Targeting IFN-I driven tertiary lymphoid structures halts B cell-mediated bone loss in periodontitis [0.03%]
靶向IFN-I驱动的三级淋巴组织可阻止牙周炎中的B细胞介导的骨丢失
Jiawei Lu,Xiao Wu,Zehui Xiong et al.
Jiawei Lu et al.
Lymphocytes play a central role in adaptive immunity and represent the primary source of RANKL in periodontitis. Understanding their organization and activation within gingiva is therefore essential. This study investigates the role of tert...
Enhancing pulp regeneration through metabolic reprogramming of mature dental pulp stem cells mediated by GLUT1/HK2 mRNA delivery [0.03%]
通过GLUT1/HK2 mRNA递送介导的成熟牙髓干细胞代谢重编程增强牙髓再生
Tiankai Di,Yuhan Liu,Zhili Li et al.
Tiankai Di et al.
The age-related decline in the pro-angiogenic capacity of mature dental pulp stem cells (DPSCs) severely limits pulp regeneration. We identify impaired glycolytic metabolism, driven by reduced glucose transporter type 1 (GLUT1) and hexokina...
Author Correction: KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation [0.03%]
作者更正：KDM6B/Pdk1糖酵解途径驱动的ZEB2乳酸化促进细胞牙本质形成
Zhengkun Yang,Huiyi Wang,Junhong Xiao et al.
Zhengkun Yang et al.
Published Erratum
International journal of oral science. 2026 Jul 15;18(1):51. DOI:10.1038/s41368-026-00453-4 2026
CHAC2-mediated glutathione metabolic reprogramming drives N1 polarization of bone marrow neutrophils and exacerbates inflammatory comorbidities [0.03%]
CHAC2介导的谷胱甘肽代谢重编程驱动骨髓中性粒细胞N1极化并加重炎症并发症
Yuting Niu,Yuman Li,Shiyu Sun et al.
Yuting Niu et al.
The proinflammatory (N1) polarization of bone marrow (BM) neutrophils, driven by central immune remodeling in response to peripheral inflammation, plays a critical role in propagating localized inflammatory conditions, such as periodontitis...
P. gingivalis-host interactions direct antibiotic adjuvants for periodontitis antimicrobial therapy [0.03%]
牙龈卟啉单胞菌-宿主互作指导抗生素辅助治疗牙周炎抗菌疗法
Xiya Liu,Zuoying Yuan,Zhuo Wan et al.
Xiya Liu et al.
Porphyromonas gingivalis (P. gingivalis) invades host cells to evade antibiotics, driving the recurrence of periodontitis. However, current clinical treatment strategies remain ineffective in addressing this intracellular invasion by the ba...
Autonomous robotic execution of nonlinear toolpaths for geometry-matched osteotomy in tooth autotransplantation: an in vitro study [0.03%]
用于牙齿自移植的匹配几何骨切削的非线性工具路径的自主机器人执行：体外研究
Chen Liu,Guangwei Chen,Libin Zhou et al.
Chen Liu et al.
Tooth autotransplantation requires recipient socket preparation that matches donor root morphology while preserving surrounding bone. We developed an autonomous multi-axis robotic system that executes nonlinear, surface-conforming milling t...
Inflammatory myofibroblasts reprogram neutrophil fate to drive chronic inflammation in peri-implantitis [0.03%]
牙周炎中的炎症肌成纤维细胞重塑中性粒细胞命运以驱动慢性炎症
Weimin Lin,Bassam A Altayar,Shuang Jiang et al.
Weimin Lin et al.
Peri-implantitis (PI) is a multifactorial chronic inflammatory disease characterized by persistent mucosal inflammation and progressive marginal bone loss, yet the tissue architecture and cellular programs that sustain chronic inflammation ...
The YTHDC1-m6A-GADD45B axis promotes chondrogenesis of hPDLSCs via suppressing senescence through p53/p21 signalling pathway [0.03%]
YTHDC1-m6A-GADD45B轴通过p53 / p21信号通路抑制衰老促进人牙周膜干细胞成软骨分化
Dan Tan,Qianke Tao,Luwen Ye et al.
Dan Tan et al.
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with limited therapeutic options. Stem cell-based tissue engineering, particularly utilizing human periodontal ligament stem cells (hPDLSCs), represents a promising ap...
Expert consensus on treatment of condylar hyperplasia and secondary dento-maxillofacial deformities [0.03%]
髁突肥大与继发颜面畸形的外科治疗专家共识
Ruiye Bi,Bassam M Abotaleb,Xiaofeng Bai et al.
Ruiye Bi et al.
Condylar hyperplasia (CH), characterized by progressive facial deviation, occlusion disorders, and temporomandibular joint dysfunction, often requires combined temporomandibular joint (TMJ)-orthognathic interventions to reconstruct joint an...
OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres [0.03%]
OCT4驱动的PER1活化促进衰老SCAP球体向牙源性分化
Changfang Li,Zibin Zhang,Zhuoxin Yang et al.
Changfang Li et al.
Mesenchymal stem cells (MSCs) hold significant promise for applications in regenerative medicine, yet their therapeutic potential is often limited by replicative senescence. Identifying effective strategies to reverse replicative senescence...