LOXL2 deletion triggers TMJ osteoarthritis, while overexpression protects it from NF-κB-induced chondrocyte apoptosis [0.03%]
LOXL2缺失诱发关节骨关节炎，而过表达保护其免受NF-κB诱导的软骨细胞凋亡
Rajnikant Dilip Raut,Chumki Choudhury,Faiza Ali et al.
Rajnikant Dilip Raut et al.
Temporomandibular joint osteoarthritis (TMJ-OA) affects a significant proportion of the population worldwide. However, there has been no substantial progress in the development of FDA-approved drugs for treatment due to a lack of understand...
Enamel decussation pattern originates from directional sliding of ameloblasts [0.03%]
釉质交叉模式由AMELOBLASTS的定向滑动产生
Vladislav Rakultsev,Josef Lavicky,Marcos Gonzalez Lopez et al.
Vladislav Rakultsev et al.
Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastr...
Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism [0.03%]
铜死亡通过GYS1介导的糖原代谢促进炎性骨溶解
Lu Zhou,Hanqing Mao,Yuanhao Wen et al.
Lu Zhou et al.
Copper, predominantly present in bones, plays a crucial role in bone formation. However, when copper homeostasis is disrupted, excessive copper can trigger harmful inflammation and a novel form of cell death known as cuproptosis. The impact...
Partial-EMT in oral squamous cell carcinoma: molecular circuitry and clinical translation [0.03%]
口腔鳞状细胞癌中的部分上皮间质转化：分子回路和临床转化
Chunhua Wang,Motoharu Sarubo,Siqi Chen et al.
Chunhua Wang et al.
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with high morbidity and mortality. Globally, about 400 000 people are affected, often with a poor quality of life. Its high mortality is mainly due to its aggressive growth and t...
Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice [0.03%]
牙龈炎相关口腔微生物群通过调节肠道和抑制色氨酸代谢加剧卵巢切除小鼠系统性破骨细胞生成
Nannan Wang,Jun Qian,Min Wang et al.
Nannan Wang et al.
Epidemiological studies have highlighted an association between periodontitis and osteoporosis. However, the mechanism underlining this association remains unclear. Here, we revealed significant differences in the salivary microbiota betwee...
Expert consensus on the diagnosis and management of tooth developmental anomalies [0.03%]
牙发育异常的诊断与处理专家共识
Jingxian Zhu,Mian Wan,Xiaohong Duan et al.
Jingxian Zhu et al.
Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process, resulting in abnormalities in tooth number, structure, and morphology. These anomalies typically manifest during c...
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux [0.03%]
靶向TARDBP-EGFR剪接轴的反义寡核苷酸通过ABCA1调节胆固醇流出抑制舌鳞状细胞癌进展
Nan Ni,Moxu Wang,Zhiran Yuan et al.
Nan Ni et al.
Splice quantitative trait loci (sQTL) serve as another critical link between genetic variations and human diseases, besides expression quantitative trait loci (eQTL). Their role in oral squamous cell carcinoma (OSCC) development remains une...
Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells [0.03%]
Wnt3a通过NKD1-MSX1轴介导的牙髓干细胞成odontogenic分化促进原位牙本质形成
Haoran Du,Qiong Li,Chenchen Zhou et al.
Haoran Du et al.
The functional regeneration of the dentin-pulp complex is pivotal for tooth preservation, yet the molecular mechanisms governing odontoblast differentiation remain poorly understood. In the current study, we revealed a distinct NKD1+ subpop...
MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD [0.03%]
MARCH2通过泛素化PTPRD抑制成牙本质细胞分化
Hao Feng,Jiaxin Niu,Zhi Chen et al.
Hao Feng et al.
Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein...
Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function [0.03%]
牙龈卟啉单胞菌通过影响中性粒细胞趋化和功能促进慢性阻塞性肺病发展
Luyao Zhang,Huan Tian,Yuanyuan Ma et al.
Luyao Zhang et al.
Chronic obstructive pulmonary disease (COPD), a disease responsible for early mortality worldwide, is well accepted to be associated with periodontitis epidemiologically. Although both of the diseases are the multi-microbial inflammatory di...