JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities [0.03%]
jak-stat信号转导：颌面发育异常的分子机制和靶向治疗
Zihan Huang,Yiwen Cui,Wenyi Zhang et al.
Zihan Huang et al.
Dento-maxillofacial abnormalities are highly prevalent and arise as a result of a variety of etiological factors, presenting substantial challenges to treatment. The JAK-STAT signaling plays a pivotal role in dentofacial development, regula...
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion [0.03%]
具有GKG连接子的生物工程α-发夹肽TKH：一种LLPS介导的仿生矿化系统，用于牙本质小管内的矿化和深层牙本质小管封闭
Yeling Ou,Jing Wang,Luoyao Wang et al.
Yeling Ou et al.
Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abrasion or demineralization. For an effective long-term therapeutic desensitizing agent, the ability to achieve deep tub...
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux [0.03%]
订正：反义寡核苷酸靶向TARDBP-EGFR剪接轴通过ABCA1调控的胆固醇流出抑制口腔鳞状细胞癌的发展进展
Nan Ni,Moxu Wang,Zhiran Yuan et al.
Nan Ni et al.
Published Erratum
International journal of oral science. 2026 Mar 4;18(1):27. DOI:10.1038/s41368-026-00434-7 2026
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation [0.03%]
KDM6B/Pdk1糖酵解途径驱动的ZEB2乳酸化促进细胞牙本质形成
Zhengkun Yang,Huiyi Wang,Junhong Xiao et al.
Zhengkun Yang et al.
Periodontitis is a common chronic inflammatory disease that ultimately results in irreversible tooth loss. Cementum, a bone-like tissue surrounding tooth roots, deteriorates as periodontitis advances, ultimately causing tooth loss. Therefor...
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration [0.03%]
可溶性Notch激动剂促进人成釉细胞分化及类牙本质和类牙釉质组织的形成
Anjali P Patni,Rubul Mout,Ammar Alghadeer et al.
Anjali P Patni et al.
Enamel, the hardest mineralized material in the human body, protects the underlying living tissues, the dentin and pulp of the tooth. However, over 90% of adults have lost or damaged enamel and cannot regenerate the protective structure due...
Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder [0.03%]
单细胞转录图谱揭示了不同类型咬合障碍诱导的颞下颌关节骨关节炎中免疫细胞与软骨细胞之间的交叉对话机制
Kang Wang,Yusi Li,Shuaixi Xiang et al.
Kang Wang et al.
Temporomandibular joint (TMJ) osteoarthritis (OA) is a progressive degenerative disease in which the intricate mechanisms of the condyle cartilage damage are yet to be disclosed. A detailed characterization of cellular composition and signa...
ANKRD1 sustains a neurogenic BMSC niche and counters cognitive aging [0.03%]
ANKRD1维持神经发生BMSC生态位并对抗认知衰老
Zifei Wang,Xiaoyun Liu,Wenyu Zhen et al.
Zifei Wang et al.
Craniomaxillofacial bone marrow mesenchymal stromal cells (BMSCs) retaining neural crest-derived neurogenic niche is driven by lineage memory and niche homeostasis. Elucidating how the neurogenic potential is maintained is critical for neur...
Identification of GLDN+ odontogenic stem cells as crucial for human tooth development and regeneration [0.03%]
识别出GLDN+牙源性干细胞在人牙发育和再生中的重要作用
Chengcheng Liao,Jinglun Liu,Maojiao Li et al.
Chengcheng Liao et al.
The dental papilla (DP) is essential for the development of dentin and pulp. The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures during odontogenesis. How...
DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries [0.03%]
基于DNA和RNA的扩增子测序配对龈上菌斑与儿童严重早期儿童龋齿牙本质病损中的微生物群落差异
Allison A Naumann,Elissa M Elmorr,Eleanor I Lamont et al.
Allison A Naumann et al.
Early childhood caries is a form of tooth decay in children under the age of 6 and impacts more than 514 million children worldwide. Severe early childhood caries (S-ECC) represents the most advanced and aggressive form of early childhood c...
Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction [0.03%]
种植体通过Snx5-EGFR轴介导的机械转导唤醒peri-implant骨形成潜能
Xue Jiang,Yuteng Weng,Yanhuizhi Feng et al.
Xue Jiang et al.
Alveolar bone resorption during the socket healing process compromises subsequent restoration outcomes. Recent clinical evidence suggests that dental implant placement can effectively prevent such bone loss, yet the mechanisms remain elusiv...