The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects [0.03%]
体内CAR-T治疗药物的发展：挑战与监管展望
Jiaqi Lu,Jing Cui,Jing Dong et al.
Jiaqi Lu et al.
Chimeric antigen receptor T-cell (CAR-T) therapy, a groundbreaking advancement in cancer immunotherapy, has demonstrated remarkable efficacy in treating hematological malignancies and autoimmune diseases. However, conventional ex vivo CAR-T...
DNA origami-based virus-like particles: a new class of HIV vaccine candidates with superior immunogenic properties [0.03%]
基于DNA折纸技术的病毒样颗粒：一类具有优越免疫原性的HIV疫苗候选产品
Frauke Muecksch,Juan Hamdan,Oliver T Fackler
Frauke Muecksch
Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial [0.03%]
氟维司群与卡培他滨用作激素受体阳性、HER2阴性乳腺癌一线化疗后的维持治疗： FAMILY多中心、开放标签、随机III期试验
Wenjing Wu,Yaping Yang,Haizhu Chen et al.
Wenjing Wu et al.
Maintenance therapy is key in prolonging remission and improving quality of life for hormone receptor-positive (HR + ), HER-2 negative (HER2-) metastatic breast cancer (MBC), but optimal strategies remain debated. This multicenter, open-lab...
Lactate metabolism and lactylation in cancer: from pathogenesis to therapeutic advances [0.03%]
乳酸代谢与乳酰化在癌症中的作用：从发病机制到治疗进展
Chunyao Fang,Suiqing Zhou,Kai Yu et al.
Chunyao Fang et al.
Lactate and its mediated modification, lactylation, are receiving increasing attention in the field of tumor biology. This review provides a comprehensive overview of the mechanistic involvement of lactate and lactylation in key oncogenic p...
Targeting ZMIZ1 induces differentiation in acute myeloid leukemia via chromatin remodeling [0.03%]
靶向ZMIZ1通过表观遗传重编程可诱发急性髓系白血病细胞分化成熟
Huimin Li,Yabin Liu,Jiachen Cui et al.
Huimin Li et al.
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by profound transcriptional dysregulation and impaired hematopoietic differentiation. While differentiation therapy has revolutionized treatment in acute pro...
GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors [0.03%]
GSK-3调节CD4-CD8合作以产生超级武装的CD8+细胞毒性T淋巴细胞对抗肿瘤免疫疗法
Bastien Moës,Janna Krueger,Chen Liu et al.
Bastien Moës et al.
Although the efficacy of immune checkpoint blockade (ICB) depends on coordinated activity across progenitor and terminal effector CD4⁺ and CD8⁺ T-cell compartments, the cell-intrinsic pathways that enable this cooperation remain incomplet...
Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD [0.03%]
髓系Mas通过驱动Spi1的丙酮酸激酶M2介导的白喉拉克酰化来为MASLD中的炎症衰老供能
Luying Zhao,Shujing Xu,Shikai Qiao et al.
Luying Zhao et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by unresolved inflammation, yet precise mechanisms linking immune metabolism to disease progression remain elusive. Here, we identified myeloid-expressed Mas, a G pr...
VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes [0.03%]
去泛素化AMPKγ1并阻止心脏肌细胞中AMPKα-γ亚基组装的VCPIP1驱动糖尿病心肌病
Xue Han,Zhuqi Huang,Guoxuan Liu et al.
Xue Han et al.
Protein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined. This study sought to delineate...
Targeting EHMT2 overcomes 5-fluorouracil resistance in colorectal cancer by modulating cell cycle and apoptosis [0.03%]
靶向EHMT2通过调节细胞周期和凋亡克服结直肠癌对氟尿嘧啶的耐药性
In Hwan Tae,Yunsang Kang,Jinkwon Lee et al.
In Hwan Tae et al.
5-Fluorouracil (5-FU) is a first-line chemotherapy commonly used to treat colorectal cancer (CRC). However, the development of acquired resistance to 5-FU remains a significant clinical challenge, and the underlying epigenetic mechanisms ar...