SMAD7 regulates the canonical Wnt signaling through TGF-β cascade crosstalk and SMAD7/β-CATENIN transcription factor complex formation during tooth regeneration [0.03%]
SMAD7通过TGF-β信号通路串扰和SMAD7/β-CATENIN转录因子复合物的形成调节 canonical Wnt 信号通路在牙齿再生中的作用
Qiuyu Chen,Zhi Liu,Bohuai Zhou et al.
Qiuyu Chen et al.
Tooth morphogenesis is orchestrated by a complex interplay of signaling pathways and transcription factors that control cell proliferation, apoptosis, and differentiation, with the Wnt/β-catenin signaling pathway playing a pivotal role. Ho...
Structure insight into FtsZ function maintaining under acid stress of Streptococcus mutans [0.03%]
酸胁迫下齿垢密螺旋体FtsZ蛋白结构及功能研究初探
Yuxing Chen,Yongliang Li,Jiahao Niu et al.
Yuxing Chen et al.
Understanding the acid resistance mechanism of S. mutans is crucial for preventing dental caries. FtsZ is the core protein for cell division in bacteria that can polymerize into Z-rings and drive cytokinesis. Our previous study revealed tha...
Next-generation craniomaxillofacial implants for reconstructive surgery: balancing biomechanics, biocompatibility, and bioactivity [0.03%]
下一代颅面植入物在重建手术中的应用：兼顾生物力学、生物相容性和生物活性
Bozhi Hou,Yuehua Li,Raymond Chung Wen Wong
Bozhi Hou
Next-generation craniomaxillofacial implants (CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics, biocompatibility, and bioactivity-the "3Bs". This review highlights recent progress in implant de...
Progressive tooth pattern changes in Cilk1-deficient mice depending on Hedgehog signaling [0.03%]
Hedgehog信号对Cilk1缺陷型小鼠进行性齿式变化的影响
Minjae Kyeong,Ju-Kyung Jeong,Dinuka Adasooriya et al.
Minjae Kyeong et al.
Primary cilia function as critical sensory organelles that mediate multiple signaling pathways, including the Hedgehog (Hh) pathway, which is essential for organ patterning and morphogenesis. Disruptions in Hh signaling have been implicated...
Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients [0.03%]
精氨酸调节龋齿活性患者菌斑的pH值、微生物组成和基质结构
Yumi C Del Rey,Pernille D Rikvold,Marie B Lund et al.
Yumi C Del Rey et al.
The caries-preventive effects of arginine have been attributed to its impact on biofilm composition and pH. Recent in vitro studies suggest that arginine also affects the production of biofilm matrix components that contribute to virulence,...
Randomized Controlled Trial
International journal of oral science. 2025 Nov 20;17(1):70. DOI:10.1038/s41368-025-00404-5 2025
Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response [0.03%]
牙周病变期间伴放线杆菌诱导的糖耐量异常需要其脂多糖并通过Th17免疫反应实现
Sylvie Lê,Emma Sturaro,Charlotte Thomas et al.
Sylvie Lê et al.
This study investigates the role of Interleukin 17 (IL-17) in exacerbating periapical lesions caused by Porphyromonas gingivalis (Pg) lipopolysaccharides (LPS) in the context of metabolic disease and its potential impact on glucose toleranc...
Thymosin α1 alleviates pulpitis by inhibiting ferroptosis of dental pulp cells [0.03%]
胸腺素α1通过抑制牙髓细胞铁死亡治疗牙髓炎
Jie Wu,Qimei Gong,Wenxuan Liu et al.
Jie Wu et al.
Tooth pulpitis is a prevalent oral disorder. Understanding the underlying mechanisms of pulpitis and developing effective treatment strategies hold great significance. Ferroptosis has recently emerged as a new form of cell death, but the ro...
Eun-Jung Kim,Hyun-Yi Kim,Suyeon Lee et al.
Eun-Jung Kim et al.
Positional information plays a crucial role in embryonic pattern formation, yet its role in tooth development remains unexplored. In this study, we investigated the regional specification of lingual and buccal dental mesenchyme during tooth...
An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair [0.03%]
一种促进神经再生的生物陶瓷复合水凝胶用于修复牙髓-牙本质复合体损伤
Xingyu Tao,Hongjian Zhang,Peng Mei et al.
Xingyu Tao et al.
Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of ...
PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development [0.03%]
PLAGL1-IGF2轴调节产后髁突发育的骨发生作用
Jinrui Sun,Jingyi Xu,Yue Xu et al.
Jinrui Sun et al.
The mandibular condyle is a critical growth center in craniofacial bone development, especially during postnatal stages. Postnatal condyle osteogenesis requires precise spatiotemporal coordination of growth factor signaling cascades and hie...