LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer [0.03%]
长链非编码RNA EUDAL通过重塑缺氧诱导的表皮生长因子受体组成型活化来促进口腔癌耐药性形成
Shengkai Chen,Zhenlin Dai,Jianbo Shi et al.
Shengkai Chen et al.
Hypoxia and aberrant activation of epidermal growth factor receptor (EGFR) are considered important features of various malignancies. However, whether hypoxia can directly trigger EGFR activation and its clinical implications remain unclear...
Local abaloparatide administration promotes in situ alveolar bone augmentation via FAK-mediated periosteal osteogenesis [0.03%]
局部应用abaloparatide通过FAK介导的骨膜成骨促进原位牙槽骨增量
Ruyi Wang,Yuan Li,Bowen Tan et al.
Ruyi Wang et al.
Insufficient alveolar bone thickness increases the risk of periodontal dehiscence and fenestration, especially in orthodontic tooth movement. Abaloparatide (ABL), a synthetic analog of human PTHrP (1-34) and a clinical medication for treati...
Expert consensus on the treatment of oral diseases in pregnant women and infants [0.03%]
孕妇及婴幼儿口腔疾病治疗专家共识
Jun Zhang,Chenchen Zhou,Liwei Zheng et al.
Jun Zhang et al.
With the growing emphasis on maternal and child oral health, the significance of managing oral health across preconception, pregnancy, and infancy stages has become increasingly apparent. Oral health challenges extend beyond affecting mater...
Ye Liang,Hongrui Liu,Chengjia Xie et al.
Ye Liang et al.
Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as ver...
Single-cell spatial atlas of smoking-induced changes in human gingival tissues [0.03%]
吸烟引起的人体牙龈组织单细胞空间图谱
Yong Zhang,Zongshan Shen,Jiayu Yang et al.
Yong Zhang et al.
Smoking is a well-established risk factor for periodontitis, yet the precise mechanisms by which smoking contributes to periodontal disease remain poorly understood. Recent advances in spatial transcriptomics have enabled a deeper explorati...
Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy [0.03%]
经治疗诱导的衰老细胞的持续积累：长期癌症治疗有效性的障碍
Jingjing Luo,Tongxu Sun,Zhenghui Liu et al.
Jingjing Luo et al.
In the ever-evolving landscape of cancer therapy, while cancer treatments such as chemotherapy, radiotherapy, and targeted therapy aim to eradicate malignant cells, they also inadvertently trigger cellular senescence in both cancerous and m...
Yue Feng,Zhihong Feng,Jing Li et al.
Yue Feng et al.
Digital technologies have become an integral part of complete denture restoration. With advancement in computer-aided design and computer-aided manufacturing (CAD/CAM), tools such as intraoral scanning, facial scanning, 3D printing, and num...
c-Kit signaling confers damage-resistance to sweet taste cells upon nerve injury [0.03%]
神经损伤时c-Kit信号使甜味细胞获得抵抗损伤的能力
Su Young Ki,Jea Hwa Jang,Dong-Hoon Kim et al.
Su Young Ki et al.
Taste buds relay taste sensory information to the primary taste neurons but depend on those same neurons for essential components to maintain function. While denervation-induced taste bud degeneration and subsequent regeneration were discov...
Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration [0.03%]
单细胞转录组揭示PDGFRA阳性祖细胞协调牙周组织再生中的血管生成的作用
Jianing Liu,Junxi He,Ziqi Zhang et al.
Jianing Liu et al.
Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative med...
Saliva as a non-invasive matrix for assessing xenobiotic metabolites and metabolomes: implications for maternal health and preeclampsia [0.03%]
唾液作为评估外源性代谢物和代谢组的非侵入性介质：对母体健康和子痫前期的意义
Preethi Balan,Junfeng Zhang,Kok Hian Tan et al.
Preethi Balan et al.
Chemical exposure during prenatal development has significant implications for both maternal and child health. Compared to blood, saliva is a non-invasive and less resource-intensive, alternative. Given the temporal variability of xenobioti...