Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment [0.03%]
单细胞转录组分析揭示肠道微生物群通过调节肿瘤微环境增强免疫治疗效力
Minyuan Cao,Yun Deng,Qing Hao et al.
Minyuan Cao et al.
The gut microbiota crucially regulates the efficacy of immune checkpoint inhibitor (ICI) based immunotherapy, but the underlying mechanisms remain unclear at the single-cell resolution. Using single-cell RNA sequencing and subsequent valida...
Branched-chain amino acids alleviate sepsis-induced myocardial dysfunction via inhibition of protein tyrosine phosphatase-6 [0.03%]
支链氨基酸通过抑制蛋白酪氨酸磷酸酶-6改善脓毒症诱导的心肌功能障碍
Shu-Rui Pang,Yu-Tong Zhu,Hou-Zao Chen et al.
Shu-Rui Pang et al.
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival [0.03%]
脂溶性聚(β-氨基酯)miR-590-3p纳米微RNA多管齐下抑制SMAD通路并抑制间充质型胶质母细胞瘤的生长和延长生存期
Jack Korleski,Sophie Sall,Kathryn M Luly et al.
Jack Korleski et al.
Despite aggressive therapy, glioblastoma (GBM) recurs in almost all patients and treatment options are very limited. Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remain in our ab...
Huanzhao Peng,Minyang Fu,Jiong Li
Huanzhao Peng
You are what you eat: metabolic recycling of phagocytosed bacteria modulates macrophage immunity [0.03%]
吃啥补啥：巨噬细胞通过代谢途径回收胞吞细菌的营养物质从而调节自身免疫功能
Syamantak Basu,Manuela Rossol
Syamantak Basu
Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer [0.03%]
结直肠癌中线粒体源性乙酰辅酶A乙酰转移酶1通过调节自然杀伤细胞的抗肿瘤免疫作用促进癌症发展
Chen Wei,Kun Liao,Hao-Jie Chen et al.
Chen Wei et al.
Tumor metabolism often interferes with the immune microenvironment. Although natural killer (NK) cells play pivotal roles in antitumor immunity, the connection between NK cells and tumor metabolism remains unclear. Our systematic analysis o...
N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan [0.03%]
N-去糖基化靶向嵌合体(DGlyTAC)：通过特异性去除N-聚糖失活免疫检查点蛋白的新策略
Li Li,Jiajia Wu,Weiqian Cao et al.
Li Li et al.
Among the leading methods for triggering therapeutic anti-cancer immunity is the inhibition of immune checkpoint pathways. N-glycosylation is found to be essential for the function of various immune checkpoint proteins, playing a critical r...
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury [0.03%]
A20通过抑制氧化的自身DNA介导的炎症在急性肾损伤中的作用研究
Hanwen Li,Yongyao Wu,Lisha Xiang et al.
Hanwen Li et al.
The ubiquitin-editing enzyme A20 is known to regulate inflammation and maintain homeostasis, but its role in self-DNA-mediated inflammation in acute kidney injury (AKI) is not well understood. Here, our study demonstrated that oxidized self...
Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy [0.03%]
结合超声波的仿生纳米药物用于癌症治疗
Juan Guo,Xueting Pan,Qingyuan Wu et al.
Juan Guo et al.
Addressing the critical biological barriers of targeted accumulation and deep tumor penetration remains essential for the clinical translation of nanomedicines. However, existing nanomedicines often face challenges during in vivo transporta...
Yang Yang,Bing Zhao,Yuanzhe Wang et al.
Yang Yang et al.
Diabetic neuropathy (DN) is a prevalent and debilitating complication of diabetes mellitus, significantly impacting patient quality of life and contributing to morbidity and mortality. Affecting approximately 50% of patients with diabetes, ...