A modular synthesis of azetidines from reactive triplet imine intermediates using an intermolecular aza Paternò-Büchi reaction [0.03%]
一个使用分子间aza Paternò-Büchi反应合成反应性三重态亚胺中间体的氮杂环丁烷模块化合成方法
Benedict A Williams,Michael J Tilby,Nicholas A Parker et al.
Benedict A Williams et al.
Azetidines are four-membered saturated N-heterocycles that are of interest in discovery chemistry. However, the implementation of these structures is limited by their synthetic intractability, resulting from their inherent ring strain. An a...
Enantioselective Pd-Catalysed Nucleophilic C(sp3)-H (Radio)fluorination [0.03%]
钯催化对映选择性亲核C(sp3)-H氟（放射）化反应
Nikita Chekshin,Luo-Yan Liu,D Quang Phan et al.
Nikita Chekshin et al.
Despite increasing demand for chiral fluorinated organic molecules, enantioselective C-H fluorination remains among the most challenging and sought-after transformations in organic synthesis. Furthermore, utilizing nucleophilic sources of f...
Zuodong Sun,Xin Zang,Qingyang Zhou et al.
Zuodong Sun et al.
Iminium-catalyzed cycloaddition is one of the most prominent examples of organocatalysis, yet a biological counterpart has not been reported despite the wide-spread occurrence of iminium adducts in enzymes. Here, we present biochemical, str...
Radical S-adenosyl-l-methionine FeS cluster implicated as the sulfur donor during albomycin biosynthesis [0.03%]
含硫辅因子的激进型S-腺苷蛋氨酸铁硫簇在白霉素生物合成中作为供硫底物的可能性
Richiro Ushimaru,Ziyang Zheng,Jin Xiong et al.
Richiro Ushimaru et al.
Carbon-sulfur bond-forming reactions in natural product biosynthesis largely involve Lewis acid/base chemistry with relatively few examples catalysed by radical S-adenosyl-l-methionine (SAM) enzymes. The latter have been limited to radical-...
Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics [0.03%]
机理和结构表征含铱细胞色素揭示动力学相关辅因子动态特性
Brandon J Bloomer,Sean N Natoli,Marc Garcia-Borràs et al.
Brandon J Bloomer et al.
Artificial metalloenzymes (ArMs), which contain non-native, typically synthetic, metal cofactors, are a flourishing class of biocatalyst for unnatural reactions. Although the number of these reactions is rapidly increasing, multi-faceted me...
Ligand binding to a Ni-Fe cluster orchestrates conformational changes of the CO-dehydrogenase-acetyl-CoA synthase complex [0.03%]
配体与一个Ni-Fe簇结合 调节CO脱氢酶-乙酰辅酶A合成酶复合物的构象变化
Jakob Ruickoldt,Julian Kreibich,Thomas Bick et al.
Jakob Ruickoldt et al.
Catalytic metal clusters play critical roles in important enzymatic pathways such as carbon fixation and energy conservation. However, how ligand binding to the active-site metal regulates conformational changes critical for enzyme function...
Accessing carbon, boron and germanium spiro stereocentres in a unified catalytic enantioselective approach [0.03%]
统一催化enantioselective方法中碳、硼和锗 Spiro 立体中心的访问
Yi-Xuan Cao,Anne-Sophie Chauvin,Shuo Tong et al.
Yi-Xuan Cao et al.
Achieving substrate generality in asymmetric catalysis remains a long-standing goal, particularly for the selective construction of chiral heteroatoms. Compared with carbon, sulfur, phosphorus and silicon stereogenic centres, methods for th...
Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(sp 2)-H functionalization [0.03%]
区域可控的钌催化C(sp2)—H活化在芳环上精准安装硅基合成手性基团
Jamie H Docherty,Mishra Deepak Hareram,Luke M Nichols et al.
Jamie H Docherty et al.
The site-selective functionalization of C(sp 2)-H bonds represents a powerful strategy for the synthesis of structurally diverse compounds with broad applicability. Here we report efficient regioselective catalytic methods for the formation...
Enantioconvergent nucleophilic substitution via synergistic phase-transfer catalysis [0.03%]
协同相转移催化实现不对称转化的亲核取代反应
Claire Dooley,Francesco Ibba,Bence B Botlik et al.
Claire Dooley et al.
Catalytic enantioconvergent nucleophilic substitution reactions of alkyl halides are highly valuable transformations, but they are notoriously difficult to implement. Specifically, nucleophilic fluorination is a renowned challenge, especial...
Ammonia synthesis via an engineered nitrogenase assembly pathway in Escherichia coli [0.03%]
工程化固氮酶途径在大肠杆菌中合成氨
Joseph B Solomon,Chi Chung Lee,Yiling A Liu et al.
Joseph B Solomon et al.
Heterologous expression of nitrogenase has been actively pursued because of the far-reaching impact of this enzyme on agriculture, energy and environment. Yet, isolation of an active two-component, metallocentre-containing nitrogenase from ...