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Se-methylselenocysteine induces NRF2-ATF4 stress signaling and ferroptosis-associated remodeling in pancreatic cancer

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Pancreatic ductal adenocarcinoma (PDAC) is characterized by profound resistance to therapy, driven in part by its capacity to adapt to oxidative, metabolic, and proteotoxic stress. In this study, we investigated how the redox-active selenium compound Se-methyl... ...