Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation [0.03%]
Ran Tao,Sufang Liu,Joshua Crawford et al.
Ran Tao et al.
Pain is the most common symptom of temporomandibular joint (TMJ) disorders, which present significant clinical challenges due to their complexity and limited treatment options. Our previous study demonstrates that gut microbiome-derived but...
Rui Sun,Yifan Xu,Yang Wu et al.
Rui Sun et al.
The third molar is the most developmentally delayed of the permanent teeth and has the highest incidence of pericoronitis and odontogenic space infections. Impacted third molars significantly increase the risk of periodontitis, dental carie...
SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway [0.03%]
SLIT3通过Akt/GSK3β/β-catenin信号通路调控牙诱导分化的新机制
Lingyu Jiang,Liu Liu,Fan Yang et al.
Lingyu Jiang et al.
The odontogenic differentiation of Stem Cells from Apical Papilla (SCAP) are governed by various extracellular matrix proteins, playing a crucial role in dentin formation and regeneration. Extracellular matrix protein SLIT3, a classical axo...
The structure and function of taste G protein-coupled receptors and their implications in diseases [0.03%]
味觉G蛋白偶联受体的结构与功能及其对疾病的影响
Ruohan Zhai,Xihao Yong,Peihua Jiang et al.
Ruohan Zhai et al.
Taste G protein-coupled receptors (GPCRs), including sweet (TAS1Rs) and bitter (TAS2Rs) taste receptors, are essential for detecting nutrients and avoiding toxins, influencing dietary behavior, metabolism, and overall health. Beyond their r...
OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development [0.03%]
OGT介导MEIS2的O-连接糖基化修饰影响腭成骨发育
Zhongyin Zhang,Zerui Shan,Xinyu Chen et al.
Zhongyin Zhang et al.
Post-translational modifications (PTMs) have been gradually elucidated in congenital malformations such as cleft palate. Among them, O-GlcNAcylation as a dynamic PTM of proteins regulates various critical biological processes including tran...
Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study [0.03%]
牙周炎与早期慢性肾脏病患者肾功能降低和尿蛋白之间的关联：一项基于人口的调查研究
Christian Schmidt-Lauber,Merle Ebinghaus,Katrin Borof et al.
Christian Schmidt-Lauber et al.
Periodontitis has been linked to chronic kidney disease (CKD) through systemic inflammation. However, evidence in early CKD remains limited. We analyzed 6 179 participants from a population-based cohort (median age 62 years; 51% women). Per...
Hanqi Fu,Peng Chen,Zuping Wu et al.
Hanqi Fu et al.
Dental tissues development involves two distinct cell lineages: mesenchymal cells (derived from the cranial neural crest) and epithelial cells (derived from oral ectoderm and pharyngeal epithelium). Emerging evidence highlights the remarkab...
Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients [0.03%]
成人正畸结缔组织增量术专家共识
Runzhi Guo,Xiaotong Li,Jianxia Hou et al.
Runzhi Guo et al.
Alveolar bone defects, including dehiscence and fenestration, are commonly encountered in adult patients seeking orthodontic treatment. These anatomical deficiencies increase the risk of periodontal complications and may significantly compr...
Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models [0.03%]
基于机械应力和关节盘脱位模型定义颞下颌关节骨关节炎起始阶段的滑膜细胞器反应
Kazuhiro Shibusaka,Soichiro Negishi,Asuka Terashima et al.
Kazuhiro Shibusaka et al.
Temporomandibular joint osteoarthritis (TMJ-OA), the most common degenerative disease of the TMJ, is influenced by various adaptive, inflammatory, and mechanical stressors. In this study, we describe molecular alterations of the synovium of...
Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis [0.03%]
HH-TGF-β信号通路在牙根发育中的协同作用及其分子机制研究
Tao Zhou,Linyang Huang,Yaxin Xie et al.
Tao Zhou et al.
Hedgehog (HH) signaling is essential in directing the fate determination of postmigratory cranial neural crest cells (CNCCs) to ensure proper craniofacial development. Gli transcription factors (TFs) are established as primary effectors of ...