Eun-Jung Kim,Hyun-Yi Kim,Suyeon Lee et al.
Eun-Jung Kim et al.
Positional information plays a crucial role in embryonic pattern formation, yet its role in tooth development remains unexplored. In this study, we investigated the regional specification of lingual and buccal dental mesenchyme during tooth...
An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair [0.03%]
一种促进神经再生的生物陶瓷复合水凝胶用于修复牙髓-牙本质复合体损伤
Xingyu Tao,Hongjian Zhang,Peng Mei et al.
Xingyu Tao et al.
Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of ...
PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development [0.03%]
PLAGL1-IGF2轴调节产后髁突发育的骨发生作用
Jinrui Sun,Jingyi Xu,Yue Xu et al.
Jinrui Sun et al.
The mandibular condyle is a critical growth center in craniofacial bone development, especially during postnatal stages. Postnatal condyle osteogenesis requires precise spatiotemporal coordination of growth factor signaling cascades and hie...
LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer [0.03%]
长链非编码RNA EUDAL通过重塑缺氧诱导的表皮生长因子受体组成型活化来促进口腔癌耐药性形成
Shengkai Chen,Zhenlin Dai,Jianbo Shi et al.
Shengkai Chen et al.
Hypoxia and aberrant activation of epidermal growth factor receptor (EGFR) are considered important features of various malignancies. However, whether hypoxia can directly trigger EGFR activation and its clinical implications remain unclear...
Local abaloparatide administration promotes in situ alveolar bone augmentation via FAK-mediated periosteal osteogenesis [0.03%]
局部应用abaloparatide通过FAK介导的骨膜成骨促进原位牙槽骨增量
Ruyi Wang,Yuan Li,Bowen Tan et al.
Ruyi Wang et al.
Insufficient alveolar bone thickness increases the risk of periodontal dehiscence and fenestration, especially in orthodontic tooth movement. Abaloparatide (ABL), a synthetic analog of human PTHrP (1-34) and a clinical medication for treati...
Expert consensus on the treatment of oral diseases in pregnant women and infants [0.03%]
孕妇及婴幼儿口腔疾病治疗专家共识
Jun Zhang,Chenchen Zhou,Liwei Zheng et al.
Jun Zhang et al.
With the growing emphasis on maternal and child oral health, the significance of managing oral health across preconception, pregnancy, and infancy stages has become increasingly apparent. Oral health challenges extend beyond affecting mater...
Ye Liang,Hongrui Liu,Chengjia Xie et al.
Ye Liang et al.
Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as ver...
Single-cell spatial atlas of smoking-induced changes in human gingival tissues [0.03%]
吸烟引起的人体牙龈组织单细胞空间图谱
Yong Zhang,Zongshan Shen,Jiayu Yang et al.
Yong Zhang et al.
Smoking is a well-established risk factor for periodontitis, yet the precise mechanisms by which smoking contributes to periodontal disease remain poorly understood. Recent advances in spatial transcriptomics have enabled a deeper explorati...
Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy [0.03%]
经治疗诱导的衰老细胞的持续积累：长期癌症治疗有效性的障碍
Jingjing Luo,Tongxu Sun,Zhenghui Liu et al.
Jingjing Luo et al.
In the ever-evolving landscape of cancer therapy, while cancer treatments such as chemotherapy, radiotherapy, and targeted therapy aim to eradicate malignant cells, they also inadvertently trigger cellular senescence in both cancerous and m...
Yue Feng,Zhihong Feng,Jing Li et al.
Yue Feng et al.
Digital technologies have become an integral part of complete denture restoration. With advancement in computer-aided design and computer-aided manufacturing (CAD/CAM), tools such as intraoral scanning, facial scanning, 3D printing, and num...