Daniela C Soto,José M Uribe-Salazar,Gulhan Kaya et al.
Daniela C Soto et al.
Duplicated genes expanded in the human lineage likely contributed to brain evolution, yet challenges exist in their discovery due to sequence-assembly errors. We used a complete telomere-to-telomere genome sequence to identify 213 human-spe...
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia [0.03%]
功能性的肝脏基因组学鉴定出癌症恶病质消耗肝细胞激素促进作用
Doris Kaltenecker,Søren Fisker Schmidt,Peter Weber et al.
Doris Kaltenecker et al.
In cancer cachexia, the presence of a tumor triggers systemic metabolic disruption that leads to involuntary body weight loss and accelerated mortality in affected patients. Here, we conducted transcriptomic and epigenomic profiling of the ...
Identification and application of cell-type-specific enhancers for the macaque brain [0.03%]
识别和应用恒河猴大脑中细胞类型特异性增强子
Ling Li,Yiming Huang,Dengyu Lu et al.
Ling Li et al.
Published Erratum
Cell. 2025 Jul 21:S0092-8674(25)00815-3. DOI:10.1016/j.cell.2025.07.026 2025
In vivo prime editing rescues alternating hemiplegia of childhood in mice [0.03%]
体内prime编辑技术可拯救小鼠的儿童交替性偏瘫症状
Alexander A Sousa,Markus Terrey,Holt A Sakai et al.
Alexander A Sousa et al.
Alternating hemiplegia of childhood (AHC) is a neurodevelopmental disorder with no disease-modifying treatment. Mutations in ATP1A3, encoding an Na+/K+ ATPase subunit, cause 70% of AHC cases. Here, we present prime editing (PE) and base edi...
Cell-type-directed network-correcting combination therapy for Alzheimer's disease [0.03%]
针对阿尔茨海默病的细胞类型导向网络纠正型联合治疗
Yaqiao Li,Carlota Pereda Serras,Jessica Blumenfeld et al.
Yaqiao Li et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a ce...
Small RNAs are modified with N-glycans and displayed on the surface of living cells [0.03%]
小RNAs具有N-聚糖修饰并以细胞表面蛋白形式展示
Ryan A Flynn,Kayvon Pedram,Stacy A Malaker et al.
Ryan A Flynn et al.
Published Erratum
Cell. 2025 Jul 21:S0092-8674(25)00808-6. DOI:10.1016/j.cell.2025.07.019 2025
Regulation of inflammatory responses by pH-dependent transcriptional condensates [0.03%]
由pH值依赖的转录凝聚物介导的炎症反应调节
Zhongyang Wu,Scott D Pope,Nasiha S Ahmed et al.
Zhongyang Wu et al.
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation is monitored remains largely unknown. Acidification of the tissue microenvironment is ass...
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1 [0.03%]
MCT8和OATP1C1转运甲状腺激素进入大脑的结构洞察
Yunhui Ge,Tongyi Dou,Thu Uyen Nguyen et al.
Yunhui Ge et al.
Adequate delivery of thyroid hormones to the brain is crucial for normal neurological development. MCT8 and OATP1C1, two solute carrier (SLC) transporters, mediate the passage of thyroid hormones across the blood-brain barrier and into the ...
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling [0.03%]
脑内皮细胞间隙连接偶联可使神经血管耦合时血管舒张迅速传播
Trevor Krolak,Luke Kaplan,Kathleen Navas et al.
Trevor Krolak et al.
To meet the brain's moment-to-moment energy demand, neural activation rapidly increases local blood flow. This process, known as neurovascular coupling, involves rapid, coordinated vasodilation of the brain's arterial network. Here, we demo...
Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals [0.03%]
成年行为哺乳动物多种神经元类群的高频电压动态影像学研究
Simon Haziza,Radosław Chrapkiewicz,Yanping Zhang et al.
Simon Haziza et al.
Fluorescent genetically encoded voltage indicators report transmembrane potentials of targeted cell types. However, voltage-imaging instrumentation has lacked the sensitivity to track spontaneous or evoked high-frequency voltage oscillation...