Heterochronic parabiosis uncovers AdipoR1 as a critical player in retinal rejuvenation [0.03%]
异龄体共生研究发现AdipoR1在视网膜年轻化中的关键作用
Yidan Liu,Xiuxing Liu,Jianjie Lv et al.
Yidan Liu et al.
Aging induces substantial structural and functional decline in the retina, yet the molecular drivers of this process remain elusive. In this study, we used heterochronic parabiosis (HP) combined with single-cell RNA sequencing to generate c...
Atopy-related immune profiles are subject to genetic influence as evaluated using school-aged twin pairs [0.03%]
利用学龄期双胞胎评价与过敏相关的免疫特征受遗传因素影响
Jonatan Leffler,James F Read,Danny Mok et al.
Jonatan Leffler et al.
The interaction of genetic and environmental contributions to immunological traits and their association with atopic disease remain unclear. Flow cytometry and in vitro cytokine responses were used to characterize immune profiles from 93 sc...
Understanding silicone elastomer curing and adhesion for stronger soft devices [0.03%]
详解硅胶固化及黏附作用 以实现更强软体机器人
Te Faye Yap,Jasmine Klinkao,Sofia Urbina et al.
Te Faye Yap et al.
Silicone elastomers are widely used in biomedical devices and soft machines because of their compliance, inertness, and biocompatibility. Their sol-gel transition during curing enables mold casting and layer-by-layer manufacturing, allowing...
Multicellular muscle-tendon bioprinting of mechanically optimized musculoskeletal bioactuators with enhanced force transmission [0.03%]
机械性能优化的生物肌肉激发器的多细胞肌腱生物打印技术以增强力量传导
Miriam Filippi,Diana Mock,Judith Fuentes et al.
Miriam Filippi et al.
Biohybrid actuators leveraging living muscle tissue offer the potential to replicate natural motion for biomedical and robotic applications. However, challenges such as limited force output and inefficient force transfer at tissue interface...
Noninvasive real-time monitoring of cellular spatiotemporal dynamics via machine learning-enhanced electrical impedance spectroscopy [0.03%]
基于机器学习增强型电阻抗谱学的细胞时空动力学非侵入式实时监测
Manuel Carrasco Yagüe,Xingjian Zhang,Matthew Volpatti et al.
Manuel Carrasco Yagüe et al.
Monitoring cellular spatiotemporal dynamics is essential for understanding complex biological processes such as organ development and cancer progression. Using live-cell fluorescence microscopy to track cellular dynamics is often limited by...
Childhood skeletal lesions common in prehistory are present in living forager-farmers and predict adult markers of immune function [0.03%]
当代狩猎采集者和农民中的童年骨骼损伤具有普遍性，并可预测成年免疫功能标志物
Amy S Anderson,Aaron Blackwell,M Linda Sutherland et al.
Amy S Anderson et al.
Porous cranial lesions (cribra cranii and cribra orbitalia) are widely used by archaeologists as skeletal markers of poor child health. However, their use has not been validated with systematic data from contemporary populations, where ther...
Tetanus-driven biohybrid multijoint robots powered by muscle rings with enhanced contractile force [0.03%]
破伤风驱动的肌肉环复合多自由度机器人
Tomohiro Morita,Minghao Nie,Shoji Takeuchi
Tomohiro Morita
Biohybrid actuators using muscle rings have been limited to twitching movements and are unsuitable for sustained contractile force applications. In this study, we developed muscle rings capable of generating high contractile forces under te...
Robot metabolism: Toward machines that can grow by consuming other machines [0.03%]
机器的新陈代谢：可以靠“吃”其他机器来生长的设备
Philippe Martin Wyder,Riyaan Bakhda,Meiqi Zhao et al.
Philippe Martin Wyder et al.
Biological lifeforms can heal, grow, adapt, and reproduce, which are abilities essential for sustained survival and development. In contrast, robots today are primarily monolithic machines with limited ability to self-repair, physically dev...
William Cartwright Drennan,Onur Aydin,Bashar Emon et al.
William Cartwright Drennan et al.
The field of biohybrid robotics focuses on using biological actuators to study the emergent properties of tissues and the locomotion of living organisms. On the basis of models of swimming at small size scales, we designed and fabricated a ...
Binary host-guest strategy enables bright and efficient lead-free zero-dimensional tin halide light-emitting diodes [0.03%]
二元宿主-客体策略实现高效明亮的无铅零维锡卤化物发光二极管
Qian Teng,Qinghua Tan,Mengyue Hou et al.
Qian Teng et al.
Lead-free tin perovskites present remarkable environmental advantages over lead-based counterparts. While substantial progress has been made with three-dimensional (3D) and 2D tin perovskite LEDs (PeLEDs), the potential of 0D tin perovskite...