Highly Enantioselective Construction of Oxazolidinone Rings via Enzymatic C(sp3)-H Amination [0.03%]
手性酶促C(sp3)–H氨化构建 oxazolidinone 类化合物
Jadab Majhi,Satyajit Roy,Anwita Chattopadhyay et al.
Jadab Majhi et al.
Oxazolidinones are important heterocycles widely utilized in medicinal chemistry for the synthesis of antifungals, antibacterials, and other bioactive compounds and in organic chemistry as chiral auxiliaries for asymmetric synthesis. Herein...
Vincent R Viviani,Travis L Buchanan,An Thien Ho et al.
Vincent R Viviani et al.
The carboamination of 1,3-dienes provides direct and efficient access to allylic amines in a step-economical fashion. Herein, we disclose a three-component 1,3-diene carboamination reaction that provides modular access to a multitude of all...
Transmetallation by Halogen-Cyanide Metathesis in Water: Application to Cyanide Ion-Free Palladium Catalyzed Cyanation [0.03%]
水溶液中通过卤化氰交换的金属交换应用于自由氰基的钯催化氰化反应
Ashish Dusunge,Ramesh Hiralal Choudhary,Jacek B Jasinski et al.
Ashish Dusunge et al.
Aryl nitriles are important synthons in organic chemistry, yet conventional cyanation methods mostly generate free cyanide ions, creating acute safety hazards and wastewater contamination issues. We report a Pd-catalyzed cyanide ion-free cy...
Electrochemical Oxygen-Atom Transfer to Alkenes and Pyridines with a Mn-Porphyrin Catalyst Using Water as the Source of Oxygen [0.03%]
用水作为氧源的锰卟啉催化剂电化学体系下的烯烃和吡啶的氧原子转移反应
Suha Yacoob,Md Asmaul Hoque,Tianxiao Jiang et al.
Suha Yacoob et al.
Oxygen-atom transfer (OAT) reactions, such as epoxidation, often use stoichiometric high-energy oxygen donors that present safety hazards, especially on large scale. Electrochemistry provides a means to replace these reagents with water as ...
Systematic Modeling of Covalent Inhibitors of SARS-CoV-2 Main Protease and Its Mutants [0.03%]
SARS-CoV-2主要蛋白酶及其突变体共价抑制剂的系统建模
Pan-Pan Chen,Ashim Nandi,Arieh Warshel
Pan-Pan Chen
The SARS-CoV-2 main protease (Mpro) is a key antiviral target due to its essential role in viral replication and the absence of close human homologues. Covalent inhibitors, which form durable bonds with critical active-site residues have sh...
Enantioselective Carbonyl Crotylation of Alcohol Proelectrophiles via Ruthenium-Catalyzed Hydrogen Autotransfer: Innovation Inspired by Polyketide Total Synthesis [0.03%]
手性醇促电子体的不对称羰基crotylation：基于聚酮类天然产物全合成的钌催化氢自动转移反应的创新
Peyton W Meares,Catherine G Santana,Michael J Krische
Peyton W Meares
From the first report of 1,3-butadiene-mediated carbonyl crotylation in 2008 to the recent development of a simple ruthenium-JOSIPHOS catalyst derived from inexpensive, air-stable RuHCl(CO)(PPh3)3, the discovery and evolution of 1,3-butadie...
Reactive Trapping of Dilute Methane Emissions by Surface Oxygen Intermediates on Copper Zeolites for Total Oxidation to CO2 [0.03%]
铜丝光沸石上表面氧中间体吸附稀释甲烷使其完全氧化生成二氧化碳
Jing Ma,Dieter Plessers,Laura D Elmendorf et al.
Jing Ma et al.
Through reactive trapping, Cu-zeolites are shown to catalytically remove methane at 2 ppm, oxidizing it to CO2 in air at 350 °C. Partial reaction orders are 0.56-0.75 in CH4 and quasi-zero in O2. Together with kinetic analysis of reaction ...
Rakesh K Roy,Dimitri Antoniou,Steven D Schwartz
Rakesh K Roy
Behind the catalytic efficiency of enzymes lies a finely tuned dynamic interplay among residues that cooperatively orchestrate the reaction. Steroid 5α-reductase type 2 (SRD5A2) catalyzes NADPH-dependent reduction of testosterone to dihydr...
Fe(III)/Pyridine N-oxide LMCT Photocatalysis for Unactivated C(sp3)-H Functionalizations [0.03%]
未活化C(sp3)–H官能团化的Fe(III)/吡啶N氧化物LMCT光催化作用
Jun Luo,Deepak Ranjan Pradhan,Jujhar Singh et al.
Jun Luo et al.
Heteroatom-centered radical-mediated hydrogenatom transfer (HAT) has emerged as a powerful tool for C-H functionalization, yet selective activation of unactivated C(sp3)-H bonds, especially at the primary sites, remains a significant challe...
Million-Fold Activation of C-H Bonds by Fluorinated Nonheme FeIV=O Complexes via Second Sphere Equatorial Substitution and Catalytic Epoxidation to Boot [0.03%]
经由第二配位球赤道取代激活氟化非血红素FeIV=O配合物中的C-H键使其增强一百万倍以及实现催化环氧化反应
Bittu Chandra,Chupeng Li,Mursaleem Ansari et al.
Bittu Chandra et al.
FeIV=O units found in the active sites of nonheme iron oxygenases and related synthetic analogs are intriguing intermediates capable of performing challenging oxygenation reactions. The first crystal structure of such a crucial species in a...