Spencer E Mirabile-Brightman,Lisa H Butterfield
Spencer E Mirabile-Brightman
The ability to specifically engage tumor-reactive T cells for therapeutic benefit is the ultimate goal of cancer immunotherapy. Whereas currently approved immunotherapies leverage and modulate existing endogenous T cells in an antigen non-s...
Paulina D Horton,Alina Syed,Michelle Winkler et al.
Paulina D Horton et al.
Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the ...
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis [0.03%]
REV-ERB通过Bhlhe40-c-Maf轴调节RORγt+调节性T细胞的谱系分化和功能
Xianting Hu,Zhi Liu,Yao Li et al.
Xianting Hu et al.
Foxp3+ regulatory T (Treg) cells co-expressing RORγt adopt specialized functions to restrain intestinal inflammation. However, despite extensive characterization, the factors governing RORγt+Foxp3+ Treg specialization remain unclear. Here...
Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza [0.03%]
H5N1重症禽流感死亡病例中靶向I型干扰素的自身抗体
Qian Zhang,Taylor S Conrad,Marcela Moncada-Velez et al.
Qian Zhang et al.
Avian influenza A virus (IAV) H5N1 is an emerging threat of human pandemic. We describe a 71-year-old man who died of H5N1 pneumonia in Louisiana and whose blood contained autoantibodies neutralizing type I IFNs (AAN-I-IFNs), including the ...
Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis [0.03%]
具I型干扰素活性阻断作用自身抗体存在于重症单纯疱疹病毒性肝炎患者中
Adrian Gervais,Astrid Marchal,Soraya Boucherit et al.
Adrian Gervais et al.
Fulminant viral hepatitis (FVH) is a devastating condition caused by hepatotropic viruses such as hepatitis A virus (HAV), hepatitis B virus (HBV), and HSV-1/2. We studied 149 FVH patients (73 males and 76 females, aged 1-76) for blood auto...
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect [0.03%]
envelopes蛋白转运缺陷的猴免疫缺损病毒(SIV)变异体自然感染和药理学控制的动力学规律研究
Kyle Rhodehouse,Carolin Zitzmann,Meghana Ravi et al.
Kyle Rhodehouse et al.
Insights into HIV-1 pathogenesis have come from studies of viral dynamics. However, there is little information on viral dynamics in lentiviral infections in which viral replication is naturally controlled in a subset of infected individual...
Chimeric MHC class I- and II-restricted non-self epitopes broaden antitumor T cell reactions [0.03%]
嵌合的I类和II类非自身表位能扩大抗肿瘤T细胞反应
Rongsheng Zhang,Rong Ma,Merrin M L Leong et al.
Rongsheng Zhang et al.
The mechanism by which one non-self antigen augments T cell immune responses to another remains unclear. We found that these expanded immune responses could derive from chimeric non-self peptides. These peptides, which we termed complete T ...
Notch interaction with RUNX factors regulates initiation of the T-lineage program [0.03%]
诺特定时与RUNX因子相互作用可调节T细胞谱系程序的启动事件
Yuichi Kama,Ken-Ichi Hirano,Kaori Masuhara et al.
Yuichi Kama et al.
Runt-related transcription (RUNX) factors play a key role in T cell development. At the T-lineage commitment checkpoint, RUNX1 undergoes dynamic partner switching, resulting in its redeployment. Here, we investigated the functional differen...
SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases [0.03%]
SpeckSeq使MEFV变异在自身炎症性疾病中的功能分层成为可能
Pauline Bronnec,Sarah Dalmon,Chloe Briand et al.
Pauline Bronnec et al.
Variants of uncertain significance (VUS) are a major obstacle in genetic diagnosis, particularly when involving gain-of-function (GoF) mutations that are poorly predicted in silico. MEFV, which encodes the inflammasome sensor pyrin, is muta...
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance [0.03%]
XPR1调节胎儿肝巨噬细胞的发育、身份和处理皮红细胞的能力
Sebastian A Stifter,Mitchell Bijnen,Selma Tuzlak et al.
Sebastian A Stifter et al.
Inorganic phosphate (Pi) is an essential nutrient for all organisms. It has critical functions in lipid and nucleic acid synthesis, protein signaling and bone growth. Loss-of-function mutations in Pi transporters lead to embryonic and neona...