Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted [0.03%]
通过扩大靶向CSP区域来克服疟疾亚单位疫苗的免疫原性缺口
Ja-Hyun Koo,Prabhanshu Tripathi,Yevel Flores-Garcia et al.
Ja-Hyun Koo et al.
The first approval of malaria vaccines RTS,S/AS01 and R21/Matrix M marked a major milestone. Both vaccines present a portion of the Plasmodium falciparum circumsporozoite protein (PfCSP) containing an immunodominant major repeat region, whi...
Melissa Cipolla,Andrew J MacLean,Brianna Hernandez et al.
Melissa Cipolla et al.
Immune memory responses are rapid and qualitatively distinct from primary responses. They typically develop in the presence of antigen-experienced memory T and B cells and preexisting antibodies. Although the contribution of T and B cells t...
Emerging insights into TL1A biology may guide precision therapy for IBD [0.03%]
TL1A生物学的最新见解可能有助于指导IBD的精准治疗
Silvia Pires,Wei Yang,Randy S Longman
Silvia Pires
Therapeutic blocking antibodies against TNF-like cytokine 1A (TL1A) are emerging as one of the most compelling targets in inflammatory bowel disease (IBD). Preliminary phase 2 studies using TL1A-blocking antibodies have demonstrated some of...
SorLA regulates B cell receptor uptake, trafficking, and B cell-mediated immune responses in vivo [0.03%]
SorLA调节体内B细胞受体的摄取、转运及B细胞介导的免疫应答
Melibea Berzosa,Adam N McShane,Anna E Kliszczak et al.
Melibea Berzosa et al.
A high-affinity antibody response to both infection and vaccination critically relies on the ability of B cells to capture and process antigen for presentation to CD4+ T cells. The cellular processes from antigen recognition to full B cell ...
Correction: CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors [0.03%]
校正：CD55调节子宫内膜样肿瘤的自我更新和顺铂耐药性
Caner Saygin,Andrew Wiechert,Vinay S Rao et al.
Caner Saygin et al.
Antibody-drug conjugates in solid tumors: Efficacy, challenges, and opportunities [0.03%]
抗体偶联药物在实体瘤中的疗效、挑战及机遇
Nakul M Shah,Funda Meric-Bernstam
Nakul M Shah
Antibody-drug conjugates (ADCs) have become an increasingly important component of the therapeutic landscape of many solid tumors. Currently, there are eight ADCs approved for solid tumors, with hundreds being developed and in clinical tria...
Addendum: RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions [0.03%]
附注：RAF/MEK/细胞外信号调节激酶途径抑制树突状细胞迁移并使朗格汉斯细胞组织细胞增生症病灶中树突状细胞滞留
Brandon Hogstad,Marie-Luise Berres,Rikhia Chakraborty et al.
Brandon Hogstad et al.
A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair [0.03%]
一种神经和肥大细胞警卫系统释放胞外凝聚物诱导巨噬细胞修复
Lilian Salm,Monica Aida Lopez,Edward Jenkins et al.
Lilian Salm et al.
There is a higher density of immune cells in peritoneal fluid than is found in blood. Thus, any perturbations, from sterile injury to endometriosis to ovarian cancer, require immune cells to recognize and nucleate to these sites. Using peri...
Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection [0.03%]
组织型纤溶酶原激活物可预防侵袭性真菌感染所致的肾脏损伤
Wonseok Choi,Doureradjou Peroumal,Colin T McLaughlin et al.
Wonseok Choi et al.
Invasive Candida albicans infections (candidiasis) cause progressive organ damage through fungal tissue invasion and toxin-mediated injury, including in the kidney. Hyphal invasion induces apoptosis of renal tubular epithelial cells (RTEC),...
Michail S Lionakis
Michail S Lionakis
IL-17 is well-recognized for orchestrating mucosal antifungal immunity. In this issue of JEM, Choi et al. (https://doi.org/10.1084/jem.20260530) identify a downstream tPA-LRP1 axis that safeguards the renal epithelium during systemic candid...