Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus [0.03%]
关于包膜古菌病毒纺锤形结构及其感染策略的见解
Haonan Zhang,Haina Wang,Yan Li et al.
Haonan Zhang et al.
Archaeal viruses are well known for their diverse morphologies and extreme stability. Here, we used cryo-electron tomography to analyze the structure of Sulfolobus ellipsoid virus 1 (SEV1), an archaeal virus with an ellipsoidal shape and a ...
Xiao Wu,Jianxi Zhu,Hongmei Yang et al.
Xiao Wu et al.
In the deep biosphere, where surface-derived substrates are depleted, microbial communities rely on redox pairs generated through water-rock reactions to sustain metabolism. A notable example of this is the production of hydrogen gas (H2) a...
Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine [0.03%]
利用组织衍生的富含线粒体的细胞外囊泡促进线粒体生物发生以用于再生医学
Peng Lou,Xiyue Zhou,Yimeng Zhang et al.
Peng Lou et al.
Mitochondrial damage is a critical pathological factor in various forms of tissue injury, and specific therapies with high biosafety are desirable. Inspired by the natural role of extracellular vesicles (EVs) in regulating mitochondrial met...
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress [0.03%]
NRBP1 假激酶通过结合并激活渗透压应激反应的 WNK 通路发挥功能
Ramchandra V Amnekar,Toby Dite,Pawel Lis et al.
Ramchandra V Amnekar et al.
WNK family kinases are regulated by osmotic stress and control ion homeostasis by activating SPAK and OXSR1 kinases. Using a proximity labeling approach, we found that osmotic stress promotes the association of WNK1 with the NRBP1 pseudokin...
Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies [0.03%]
飞虱效应因子通过将防御蛋白募集到加工体抑制植物免疫反应
Qun Liu,Anna C M Neefjes,Archana Singh et al.
Qun Liu et al.
Aphids are small insects that have developed specialized mouthparts and effector proteins to establish long-term relationships with plants. The peach-potato aphid Myzus persicae is a generalist, feeding on many plant species and capable of ...
Polytelluoxane as the ideal formulation for EUV photoresist [0.03%]
新型超强酸聚 tellurium 氧化物树脂有望成为极紫外光刻技术的关键材料
Ruihao Zhou,Muqing Cao,Yizheng Tan et al.
Ruihao Zhou et al.
Extreme ultraviolet (EUV) lithography has become the essence of advanced semiconductor manufacturing processes. While enabling smaller feature sizes, EUV lithography imposes increasingly stringent requirements on the comprehensive performan...
Size matters: Micro- versus nanobubbles in ultrasound imaging and therapy [0.03%]
大小有影响：微气泡与纳米气泡在超声成像和治疗中的作用
Mihir Sheth,Caed Knight,Qiang Wu et al.
Mihir Sheth et al.
This study investigates the reported ability of nanobubbles (1 micrometer in diameter). Eight hypotheses were examined. Both the theoretical and experimental results supported only one hypothesis: The apparent echogenicity of nanobubbles un...
Stability and decay of subradiant patterns in a quantum gas with photon-mediated interactions [0.03%]
量子气体中通过光介导相互作用的亚辐射模式的稳定性和衰减
Alexander Baumgärtner,Simon Hertlein,Tom Schmit et al.
Alexander Baumgärtner et al.
Metastability and its relaxation mechanisms challenge our understanding of the stability of quantum many-body systems, revealing a gap between the microscopic dynamics of the individual components and the effective descriptions used for mac...
Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors [0.03%]
MYC抑制剂诱导的代谢障碍是癌症的关键弱点
William Yang,Qianyu Guo,Songhua Quan et al.
William Yang et al.
MYC is a key driver in many aggressive and therapy-resistant cancers. We have developed and characterized a small-molecule MYC inhibitor named MYCi975. To uncover combination strategies for MYC inhibitors, we conducted a genome-wide CRISPR ...
Lattice structure musculoskeletal robots: Harnessing programmable geometric topology and anisotropy [0.03%]
具备可编程几何拓扑和各向异性的晶格结构肌骨机器人
Qinghua Guan,Benhui Dai,Hung Hon Cheng et al.
Qinghua Guan et al.
Natural musculoskeletal systems combine soft tissues and rigid structures to achieve diverse mechanical behaviors that are both adaptive and precise. Inspired by these systems, we propose a programming method for designing bioinspired soft-...