Lung tissue-resident memory T cells optimize protection by IL-10 regulation of innate immunity [0.03%]
肺组织驻留记忆T细胞通过IL-10调节固有免疫来优化保护作用
Alexander Y Yang,Julia Davis-Porada,Daniel H Paik et al.
Alexander Y Yang et al.
Respiratory viral infections establish tissue-resident memory T cells (TRM) in the lung, which provide optimal protection against subsequent infections, though the underlying mechanisms are incompletely understood. Here, we demonstrate in a...
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1 [0.03%]
腺苷代谢清除通过精氨酸甲基化RIPK1维持肝脏稳态
Ran Liu,Gengqiao Wang,Zhengting Jiang et al.
Ran Liu et al.
Tumor necrosis factor α (TNFα) maintains homeostasis through promoting cell survival or cell death; however, how this process is regulated by metabolic pathways remains largely unknown. Here, we identify adenosine kinase (ADK), the key en...
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2 [0.03%]
普通感冒嵌合冠状病毒的表位印记促进对SARS-CoV-2 S2区的广谱中和抗体反应
Siriruk Changrob,Atsuhiro Yasuhara,Suncheol Park et al.
Siriruk Changrob et al.
The S2 subunit of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is highly conserved across coronavirus strains and therefore is a potential pan-coronavirus vaccine target. However, antibodies targeting this region a...
Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity [0.03%]
NF-κB在复制人类固有免疫异常的小鼠HSV脑炎发病机制中的作用
Manja Idorn,Xiangning Ding,Stefanie Fruhwürth et al.
Manja Idorn et al.
Herpes simplex encephalitis (HSE) is a devastating disease with high mortality and serious sequelae. Genetic defects in the IFN-I pathway predispose individuals to HSE, but underlying mechanisms remain unclear. Using transgenic mice with th...
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity [0.03%]
微卫星不稳定肿瘤通过上调TREX1逃避免疫监视
Yan Xu,Zheqi Zhou,Wenzheng Chen et al.
Yan Xu et al.
Currently, it remains largely unclear how MSI-H/dMMR tumors, despite heightened immune pathway activation and antigenic mutation accumulation, evade immune elimination and promote tumorigenesis. Our study showed that dMMR tumors accumulate ...
CD2 and its ligands are involved in development and activation of MAIT cells [0.03%]
CD2及其配体参与MAIT细胞的发育和激活
Kaiwen Zhu,Jiayu Dou,Bin Li et al.
Kaiwen Zhu et al.
MAIT cells are innate-like T cells known for their semi-invariant TCR that recognizes vitamin B metabolites presented by MR1. While the involvement of TCR and cytokines in development and activation of MAIT cells is well documented, the con...
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice [0.03%]
RIPK1 S161磷酸化促进TNF处理小鼠中RIPK1自身磷酸化以及盲肠坏死性凋亡
Tao Han,Chenchen Ruan,Huiyong Lin et al.
Tao Han et al.
Excess TNF causes systemic inflammatory response syndrome and mortality. RIPK1 coordinates TNF signaling through kinase-dependent and -independent mechanisms. S161 autophosphorylation is a primary function of RIPK1 kinase activity in vitro,...
RIPK1 autophosphorylation at S161 mediates cell death and inflammation [0.03%]
RIPK1的S161自磷酸化介导细胞死亡和炎症反应
Lioba Koerner,Xiaoming Li,Eveline Silnov et al.
Lioba Koerner et al.
RIPK1 regulates cell death and inflammation and has been implicated in the pathogenesis of inflammatory diseases. RIPK1 autophosphorylation promotes cell death induction; however, the underlying mechanisms and the role of specific autophosp...
Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses [0.03%]
人CD4⁺T细胞识别受结核杆菌感染的巨噬细胞并在更广泛的反应中产生应答
Volodymyr Stetsenko,Daniel P Gail,Scott M Reba et al.
Volodymyr Stetsenko et al.
CD4+ T cell-mediated control of tuberculosis (TB) requires recognition of macrophages infected with Mycobacterium tuberculosis (Mtb). Yet, not all Mtb-specific T cells recognize infected macrophages. Using infected monocyte-derived macropha...
Type I IFN drives neutrophil swarming, impeding lung T cell-macrophage interactions and TB control [0.03%]
I型干扰素驱动中性粒细胞聚集，妨碍肺T细胞-巨噬细胞相互作用和结核病控制
William J Branchett,Evangelos Stavropoulos,Jessica Shields et al.
William J Branchett et al.
The early immune mechanisms determining Mycobacterium tuberculosis infection outcome are unclear. Using bulk and scRNA-seq over the first weeks of infection, we describe an unexpected, higher early pulmonary type I IFN response in relativel...