Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation
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The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactivation. The flavin-co... ...
