmias and cardiomyocyte injury, the specific molecular me...
Decyl-riboflavin: membrane-targeted lipophilic photosensitizer for lipid peroxidation and phototoxicity in HeLa cells under blue light irradiation [0.03%]
癸基核黄素：一种膜定位长脂溶性光敏剂，用于蓝光照射下HeLa细胞中的脂质过氧化和光毒性作用
Carlos A Ardila Padilla,M Sol Uribe Mayor,Macarena Dillon et al.
Carlos A Ardila Padilla et al.
Photodynamic therapy (PDT) exploits the controlled generation of reactive species to selectively destroy target cells, offering a minimally invasive alternative to conventional cancer and antimicrobial treatments. A key determinant of PDT e...
A multifunctional injectable hydrogel co-delivering GDF6 and MnO2 nanozymes alleviates intervertebral disc degeneration by mitigating oxidative stress and promoting anabolic repair [0.03%]
一种多用途可注射水凝胶联合递送GDF6和MnO2纳米酶，通过减轻氧化应激和促进合成代谢修复来缓解椎间盘退变
Chao Wei,Qin Tang,Yanlin Tan et al.
Chao Wei et al.
Intervertebral disc degeneration (IDD) is a primary cause of low back pain, characterized by cell loss, extracellular matrix (ECM) degradation, and a harsh microenvironment with excessive oxidative stress, creating an urgent need for regene...