Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice [0.03%]
琥珀酸通过琥珀酸受体1依赖机制调节老年小鼠口腔菌群失调和炎症反应
Fangxi Xu,Yuqi Guo,Scott C Thomas et al.
Fangxi Xu et al.
Aging involves the accumulation of various forms of molecular and cellular damage over time. Key features of aging, such as mitochondrial dysfunction, dysbiosis, and oxidative stress, are closely linked and largely driven by inflammation. T...
Expert consensus on management of instrument separation in root canal therapy [0.03%]
根管治疗器械分离的处理专家共识
Yi Fan,Yuan Gao,Xiangzhu Wang et al.
Yi Fan et al.
Instrument separation is a critical complication during root canal therapy, impacting treatment success and long-term tooth preservation. The etiology of instrument separation is multifactorial, involving the intricate anatomy of the root c...
Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons [0.03%]
牙科初级感觉神经元中Piezo2介导的机械转导的功能和独特作用
Pa Reum Lee,Kihwan Lee,Ji Min Park et al.
Pa Reum Lee et al.
Piezo2, a mechanosensitive ion channel, serves as a crucial mechanotransducer in dental primary afferent (DPA) neurons and is potentially involved in hypersensitivity to mild mechanical irritations observed in dental patients. Given Piezo2'...
The research progress on periodontitis by the National Natural Science Foundation of China [0.03%]
我国国家自然科学基金资助的牙周病学研究进展
Liang Xie,Qian Chen,Hao Xu et al.
Liang Xie et al.
Periodontitis has emerged as one of the most critical oral diseases, and research on this condition holds great importance for the advancement of stomatology. As the most authoritative national scientific research funding institution in Chi...
Physiologically relevant coculture model for oral microbial-host interactions [0.03%]
口腔微生物-宿主互作的生理相关共培养模型
Zeyang Pang,Nicole M Cady,Lujia Cen et al.
Zeyang Pang et al.
Understanding microbial-host interactions in the oral cavity is essential for elucidating oral disease pathogenesis and its systemic implications. In vitro bacteria-host cell coculture models have enabled fundamental studies to characterize...
Author Correction: Organoids in the oral and maxillofacial region: present and future [0.03%]
作者更正：口腔和颌面部类器官的现状与未来
Yufei Wu,Xiang Li,Hanzhe Liu et al.
Yufei Wu et al.
Published Erratum
International journal of oral science. 2025 May 27;17(1):43. DOI:10.1038/s41368-025-00377-5 2025
Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis [0.03%]
骨模素通过白细胞介素-1受体1/核因子-κB信号途径调节牙髓炎的炎症反应
Yueyi Yang,Xuchen Hu,Meiling Jing et al.
Yueyi Yang et al.
Pulpitis is a common infective oral disease in clinical situations. The regulatory mechanisms of immune defense in pulpitis are still being investigated. Osteomodulin (OMD) is a small leucine-rich proteoglycan family member distributed in b...
Single-cell and spatial transcriptomics reveals an anti-tumor neutrophil subgroup in microwave thermochemotherapy-treated lip cancer [0.03%]
单细胞和空间转录组揭示微波热化疗治疗唇癌中具有抗肿瘤作用的中性粒细胞亚群
Bingjun Chen,Huayang Fan,Xin Pang et al.
Bingjun Chen et al.
Microwave thermochemotherapy (MTC) has been applied to treat lip squamous cell carcinoma (LSCC), but a deeper understanding of its therapeutic mechanisms and molecular biology is needed. To address this, we used single-cell transcriptomics ...
Profiling and functional characterization of long noncoding RNAs during human tooth development [0.03%]
人牙发育过程中长链非编码RNA的特征分析及功能表征
Xiuge Gu,Wei Wei,Chuan Wu et al.
Xiuge Gu et al.
The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs (lncRNAs). However, the dynamics of lncRNA expression during human tooth development remain poorly understood. In this research,...
Expansion of functional human salivary acinar cell spheroids with reversible thermo-ionically crosslinked 3D hydrogels [0.03%]
具有可逆热离子交联的三维水凝胶的人涎腺腺泡细胞球体的扩增
Jose G Munguia-Lopez,Sangeeth Pillai,Yuli Zhang et al.
Jose G Munguia-Lopez et al.
Xerostomia (dry mouth) is frequently experienced by patients treated with radiotherapy for head and neck cancers or with Sjögren's syndrome, with no permanent cure existing for this debilitating condition. To this end, in vitro platforms a...