Fuel to fire: developmental niche-empowered ApoEVs unlock adult hierarchical tissue regenerative potential via mitochondrial complex I-driven developmental metabolic profile [0.03%]
Yanshu Zhang,Jieyun Xu,Yuhan Shi et al.
Yanshu Zhang et al.
Organ defects involving hierarchical tissue structures remain a major challenge due to limited regenerative capacity in adulthood. To break this bottleneck, regenerative medicine is undergoing a paradigm shift from simulating the healing pr...
Weiqi Li,Yinghui Wen,Zhenyuan Huang et al.
Weiqi Li et al.
Supramolecular hydrogels hold significant potential in drug delivery and tissue engineering, with standing out for their unique properties. Despite their promise, predicting nucleoside bioactivity remains challenging. This study aims to pre...
DNA framework-based nanomedicine platform: a triple-function strategy for treating periodontitis via antibacterial, anti-inflammatory, and osteogenesis-promoting activities [0.03%]
一种基于DNA框架的纳米医药平台：通过抗菌、抗炎和促骨发生作用治疗牙周病的三重功能策略
Geru Zhang,Weitong Cui,Haoyan Wu et al.
Geru Zhang et al.
Periodontitis is the most prevalent chronic inflammatory condition affecting oral health and is associated with long treatment duration. It is triggered by microbial plaque, which leads to localized and diffuse inflammation, ultimately caus...
Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns [0.03%]
基于突变特征的分类揭示了具有不同分子模式的新兴口腔癌亚型
Sophie Deneuve,Béatrice Fervers,Julia S Bruno et al.
Sophie Deneuve et al.
Tobacco use, alcohol consumption, and infection with human papilloma virus (HPV) are well-established risk factors for head and neck squamous cell carcinomas (HNSCC). However, the incidence of oral cancer, particularly in the mobile tongue,...
Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation [0.03%]
单细胞多组学测序揭示了肠道菌群代谢产物丁酸介导痛觉调制的细胞特异性转录和染色质可及性图谱
Ran Tao,Sufang Liu,Joshua Crawford et al.
Ran Tao et al.
Pain is the most common symptom of temporomandibular joint (TMJ) disorders, which present significant clinical challenges due to their complexity and limited treatment options. Our previous study demonstrates that gut microbiome-derived but...
Rui Sun,Yifan Xu,Yang Wu et al.
Rui Sun et al.
The third molar is the most developmentally delayed of the permanent teeth and has the highest incidence of pericoronitis and odontogenic space infections. Impacted third molars significantly increase the risk of periodontitis, dental carie...
SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway [0.03%]
SLIT3通过Akt/GSK3β/β-catenin信号通路调控牙诱导分化的新机制
Lingyu Jiang,Liu Liu,Fan Yang et al.
Lingyu Jiang et al.
The odontogenic differentiation of Stem Cells from Apical Papilla (SCAP) are governed by various extracellular matrix proteins, playing a crucial role in dentin formation and regeneration. Extracellular matrix protein SLIT3, a classical axo...
The structure and function of taste G protein-coupled receptors and their implications in diseases [0.03%]
味觉G蛋白偶联受体的结构与功能及其对疾病的影响
Ruohan Zhai,Xihao Yong,Peihua Jiang et al.
Ruohan Zhai et al.
Taste G protein-coupled receptors (GPCRs), including sweet (TAS1Rs) and bitter (TAS2Rs) taste receptors, are essential for detecting nutrients and avoiding toxins, influencing dietary behavior, metabolism, and overall health. Beyond their r...
OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development [0.03%]
OGT介导MEIS2的O-连接糖基化修饰影响腭成骨发育
Zhongyin Zhang,Zerui Shan,Xinyu Chen et al.
Zhongyin Zhang et al.
Post-translational modifications (PTMs) have been gradually elucidated in congenital malformations such as cleft palate. Among them, O-GlcNAcylation as a dynamic PTM of proteins regulates various critical biological processes including tran...
Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study [0.03%]
牙周炎与早期慢性肾脏病患者肾功能降低和尿蛋白之间的关联：一项基于人口的调查研究
Christian Schmidt-Lauber,Merle Ebinghaus,Katrin Borof et al.
Christian Schmidt-Lauber et al.
Periodontitis has been linked to chronic kidney disease (CKD) through systemic inflammation. However, evidence in early CKD remains limited. We analyzed 6 179 participants from a population-based cohort (median age 62 years; 51% women). Per...