Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme [0.03%]
绕过进化死胡同并切换人类免疫治疗酶的限速步骤
John Blazeck,Christos S Karamitros,Kyle Ford et al.
John Blazeck et al.
The Trp metabolite kynurenine (KYN) accumulates in numerous solid tumours and mediates potent immunosuppression. Bacterial kynureninases (KYNases), which preferentially degrade kynurenine, can relieve immunosuppression in multiple cancer mo...
Evidence of substrate binding and product release via belt-sulfur mobilization of the nitrogenase cofactor [0.03%]
氮固定酶辅因子通过带状硫的移动来结合底物和释放产物的证据
Chi Chung Lee,Wonchull Kang,Andrew J Jasniewski et al.
Chi Chung Lee et al.
The Mo-nitrogenase catalyses the ambient reduction of N2 to NH3 at the M-cluster, a complex cofactor that comprises two metal-sulphur partial cubanes ligated by an interstitial carbide and three belt-sulphurs. A recent crystallographic stud...
Olefin Functionalization/Isomerization Enables Stereoselective Alkene Synthesis [0.03%]
烯烃的官能团化/异构化实现立体选择性合成 алкenes
Chen-Fei Liu,Hongyu Wang,Robert T Martin et al.
Chen-Fei Liu et al.
Despite tremendous efforts aimed at devising methods for stereoselective alkene synthesis, critical challenges are yet to be addressed. Direct access to a diverse range of 1aryl(boryl)-1-methyl-functionalized tri- and tetrasubstituted trans...
Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction [0.03%]
脱羧型烯醇化反应催化的非标准氨基酸生物合成反应
Jonathan M Ellis,Meghan E Campbell,Prasanth Kumar et al.
Jonathan M Ellis et al.
Enzymes are renowned for their catalytic efficiency and selectivity. Despite the wealth of carbon-carbon bond forming transformations in traditional organic chemistry and nature, relatively few C-C bond forming enzymes have found their way ...
Elucidation of radical- and oxygenate-driven paths in zeolite-catalysed conversion of methanol and methyl chloride to hydrocarbons [0.03%]
甲醇和氯化甲酯催化解析产生自由基和氧合物驱动途径的阐明
Alessia Cesarini,Sharon Mitchell,Guido Zichittella et al.
Alessia Cesarini et al.
Understanding hydrocarbon generation in the zeolite-catalysed conversions of methanol and methyl chloride requires advanced spectroscopic approaches to distinguish the complex mechanisms governing C-C bond formation, chain growth and the de...
Catalytic mechanism and endo-to- exo selectivity reversion of an octalin-forming natural Diels-Alderase [0.03%]
八氢苊形成型天然茋二烯酶的催化机制及其内-外选择性转换研究
Michio Sato,Shinji Kishimoto,Mamoru Yokoyama et al.
Michio Sato et al.
We have previously reported the identification of CghA, a proposed Diels-Alderase responsible for the formation of the bicyclic octalin core of the fungal secondary metabolite Sch210972. Here we show the crystal structure of the CghA-produc...
Deacylation-Aided C─H Alkylative Annulation through C─C Cleavage of Unstrained Ketones [0.03%]
通过C─C键断裂的未张紧酮类的脱酰基作用辅助的C─H烷基化环加成反应
Xukai Zhou,Yan Xu,Guangbin Dong
Xukai Zhou
Arene- and heteroarene-fused rings are pervasive in biologically active molecules. Direct annulation between a C─H bond on the aromatic core and a tethered alkyl moiety provides a straightforward approach to access these scaffolds; however...
Tzu-Hsien Shen,Liam Spillane,Jiayu Peng et al.
Tzu-Hsien Shen et al.
The surface wettability of catalysts is typically controlled via surface treatments that promote catalytic performance. Here we report on potential-regulated hydrophobicity/hydrophilicity at cobalt-based oxide interfaces with an alkaline so...
Gold-catalysed asymmetric net addition of unactivated propargylic C-H bonds to tethered aldehydes [0.03%]
金催化剂催化非活化炔丙C-H键与缚束醛的不对称加成反应
Ting Li,Xinpeng Cheng,Pengcheng Qian et al.
Ting Li et al.
The asymmetric one-step net addition of unactivated propargylic C-H bond to aldehyde leads to an atom-economic construction of versatile chiral propargylic alcohols but has not been realized previously. Here we show its implementation in an...
DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis [0.03%]
DYW结构域结构暗示植物器官ellerRNA编辑催化中的异常调控原则
Mizuki Takenaka,Sachi Takenaka,Tatjana Barthel et al.
Mizuki Takenaka et al.
RNA editosomes selectively deaminate cytidines to uridines in plant organellar transcripts-mostly to restore protein functionality and consequently facilitate mitochondrial and chloroplast function. The RNA editosomal pentatricopeptide repe...