Steppe productivity decline contributed to smallpox outbreak and the collapse of the last nomadic empire in the 1750s [0.03%]
18世纪50年代草原生产力下降导致天花流行及最后一个游牧帝国的崩溃
Wanru Tang,Keyan Fang,Hans W Linderholm et al.
Wanru Tang et al.
The collapse of the Dzungar Khanate in the 1750s marked the end of the world's last nomadic empire and reshaped Eurasian geopolitics. However, whether environmental and societal factors interplayed and contributed to its collapse remains un...
Qixuan Zhang,Lingyuan Lyu,Sneh Pancholi et al.
Qixuan Zhang et al.
Moiré superlattices in stacked two-dimensional crystals are powerful platforms for engineering correlated and topological quantum phases, with twisted graphene and transition metal dichalcogenides as prominent examples. Their angle-sensiti...
Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity [0.03%]
冷等离子体生物物理重编程免疫抑制性中性粒细胞可重新激活抗肿瘤免疫反应
Ganyu Wang,Zhiwei Cui,Xin Jiang et al.
Ganyu Wang et al.
Neutrophils are increasingly recognized as key orchestrators of the immunosuppressive tumor microenvironment, yet their intrinsic plasticity, short lifespan and resistance to genetic manipulation have impeded therapeutic targeting. Here, we...
Nucleic acid probe-functionalized self-powered sensor for detection of biomarkers in clinical urine samples [0.03%]
用于临床尿液样本生物标志物检测的核酸探针功能化自供电传感器
Qitao Zhou,Along Gao,Xiali Yang et al.
Qitao Zhou et al.
Triboelectric nanogenerator (TENG)-based self-powered biosensors can reduce ecological risks from energy storage device disposal and complex electronics manufacturing, offering cost-effective and eco-friendly diagnostic methods. However, in...
Vimentin remodeling in response to oxidants and electrophiles is modulated by pH [0.03%]
酸度调节氧化剂和亲电子剂引起的波形蛋白重塑
Alma E Martínez,Paula Martínez-Cenalmor,Patricia González-Jiménez et al.
Alma E Martínez et al.
Vimentin is critical for cell mechanosensing, cytoskeletal cross-talk, and stress responses and is finely tuned by posttranslational modifications. Vimentin single cysteine, C328, is a modification hotspot, essential for filament remodeling...
Alan M Rhoades,Joshua Snowball North,William Rudisill et al.
Alan M Rhoades et al.
Abrupt snowmelt, triggered by rain-on-snow events or "snow-eater heat waves," can cause flooding, initiate or accelerate snow drought, and affect water availability. However, the characteristics (e.g., area, duration, and frequency), impact...
Renoprotective effects of tubular glucagon receptor activation mediated by V-ATPase [0.03%]
由V-ATP酶介导的肾小管胰高血糖素受体激活的肾脏保护作用
Hua Qu,Mingyue Xu,Pan Du et al.
Hua Qu et al.
Recent clinical trials have shown that dual GLP-1R/GCGR agonists, including mazdutide and cotadutide, provide kidney benefits in patients with type 2 diabetes and CKD, suggesting a potential contribution of GCGR activation to these renal ef...
Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease [0.03%]
压力下的代谢适应失败导致Darier病的表皮细胞黏附缺陷
Robert M Harmon,Erin F McCarthy,Annette Krol et al.
Robert M Harmon et al.
Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (...
Global patterns and drivers of extinction risk in island endemic terrestrial vertebrates [0.03%]
孤立岛屿特有陆生脊椎动物受威胁模式及原因的全球分析
Yuyang Zhang,Jiang Wang,Yanxia Li et al.
Yuyang Zhang et al.
Island endemic terrestrial vertebrates, shaped by long-term isolation and ecological specialization, are particularly vulnerable to extinction pressure in the Anthropocene. However, cross-taxon extinction patterns and their drivers remain p...
Weijie Ji,Guiying He,Zhongyu Liu et al.
Weijie Ji et al.
Atomically precise metal nanoclusters (NCs) offer distinct platforms for exquisite control over photophysics, yet their complex photoluminescence (PL) mechanisms remain elusive. Here, we investigate a correlated series of Au24(SR)20 with th...