DNA and RNA-based amplicon sequencing of paired supragingival and dentin lesion plaque in children with severe early childhood caries [0.03%]
基于DNA和RNA的扩增子测序配对龈上菌斑与儿童严重早期儿童龋齿牙本质病损中的微生物群落差异
Allison A Naumann,Elissa M Elmorr,Eleanor I Lamont et al.
Allison A Naumann et al.
Early childhood caries is a form of tooth decay in children under the age of 6 and impacts more than 514 million children worldwide. Severe early childhood caries (S-ECC) represents the most advanced and aggressive form of early childhood c...
Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction [0.03%]
种植体通过Snx5-EGFR轴介导的机械转导唤醒peri-implant骨形成潜能
Xue Jiang,Yuteng Weng,Yanhuizhi Feng et al.
Xue Jiang et al.
Alveolar bone resorption during the socket healing process compromises subsequent restoration outcomes. Recent clinical evidence suggests that dental implant placement can effectively prevent such bone loss, yet the mechanisms remain elusiv...
Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways [0.03%]
慢性牙科照明通过血管和炎症途径破坏血视网膜屏障稳态
Haiyang Sun,Shuhuai Meng,He Cai et al.
Haiyang Sun et al.
Excessive lighting is integral to dentists' daily routines but can impair their vision, affecting personal and professional performance. Most studies focus on acute photodamage, neglecting chronic photo-injury from dental lighting and its i...
Stimuli-responsive, antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration [0.03%]
口腔生物膜控制和微生物群恢复的抗菌载药刺激响应纳米载体
Ding Chen,Dize Li,Linzhu Su et al.
Ding Chen et al.
Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials. Here, nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon ...
Engineered Lactobacillus reuteri for scavenging reactive oxygen species and modulating oral microflora in periodontitis therapy [0.03%]
用于牙周炎治疗的工程乳酸菌罗伊氏杆菌除清除活性氧和调节口腔微生物群研究
Yuqiang Wang,Ying Tang,Qianxiao Huang et al.
Yuqiang Wang et al.
The onset and progression of periodontitis are closely associated with subgingival dysbiosis and excessive localized oxidative stress. While some oral probiotics exhibit certain inhibitory effects on periodontitis-related pathogens, they of...
Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis [0.03%]
牙龈卟啉单胞菌源性细胞外囊泡通过促进Syk依赖的破骨细胞分化加重类风湿关节炎骨破坏
Jiajie Guo,Qiujing Qiu,Xiaoyuan Yan et al.
Jiajie Guo et al.
Rheumatoid arthritis (RA) is an autoimmune disorder that triggers progressive joint destruction by inducing excessive osteoclastogenesis. Porphyromonas gingivalis (Pg), the main pathogenic bacterium involved in periodontitis (PD), is closel...
LOXL2 deletion triggers TMJ osteoarthritis, while overexpression protects it from NF-κB-induced chondrocyte apoptosis [0.03%]
LOXL2缺失诱发关节骨关节炎，而过表达保护其免受NF-κB诱导的软骨细胞凋亡
Rajnikant Dilip Raut,Chumki Choudhury,Faiza Ali et al.
Rajnikant Dilip Raut et al.
Temporomandibular joint osteoarthritis (TMJ-OA) affects a significant proportion of the population worldwide. However, there has been no substantial progress in the development of FDA-approved drugs for treatment due to a lack of understand...
Enamel decussation pattern originates from directional sliding of ameloblasts [0.03%]
釉质交叉模式由AMELOBLASTS的定向滑动产生
Vladislav Rakultsev,Josef Lavicky,Marcos Gonzalez Lopez et al.
Vladislav Rakultsev et al.
Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastr...
Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism [0.03%]
铜死亡通过GYS1介导的糖原代谢促进炎性骨溶解
Lu Zhou,Hanqing Mao,Yuanhao Wen et al.
Lu Zhou et al.
Copper, predominantly present in bones, plays a crucial role in bone formation. However, when copper homeostasis is disrupted, excessive copper can trigger harmful inflammation and a novel form of cell death known as cuproptosis. The impact...
Partial-EMT in oral squamous cell carcinoma: molecular circuitry and clinical translation [0.03%]
口腔鳞状细胞癌中的部分上皮间质转化：分子回路和临床转化
Chunhua Wang,Motoharu Sarubo,Siqi Chen et al.
Chunhua Wang et al.
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with high morbidity and mortality. Globally, about 400 000 people are affected, often with a poor quality of life. Its high mortality is mainly due to its aggressive growth and t...