Mínguez-Martínez et al. (https://doi.org/10.1084/jem.20242085) identify a cooperative RBPJ-STAT5-SMAD4-RXRα-PPARγ transcriptional network that integrates DLL4, GM-CSF, and TGFβ signals to establish alveolar macrophage identity. Their findings position end... ...

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