Yufei Wu,Xiang Li,Hanzhe Liu et al.
Yufei Wu et al.
The oral and maxillofacial region comprises a variety of organs made up of multiple soft and hard tissue, which are anatomically vulnerable to the pathogenic factors of trauma, inflammation, and cancer. The studies of this intricate entity ...
Ana Beatriz G de Carvalho,Maedeh Rahimnejad,Rodrigo L M S Oliveira et al.
Ana Beatriz G de Carvalho et al.
The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxil...
An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation [0.03%]
神经突生长抑制因子A在牙釉质形成中的意外作用
Pierfrancesco Pagella,Chai Foong Lai,Laurence Pirenne et al.
Pierfrancesco Pagella et al.
Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical trials aiming at promoting the regeneration of the central nervous system upon traumatic and ischemic injury. In this...
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches [0.03%]
牙周炎对血栓性疾病的影响：从临床角度到未来治疗策略
Jinting Ge,Xuanzhi Zhu,Chengxin Weng et al.
Jinting Ge et al.
Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance. Uncontrolled periodontal infections are the leading cause of tooth loss in adults. Thrombotic diseases can lead to pa...
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B [0.03%]
CREB3L1缺乏通过TMEM30B部分抑制成牙本质细胞分化及磨牙牙本质沉积
Yuanyuan Li,Yuxiu Lin,Jinqiang Guo et al.
Yuanyuan Li et al.
Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for dentinogenesis. Our previous single-cell profile and RNAscope for odontoblast lineage revealed that cyclic adenosine ...
Ruijie Huang,Chenchen Zhou,Ling Zhan et al.
Ruijie Huang et al.
Traumatic dental injuries (TDIs) of teeth occur frequently in children and adolescents. TDIs that impact the periodontal tissues and alveolar tissue can be classified into concussion, subluxation, extrusive luxation, intrusive luxation, lat...
Ke Wu,Xiaochan Li,Yunyang Bai et al.
Ke Wu et al.
Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of physiological processes. The circadian clock mechanisms in brain and peripheral tissues can oscillate independently o...
Bin Chen,Yanan Zhu,Minkui Lin et al.
Bin Chen et al.
Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms, including unique anatomical and microbiological characteristics and multiple contributing factors. This...
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis [0.03%]
全身感染牙龈卟啉单胞菌可激活巨噬细胞中的caspase-11介导的炎性小体，从而加重关节炎症状
Tokuju Okano,Hiroshi Ashida,Noriko Komatsu et al.
Tokuju Okano et al.
Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis (RA). However, the mechanism is poo...
Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out [0.03%]
成人正畸治疗中的年龄相关牙槽骨适应不良问题及新对策
Yunfan Zhang,Jiale Yan,Yuning Zhang et al.
Yunfan Zhang et al.
Compared with teenage patients, adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodontic treatment, indicating the maladaptation of alveolar bone homeostasis under orthodontic f...