Enantioselective Carbonyl Crotylation of Alcohol Proelectrophiles via Ruthenium-Catalyzed Hydrogen Autotransfer: Innovation Inspired by Polyketide Total Synthesis
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From the first report of 1,3-butadiene-mediated carbonyl crotylation in 2008 to the recent development of a simple ruthenium-JOSIPHOS catalyst derived from inexpensive, air-stable RuHCl(CO)(PPh3)3, the discovery and evolution of 1,3-butadiene-mediated carbonyl... ...
