Cascade CuH-Catalysed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products [0.03%]
铜催化炔烃反应合成光学活性1,1-二取代产物的研究
De-Wei Gao,Yang Gao,Huiling Shao et al.
De-Wei Gao et al.
Enantioenriched α-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks in organic synt...
Copper-catalysed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering [0.03%]
基于氧化还原缓冲的自由基接力活化铜催化醇与仲伯碳氢键交叉偶联反应
Huayou Hu,Si-Jie Chen,Mukunda Mandal et al.
Huayou Hu et al.
Cross-coupling reactions enable rapid, convergent synthesis of diverse molecules and provide the foundation for modern chemical synthesis. The most widely used methods employ sp2-hybridized coupling partners, such as aryl halides or related...
Nanostructuring unlocks high performance of platinum single-atom catalysts for stable vinyl chloride production [0.03%]
亚纳米结构解开了Pt单原子催化剂稳定氯乙烯生产的高性能解锁之谜
Selina K Kaiser,Edvin Fako,Gabriele Manzocchi et al.
Selina K Kaiser et al.
A worldwide replacement of the toxic mercuric chloride catalyst in vinyl chloride manufacture via acetylene hydrochlorination is slowed down by the limited durability of alternative catalytic systems at high space velocities. Here, we demon...
Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome [0.03%]
基于DNA折纸技术的合成凋亡小体诱导caspase-9激活
Bas J H M Rosier,Albert J Markvoort,Berta Gumí Audenis et al.
Bas J H M Rosier et al.
Living cells regulate key cellular processes by spatial organisation of catalytically active proteins in higher-order signalling complexes. These act as organising centres to facilitate proximity-induced activation and inhibition of multipl...
Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics [0.03%]
利用高压核磁共振研究酶催化反应的过渡态
John B Stiller,S Jordan Kerns,Marc Hoemberger et al.
John B Stiller et al.
Protein conformational changes are frequently essential for enzyme catalysis, and in several cases, shown to be the limiting factor for overall catalytic speed. However, a structural understanding of corresponding transition states, needed ...
Supported Catalyst Deactivation by Decomposition into Single Atoms Is Suppressed by Increasing Metal Loading [0.03%]
通过增加金属含量抑制催化剂分解为单原子从而抑制催化剂失活
Emmett D Goodman,Aaron C Johnston-Peck,Elisabeth M Dietze et al.
Emmett D Goodman et al.
In the high-temperature environments needed to perform catalytic processes, supported precious metal catalysts severely lose their activity over time. Even brief exposure to high temperatures can lead to significant losses in activity, whic...
Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis [0.03%]
揭示UDP-apiosphate生物合成中糖环收缩的酶促机制
Simone Savino,Annika J E Borg,Alexander Dennig et al.
Simone Savino et al.
D-Apiose is a C-branched pentose sugar important for plant cell wall development. Its biosynthesis as UDP-D-apiose involves decarboxylation of the UDP-D-glucuronic acid precursor coupled to pyranosyl-to-furanosyl sugar ring contraction. Thi...
Direct catalytic transformation of white phosphorus into arylphosphines and phosphonium salts [0.03%]
白磷直接催化转化为芳基膦和
Ulrich Lennert,Percia Beatrice Arockiam,Verena Streitferdt et al.
Ulrich Lennert et al.
Phosphorus compounds are ubiquitous in the chemical sciences, finding applications throughout industry and academia. Of particular interest to synthetic chemists are organophosphorus compounds, which contain P-C bonds. However, state-of-the...
Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure [0.03%]
由苯丙氨酸金属超分子淀粉样类结构组成的非蛋白质水解酶
Pandeeswar Makam,Sharma S R K C Yamijala,Kai Tao et al.
Pandeeswar Makam et al.
Enzymatic activity is crucial for various technological applications, yet the complex structures and limited stability of enzymes often hinder their use. Hence, de novo design of robust biocatalysts that are much simpler than their natural ...
Regiodivergent enantioselective C-H functionalization of Boc-1,3-oxazinanes and application to the synthesis of β2 and β3-amino acids [0.03%]
Boc-1,3-氧氮烷的区域和对映选择性C-H官能团化及在β2和β3氨基酸合成中的应用
Weilong Lin,Ke-Feng Zhang,Olivier Baudoin
Weilong Lin
β2- and β3-Amino acids are important chiral building blocks for the design of new pharmaceuticals and peptidomimetics. Here we report a straightforward regio- and enantiodivergent access to these compounds using a one-pot reaction compose...