LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps [0.03%]
LIPT1丢失通过PrimPol介导的单链DNA间隙导致复制压力和PARP抑制剂敏感性
Zengfu Shang,Jui-Chung Chiang,Ching-Cheng Hsu et al.
Zengfu Shang et al.
Replication stress (RS) and altered metabolism are two hallmarks of cancer, yet how metabolic perturbations contribute to RS remains poorly understood. Lipotransferase 1 (LIPT1) catalyzes the covalent attachment of lipoic acid to mitochondr...
Cerium isotopes unveil hydrogenetic Fe-Mn encrustation occurring throughout from the oxygen minimum zone to the deep pacific [0.03%]
铈同位素揭示了氧气最低含量区域的铁锰壳层形成的机理并延伸至太平洋深处
Wenshuai Li,Ryoichi Nakada,Hajime Obata et al.
Wenshuai Li et al.
The interaction between a large, dissolved Mn reservoir in the oxygen minimum zone (OMZ) and the deeper oxygenated water allows for Mn oxidation and precipitation at their interface. The current paradigm posits that the OMZ acts as a Mn2+ s...
Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation [0.03%]
通过谱系特异性RAS激活驱动黑色素瘤肿瘤发生的剪接体突变
Ruixin Jiang,Peiqi Xing,Jindou Xie et al.
Ruixin Jiang et al.
Mutations in splicing factors are recurrent across human cancers and drive widespread RNA splicing dysregulation. Among these, SF3B1 is the most frequently mutated, yet its hotspot mutations exhibit lineage specificity, with SF3B1R625 mutat...
Piezoelectric neuromodulation of the subthalamic nucleus ameliorates motor and nonmotor symptoms of Parkinson's disease [0.03%]
用于帕金森病的皮电机调制改善运动和非运动症状
Di Zhao,Guangjun Zhong,Zhengyang Cao et al.
Di Zhao et al.
Traditional deep-brain stimulation via implanted electrodes can effectively treat neurological disorders, but surgical injury limits its clinical application. Here, we developed ultrasound-responsive piezoelectric nanoparticles for minimal-...
Håvard Hem Toftevaag,Bowei Dong,Nikolaos Farmakidis et al.
Håvard Hem Toftevaag et al.
Programmable photonic networks carry out universal unitary functions by independently operating on the amplitude and phase of guided light. Exploiting the reconfigurability and spatiospectral degrees of freedom of these systems, the majorit...
Augmenting ultrasound for continuous glucose monitoring via a wearable acoustically readable microneedle patch [0.03%]
用于连续葡萄糖监测的可穿戴声学读取微针贴片增强超声波技术
Wanglinhan Zhang,Jiangang Xu,Xinjia Li et al.
Wanglinhan Zhang et al.
Continuous glucose monitoring (CGM) represents substantial advancement, yet poses a challenge in wearable health care development. Current enzymatic CGM faces limitations in stability, cost, and durability. We introduce an enzyme-free, wear...
Joanne Si Ying Tan,Zhuoyue Li,Sixing Xiong et al.
Joanne Si Ying Tan et al.
The Internet of Things (IoT) era witnessed a surge in wearable devices for the human body, each requiring a power source that supports long-term operation. However, batteries are depletable and require replacement, while the effectiveness o...
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine [0.03%]
NMDAR-GABAA受体相互作用介导的氯胺酮次级代谢产物脱氢亚甲基二氧苯异丙胺的快速抗抑郁机制
Anisul Arefin,Jihye Kim,Manas Pratim Chakraborty et al.
Anisul Arefin et al.
A complex ensemble of neuromodulatory receptors orchestrates the many forms of synaptic plasticity that drive behavioral state changes, but an understanding of how such receptors functionally interact is limited. Here, we find that the anti...
Ultra-narrowband perovskite single-crystal photodetector enabled by dynamic space charge region for portable concentration detection [0.03%]
基于动态空间电荷区域的超窄带钙钛矿单晶光电探测器用于便携式检测传感
Gangjian Hu,Hongyu Bian,Ding Luo et al.
Gangjian Hu et al.
Narrowband photodetectors with wavelength-selective light response are essential for applications involving environmental monitoring and biomedical sensing. Although perovskites with excellent optoelectronic characteristics and tunable band...
An AI-driven, wearable, conformal ring system for real-time and user-independent sign language interpretation [0.03%]
一种基于人工智能的可穿戴式变形戒指系统 实现实时且独立于用户的 sign 语言翻译
Jaejin Park,Yejee Shin,In Sik Min et al.
Jaejin Park et al.
Sign language translation systems have long aimed to bridge the communication between signers and nonsigners. However, preliminary systems rely on glove-type wearables or wired sensor arrays, which constrain hand movement, reduce comfort, a...