Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation [0.03%]
撤稿：体内NCL靶向通过miRNA调节影响乳腺癌的恶性程度
Flavia Pichiorri,Dario Palmieri,Luciana De Luca et al.
Flavia Pichiorri et al.
Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models [0.03%]
基于间皮素的CAR-T细胞靶向MUC16有效控制膀胱癌的预临床模型研究
Parwiz Abrahimi,Jonathan F Khan,Alyssa Duren-Lubanski et al.
Parwiz Abrahimi et al.
Intravesical therapies are the mainstay of bladder cancer (BCa) management, but their efficacy is limited by toxicities and recurrences. While CAR T cell therapy has shown promise in hematologic malignancies, its application in solid tumors...
Seren Baygün,Marc Schmidt-Supprian
Seren Baygün
B-T cell cross talk is safeguarded by central and peripheral tolerance and cell-intrinsic checkpoints. In this issue of JEM, Lin et al. (https://doi.org/10.1084/jem.20251968) show that altered translation in early germinal center B cells tr...
Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated [0.03%]
纠正：LCK缺陷：LCK先天性免疫缺陷揭示了如何校准TCR信号传导
Ahmet Eken,Sara A Johnson,Serife Erdem et al.
Ahmet Eken et al.
Marcin Krzysztof Maniak,Stephen J Jenkins,Carsten Gram Hansen
Marcin Krzysztof Maniak
Mechanical forces are increasingly recognized as potent regulators of inflammation. Physical cues such as stretch, tissue stiffness, and shear stress shape innate immune responses across barrier epithelia, stromal niches, and the vascular e...
Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis [0.03%]
胆汁酸在efferocytic巨噬细胞中的滞留可调节其在胆管炎期间的炎症状态
Amirah Al Jawazneh,Imke Liebold,Stephanie Leyk et al.
Amirah Al Jawazneh et al.
The clearance of apoptotic cells by phagocytes is crucial for restoring tissue balance after injury. In autoimmune liver diseases like primary sclerosing cholangitis, cell death is thought to result from accumulation of toxic bile acids wit...
Endothelial cells notch monocytes toward an alveolar macrophage fate [0.03%]
内皮细胞使单核细胞倾向于肺泡巨噬细胞命运方向转变
Stijn Verwaerde,Bart N Lambrecht,Martin Guilliams
Stijn Verwaerde
Mínguez-Martínez et al. (https://doi.org/10.1084/jem.20242085) identify a cooperative RBPJ-STAT5-SMAD4-RXRα-PPARγ transcriptional network that integrates DLL4, GM-CSF, and TGFβ signals to establish alveolar macrophage identity. Their f...
Li Zhong,Hua Gu
Li Zhong
Long-term maintenance of immune memory is critical for the control of recurring virus infections and cancer. In this issue of JEM, Ma et al. (https://doi.org/10.1084/jem.20252687) report that the E2 ubiquitin-conjugating enzyme UBE2F restra...
The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells [0.03%]
IRF8介导的CD8+t细胞胞内酸中毒导致肿瘤特异性免疫耗竭
Marco Ongaro,Romane Thouenon,Isaac Crespo et al.
Marco Ongaro et al.
T cell exhaustion is a major obstacle to effective immunotherapy in cancer and chronic infection. Here, we identify the transcription factor IRF8 as a tumor-specific regulator of CD8+ T cell exhaustion. IRF8 is strongly expressed in tumor-r...
Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells [0.03%]
细胞因子白介素-12通过STAT4-DDX5信号轴调控自然杀伤细胞转录起始复合物的动态组装机制研究
Hyunu Kim,Simon Grassmann,Wilfred Wong et al.
Hyunu Kim et al.
Natural killer (NK) cells are innate lymphocytes that rapidly respond to inflammatory cytokines during infection, but the mechanisms underlying such swift responses remain incompletely understood. Here, we investigated the RNA polymerase II...