Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients [0.03%]
精氨酸调节龋齿活性患者菌斑的pH值、微生物组成和基质结构
Yumi C Del Rey,Pernille D Rikvold,Marie B Lund et al.
Yumi C Del Rey et al.
The caries-preventive effects of arginine have been attributed to its impact on biofilm composition and pH. Recent in vitro studies suggest that arginine also affects the production of biofilm matrix components that contribute to virulence,...
Randomized Controlled Trial
International journal of oral science. 2025 Nov 20;17(1):70. DOI:10.1038/s41368-025-00404-5 2025
Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response [0.03%]
牙周病变期间伴放线杆菌诱导的糖耐量异常需要其脂多糖并通过Th17免疫反应实现
Sylvie Lê,Emma Sturaro,Charlotte Thomas et al.
Sylvie Lê et al.
This study investigates the role of Interleukin 17 (IL-17) in exacerbating periapical lesions caused by Porphyromonas gingivalis (Pg) lipopolysaccharides (LPS) in the context of metabolic disease and its potential impact on glucose toleranc...
Thymosin α1 alleviates pulpitis by inhibiting ferroptosis of dental pulp cells [0.03%]
胸腺素α1通过抑制牙髓细胞铁死亡治疗牙髓炎
Jie Wu,Qimei Gong,Wenxuan Liu et al.
Jie Wu et al.
Tooth pulpitis is a prevalent oral disorder. Understanding the underlying mechanisms of pulpitis and developing effective treatment strategies hold great significance. Ferroptosis has recently emerged as a new form of cell death, but the ro...
Eun-Jung Kim,Hyun-Yi Kim,Suyeon Lee et al.
Eun-Jung Kim et al.
Positional information plays a crucial role in embryonic pattern formation, yet its role in tooth development remains unexplored. In this study, we investigated the regional specification of lingual and buccal dental mesenchyme during tooth...
An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair [0.03%]
一种促进神经再生的生物陶瓷复合水凝胶用于修复牙髓-牙本质复合体损伤
Xingyu Tao,Hongjian Zhang,Peng Mei et al.
Xingyu Tao et al.
Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of ...
PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development [0.03%]
PLAGL1-IGF2轴调节产后髁突发育的骨发生作用
Jinrui Sun,Jingyi Xu,Yue Xu et al.
Jinrui Sun et al.
The mandibular condyle is a critical growth center in craniofacial bone development, especially during postnatal stages. Postnatal condyle osteogenesis requires precise spatiotemporal coordination of growth factor signaling cascades and hie...
LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer [0.03%]
长链非编码RNA EUDAL通过重塑缺氧诱导的表皮生长因子受体组成型活化来促进口腔癌耐药性形成
Shengkai Chen,Zhenlin Dai,Jianbo Shi et al.
Shengkai Chen et al.
Hypoxia and aberrant activation of epidermal growth factor receptor (EGFR) are considered important features of various malignancies. However, whether hypoxia can directly trigger EGFR activation and its clinical implications remain unclear...
Local abaloparatide administration promotes in situ alveolar bone augmentation via FAK-mediated periosteal osteogenesis [0.03%]
局部应用abaloparatide通过FAK介导的骨膜成骨促进原位牙槽骨增量
Ruyi Wang,Yuan Li,Bowen Tan et al.
Ruyi Wang et al.
Insufficient alveolar bone thickness increases the risk of periodontal dehiscence and fenestration, especially in orthodontic tooth movement. Abaloparatide (ABL), a synthetic analog of human PTHrP (1-34) and a clinical medication for treati...
Expert consensus on the treatment of oral diseases in pregnant women and infants [0.03%]
孕妇及婴幼儿口腔疾病治疗专家共识
Jun Zhang,Chenchen Zhou,Liwei Zheng et al.
Jun Zhang et al.
With the growing emphasis on maternal and child oral health, the significance of managing oral health across preconception, pregnancy, and infancy stages has become increasingly apparent. Oral health challenges extend beyond affecting mater...
Ye Liang,Hongrui Liu,Chengjia Xie et al.
Ye Liang et al.
Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as ver...