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Interferon-λ drives renal fibrosis by coordinating epithelial-fibroblast crosstalk

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Renal fibrosis is a critical step in chronic kidney disease (CKD) progression, but fibrosis induction is still not understood well. We found that IFN-λ is a profibrotic factor that is upregulated in fibrotic human and mouse kidneys. IFN-λ receptor deficiency... ...