Sangwoo Park,Marcela V Maus
Sangwoo Park
Repeated tumor contact leaves more behind than simple CAR-T exhaustion. This study by Gu et al. (https://doi.org/10.1084/jem.20252564) shows that chronic antigen exposure impairs a Rab5-dependent endocytic program, allowing trogocytosed ant...
Mauricio Guzmán,Martyna Filipska,Andrea Cerutti
Mauricio Guzmán
In this issue, Luff et al. (https://doi.org/10.1084/jem.20251308) show that cell-intrinsic signals from TACI drive marginal zone B cell development from T2 B cells through a mechanism involving activation of the PI3K-AKT pathway and inhibit...
Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels [0.03%]
Rab5通过减少同种相溶和维持细胞表面CAR水平来提高CAR-T细胞的疗效
Meidi Gu,Kaitlin A Read,Vipin Bhardwaj et al.
Meidi Gu et al.
We show continuous tumor exposure results in a loss of chimeric antigen receptor (CAR) T cell (CART) endocytic activity due to downregulation of Rab5. Loss of endocytic activity exacerbates the effects of trogocytosis, the bidirectional tra...
Daisy H Luff,Lesley Vanes,Stefan Boeing et al.
Daisy H Luff et al.
The mature B cell compartment consists of follicular and marginal zone (MZ) B cells, which develop from transitional type 2 (T2) B cells. TACI, a member of the TNF receptor superfamily, is expressed on all mature B cells, with highest level...
LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated [0.03%]
LCK缺陷：LCK的先天性免疫缺陷揭示了如何校准TCR信号转导
Ahmet Eken,Sara A Johnson,Serife Erdem et al.
Ahmet Eken et al.
TCR signaling must be precisely calibrated to guide thymic selection, lineage commitment, and immune homeostasis. LCK, the dominant proximal Src-family kinase in T cells, functions as a volume dial governing initial TCR signal amplitude. Hu...
LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis [0.03%]
LINGO4调节ILC3固有的IL-22产生及微生物群介导的ILC3稳态
José L Fachi,Tihana Trsan,Cristiane Sécca et al.
José L Fachi et al.
LINGO4 is a leucine-rich repeat and immunoglobulin-like domain-containing transmembrane protein encoded immediately adjacent to Rorc, the gene for RORγt, raising the possibility that it contributes to the biology of RORγt+ lymphocytes. Ho...
Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection [0.03%]
肠细菌感染期间肠系膜巨噬细胞-单核细胞回路控制全身性炎症
Jiseon Kim,Joseph R Dominguez,Seung Hyeon Kim et al.
Jiseon Kim et al.
Although the gut mesentery is anatomically linked to the intestines, the roles of mesentery-resident macrophages and mesentery-recruited monocytes, particularly in gut inflammation, remain poorly defined. Here, we show that mesenteric macro...
BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism [0.03%]
BACH2通过PPARγ依赖性线粒体代谢控制ILC3功能
Jianye Wang,Ying Wang,Gaoyu Liu et al.
Jianye Wang et al.
Group 3 innate lymphoid cells (ILC3s) play an essential role in maintaining intestinal barrier immunity. Dysfunction of ILC3s contributes to the pathogenesis of inflammatory bowel disease (IBD), whereas the mechanisms underlying ILC3 regula...
Antibody-mediated diversification of primary and secondary humoral immune responses [0.03%]
抗体介导的初级和次级体液免疫反应的多样化
Dennis Schaefer-Babajew,Laurine Binet,Gabriela S Silva Santos et al.
Dennis Schaefer-Babajew et al.
Humoral immune responses are characterized by increasing antibody affinity and diversity over time. Increased affinity is mediated by a combination of immunoglobulin gene somatic mutation and iterative cycles of selection in germinal center...
Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype [0.03%]
Tet2缺陷可改变CD4+T细胞功能并促进具有TFH细胞免疫表型的T细胞淋巴瘤形成
Tayla B Heavican-Foral,Yuping Li,Waseem Lone et al.
Tayla B Heavican-Foral et al.
TET2 mutations are frequent in TFH-derived lymphomas, but how epigenetic disruption initiates malignant T cell transformation is unclear. We generated Cd4cre;Tet2FL/FL mice, which developed aggressive T cell lymphoma (m-TCL) with a TFH cell...