Antibody-drug conjugates in solid tumors: Efficacy, challenges, and opportunities [0.03%]
抗体偶联药物在实体瘤中的疗效、挑战及机遇
Nakul M Shah,Funda Meric-Bernstam
Nakul M Shah
Antibody-drug conjugates (ADCs) have become an increasingly important component of the therapeutic landscape of many solid tumors. Currently, there are eight ADCs approved for solid tumors, with hundreds being developed and in clinical tria...
Addendum: RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions [0.03%]
附注：RAF/MEK/细胞外信号调节激酶途径抑制树突状细胞迁移并使朗格汉斯细胞组织细胞增生症病灶中树突状细胞滞留
Brandon Hogstad,Marie-Luise Berres,Rikhia Chakraborty et al.
Brandon Hogstad et al.
A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair [0.03%]
一种神经和肥大细胞警卫系统释放胞外凝聚物诱导巨噬细胞修复
Lilian Salm,Monica Aida Lopez,Edward Jenkins et al.
Lilian Salm et al.
There is a higher density of immune cells in peritoneal fluid than is found in blood. Thus, any perturbations, from sterile injury to endometriosis to ovarian cancer, require immune cells to recognize and nucleate to these sites. Using peri...
Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection [0.03%]
组织型纤溶酶原激活物可预防侵袭性真菌感染所致的肾脏损伤
Wonseok Choi,Doureradjou Peroumal,Colin T McLaughlin et al.
Wonseok Choi et al.
Invasive Candida albicans infections (candidiasis) cause progressive organ damage through fungal tissue invasion and toxin-mediated injury, including in the kidney. Hyphal invasion induces apoptosis of renal tubular epithelial cells (RTEC),...
Michail S Lionakis
Michail S Lionakis
IL-17 is well-recognized for orchestrating mucosal antifungal immunity. In this issue of JEM, Choi et al. (https://doi.org/10.1084/jem.20260530) identify a downstream tPA-LRP1 axis that safeguards the renal epithelium during systemic candid...
Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2) [0.03%]
STAT2(TIMS2)基因突变导致的家族性肺泡蛋白沉积症和I型干扰素病
Conor Gruber,Meredith Ramba,Bineeta Debnath et al.
Conor Gruber et al.
Mutations that enhance type I interferon (IFN-I) activity cause monogenic autoinflammatory disorders termed type I interferonopathies. Along with the typical neurologic and rheumatologic manifestations, severe pulmonary disease is increasin...
Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis [0.03%]
罕见或常见的IL23R低功能纯合变异易患结核病
Diana Olguín Calderón,Laura E Kilpatrick,Clément Conil et al.
Diana Olguín Calderón et al.
Homozygosity for rare loss-of-function IL23R variants abolishes IL-23-dependent IFN-γ production by lymphocytes, including NK and innate-like T cells, thereby underlying clinical disease due to weakly virulent mycobacterial species. We rep...
ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype [0.03%]
ADAR1功能丧失型变异体改变RNA编辑定义了一种新的干扰素依赖型银屑病亚型
Florence Assan,Margot Tragin,Sahiti Marella et al.
Florence Assan et al.
Recent evidence implicates altered RNA editing and dysregulated type I IFN signaling in immune-mediated diseases, including psoriasis, although the underlying genetic mechanisms remain poorly defined. We investigated four unrelated multiple...
Both soluble and cell surface CD137 expressed by Foxp3+ CD4 T cells restrain autoimmune diabetes [0.03%]
Foxp3阳性CD4 T细胞所表达的可溶性和细胞表面CD137均能抑制自身免疫糖尿病
Rabia Nabi,Chien-Wei Lin,Yu Wang et al.
Rabia Nabi et al.
CD137 is expressed in a subset of Foxp3+ regulatory CD4 T cells (Tregs), but its immunoregulatory role is not fully defined. Due to alternative splicing that removes the transmembrane domain-encoding exon, CD137 exists in both membrane and ...
Aeson Chang,Shenghong Zhu,Terrance Lam et al.
Aeson Chang et al.
The nervous system has emerged as a critical regulator of cancer progression. Recent studies demonstrate that peripheral neurons shape tumor growth, dissemination, and therapeutic response by regulating multiple components of the tumor micr...