In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation [0.03%]
体内CRISPR/Cas9筛选鉴定出新的B细胞活化和浆细胞分化调控因子
Lesly Calderón,Markus Schäfer,Marina Rončević et al.
Lesly Calderón et al.
Immune responses to pathogens lead to the generation of plasma cells through a complex interplay of B cells with their microenvironment in lymphoid organs. To identify new regulators of B cell activation and plasmablast differentiation in t...
Amir Ghorbani,Jonathan W Yewdell
Amir Ghorbani
In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20250025) describe complete T cell antigens (CTAs), comprised of class I and class II immunogenic peptides fused in a single polypeptide that greatly increase the effectiveness...
Correction: Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology [0.03%]
纠正：单细胞和空间分析揭示了TB诱导的肌成纤维细胞是肺部疾病的驱动因素
Ian M Mbano,Nuo Liu,Marc H Wadsworth nd et al.
Ian M Mbano et al.
Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers [0.03%]
纠正：优势负ADA2突变导致杂合子携带者ADA2缺乏
Marjon Wouters,Lisa Ehlers,Wout Van Eynde et al.
Marjon Wouters et al.
Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology [0.03%]
单细胞和空间转录组揭示巨噬细胞在肺纤维化中的关键作用
Ian M Mbano,Nuo Liu,Marc H Wadsworth nd et al.
Ian M Mbano et al.
Tuberculosis (TB) typically causes lung destruction and fibrosis, leading to ∼1.3 million deaths annually. The cellular drivers of human TB immunopathology remain poorly defined. We performed single-cell RNA sequencing and spatial transcri...
Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance [0.03%]
Claudin 1介导的DC1向mTEC定位对于中枢耐受维持是必需的
Jiří Březina,Tomáš Brabec,David Machač et al.
Jiří Březina et al.
Central tolerance, which relies on the presentation of self-antigens by mTECs and DCs, prevents autoimmunity by eliminating self-reactive T cells. While mTECs produce self-antigens autonomously, DCs acquire them from mTECs via cooperative a...
FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells [0.03%]
Foxo1双重组酶等位基因的重新表达可挽救生发中心B细胞的类别转换反应
Carlota Farré Díaz,Eleni Kabrani,Wiebke Winkler et al.
Carlota Farré Díaz et al.
Modeling complex (patho)physiological processes by sequential targeted mutagenesis in mice is limited by the lack of precision of cellular targeting and complex breeding strategies. We present a new Cre/DreERT2 dual-recombinase germinal cen...
Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones [0.03%]
HIV-1在真正的潜伏CD4+T细胞克隆中的转录是异质的
Cintia Bittar,Ana Rafaela Teixeira,Thiago Y Oliveira et al.
Cintia Bittar et al.
Antiretroviral therapy suppresses HIV-1 infection but fails to eliminate a reservoir of intact latent proviruses that reside primarily in CD4+ T cells. The lack of precise understanding of the latent compartment has made it challenging to d...
Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging [0.03%]
人类血液生成分子和表型蓝图将增殖压力与干细胞老化联系起来
Emanuele Lettera,Luca Basso-Ricci,Edoardo Carsana et al.
Emanuele Lettera et al.
Hematopoietic stem/progenitor cells (HSPC) aging has long been associated with myeloid skewing, reduced clonal output, and impaired regenerative capacity, but quantitative immunophenotypic and functional analysis across the human lifespan h...
Collin J Laaker,Sophia M Vrba,Jenna M Port et al.
Collin J Laaker et al.
Olfactory nerve bundles exit the brain through the cribriform plate (CP) with a rich perineural microenvironment (cpPME). This microenvironment facilitates interactions between cerebrospinal fluid, blood vessels, bone marrow, and lymphatic ...