Dusan Bogunovic
Dusan Bogunovic
Humans are disomic. At birth, all nucleated cells in the body have the same genetic material, composed of 22 pairs of autosomes and a pair of sex chromosomes. Half the chromosomes are maternal, and half are paternal. It is thought that the ...
Fares Bassil,Emily S Meymand,Hannah J Brown et al.
Fares Bassil et al.
Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke [0.03%]
缺血后诱导型蛋白HIP-2介导Ly6ChighLy6Glow单核细胞的代谢重编程
Weijie Chen,Xin Wang,Tingting Huang et al.
Weijie Chen et al.
Ly6Chigh monocytes, previously recognized as a pro-inflammatory subset, play critical roles in secondary neuroinflammation in the stroke brain. Growing evidence reveals increased infiltration of myeloid cells with substantial heterogeneity,...
Maria Nogales-Pons,Mariola Munárriz-Paños,Teresa Aceña-Gonzalo et al.
Maria Nogales-Pons et al.
Myeloid cells are present in neoplastic tissues from the earliest stages of transformation through to fully developed tumors. However, their intrinsic dynamism and plasticity make them difficult to target therapeutically. Emerging technolog...
Macrophage anti-bacterial activity is controlled by adenylate kinase 4-mediated mitochondrial DNA synthesis [0.03%]
腺苷酸激酶4介导的线粒体DNA合成调控巨噬细胞抗菌活性
Wei-Yao Chin,Ching-Tung Wu,Gunn-Guang Liou et al.
Wei-Yao Chin et al.
Macrophage antibacterial activity requires mtROS production. The specific gene(s) that participates in the mtROS-mediated antibacterial process remains unclear. We showed that Listeria and Salmonella infections in human and mouse macrophage...
Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA [0.03%]
通过内源性内含子双链RNA介导的抗病毒反应抑制作用研究 интроны Recycling缺陷通过一种内在端ogenous dsRNA机制抑制抗病毒反应
Chaorui Duan,Luke Buerer,Cory Bowers et al.
Chaorui Duan et al.
Loss of the lariat debranching enzyme DBR1 causes cytoplasmic accumulation of intron lariats, but why this reduces cell-intrinsic immunity is unclear. Here, we show that intronic inverted repeats Alu (IR Alus), normally degraded after splic...
The STING HAQ haplotype and clinical non-penetrance in COPA syndrome [0.03%]
COPA综合征中的STING HAQ基因型与临床表现不完全外显性关系的研究
Clémence David,Tifenn Wauquier,Alix de Becdelièvre et al.
Clémence David et al.
COPA syndrome is a rare monogenic autoinflammatory disease due to heterozygous mutations in COPA, encoding the coatomer subunit α. COPA syndrome demonstrates phenotypic overlap with STING-associated vasculopathy with onset in infancy (SAVI...
Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes [0.03%]
GPR183感应代谢信号促进单核细胞填充肺巨噬细胞生态位
Laura Bub,Elza Evren,Stijn Verwaerde et al.
Laura Bub et al.
Monocytes populate tissues when local niches are depleted of tissue-resident macrophages, yet the tissue-derived signals controlling monocyte-to-macrophage differentiation are largely undefined. Here, we discovered that the oxysterol recept...
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment [0.03%]
炎症通过神经源性单核细胞募集重新连接肠神经系统
Sravya Kurapati,Changsik Shin,Krisztina Szabo et al.
Sravya Kurapati et al.
Proper organization of the enteric nervous system (ENS) is critical for normal gastrointestinal (GI) physiology. Inflammatory bowel disease (IBD) disrupts key GI functions, including bowel motility. However, in many IBD patients, motility d...
Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens [0.03%]
免疫谱分析将自身免疫性肝炎与人类疱疹病毒6和松弛素受体抗原联系起来
Arielle Klepper,James Asaki,Colette M Caspar et al.
Arielle Klepper et al.
Autoimmune hepatitis (AIH) is a severe, chronic disease where IgG elevation and autoantibody profile are defining features. However, linking autoantibodies to AIH pathogenesis remains elusive. We employed phage-display immunoprecipitation s...