Expansion of functional human salivary acinar cell spheroids with reversible thermo-ionically crosslinked 3D hydrogels [0.03%]
具有可逆热离子交联的三维水凝胶的人涎腺腺泡细胞球体的扩增
Jose G Munguia-Lopez,Sangeeth Pillai,Yuli Zhang et al.
Jose G Munguia-Lopez et al.
Xerostomia (dry mouth) is frequently experienced by patients treated with radiotherapy for head and neck cancers or with Sjögren's syndrome, with no permanent cure existing for this debilitating condition. To this end, in vitro platforms a...
Community dynamics during de novo colonization of the nascent peri-implant sulcus [0.03%]
种植体表面唾液接触区微生物群的从头定植及早期变化规律研究
Tamires Pereira Dutra,Nicolas Robitaille,Khaled Altabtbaei et al.
Tamires Pereira Dutra et al.
Dental implants have restored masticatory function to over 100 000 000 individuals, yet almost 1 000 000 implants fail each year due to peri-implantitis, a disease triggered by peri-implant microbial dysbiosis. Our ability to prevent and tr...
Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B [0.03%]
下颌来源的细胞外囊泡通过靶向KDM2B调控 miniature pig早期牙发育
Ye Li,Meng Sun,Yi Ding et al.
Ye Li et al.
Tissue interactions play a crucial role in tooth development. Notably, extracellular vesicle-mediated interactions between the mandible and tooth germ are considered essential. Here, we revealed that mandible extracellular vesicles could mo...
Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane [0.03%]
单细胞测序技术系统分析Emdogain修复延期再植牙周膜的作用机制
Yanyi Liu,Yuhao Peng,Lanhui Chen et al.
Yanyi Liu et al.
The repair of the periodontal membrane is essential for the successful management of periodontal disease and dental trauma. Emdogain® (EMD) is widely used in periodontal therapy due to its ability to promote repair. Despite substantial res...
Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via NF-κB activation [0.03%]
NF-κB激活介导的炎性降解胶原纤维参与翼外肌炎性反应致颞下颌关节盘移位的病理过程
Shengjie Cui,Yanning Guo,Yu Fu et al.
Shengjie Cui et al.
Temporomandibular joint (TMJ) disc displacement is one of the most significant subtypes of temporomandibular joint disorders, but its etiology and mechanism are poorly understood. In this study, we elucidated the mechanisms by which destruc...
NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming [0.03%]
NUP62通过NSD2依赖的表观遗传重编程缓解人类牙髓干细胞衰老并促进其干细胞特性
Xiping Wang,Li Wang,Linxi Zhou et al.
Xiping Wang et al.
Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis. However, mechanisms associated with stem cell senescence require further investigation. In this study, we conducted a proteomic analysis of human de...
Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy [0.03%]
富马酸二甲酯通过增加TUFM介导的线粒体自噬来调节M1 / M2巨噬细胞极化以缓解牙周破坏
Liang Chen,Pengxiao Hu,Xinhua Hong et al.
Liang Chen et al.
Periodontitis is a common oral disease characterized by progressive alveolar bone resorption and inflammation of the periodontal tissues. Dimethyl fumarate (DMF) has been used in the treatment of various immune-inflammatory diseases due to ...
Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression [0.03%]
组蛋白去甲基化酶KDM1通过CDK7磷酸化调控STAT3在头颈部鳞癌发生发展及免疫抑制中的作用机制研究
Amit Kumar Chakraborty,Rajnikant Dilip Raut,Kisa Iqbal et al.
Amit Kumar Chakraborty et al.
Oral squamous cell carcinoma (OSCC) progresses from preneoplastic precursors via genetic and epigenetic alterations. Previous studies have focused on the treatment of terminally developed OSCC. However, the role of epigenetic regulators as ...
Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation [0.03%]
成纤维细胞衍生的补体C3通过促进巨噬细胞M1极化和破骨细胞分化来促进实验性牙周炎的发展
Feilong Ren,Shize Zheng,Huanyu Luo et al.
Feilong Ren et al.
Complement C3 plays a critical role in periodontitis. However, its source, role and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that C3 is pri...
Programmed death-ligand 1 regulates ameloblastoma growth and recurrence [0.03%]
程序性死亡配体1调节成釉细胞瘤的生长和复发
Linzhou Zhang,Hao Lin,Jiajie Liang et al.
Linzhou Zhang et al.
Tumor cell-intrinsic programmed death-ligand 1 (PD-L1) signals mediate tumor initiation, progression and metastasis, but their effects in ameloblastoma (AM) have not been reported. In this comprehensive study, we observed marked upregulatio...