Zhongyin Zhang,Zerui Shan,Xinyu Chen et al.
Zhongyin Zhang et al.
Post-translational modifications (PTMs) have been gradually elucidated in congenital malformations such as cleft palate. Among them, O-GlcNAcylation as a dynamic PTM of proteins regulates various critical biological processes including tran...
Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study [0.03%]
Christian Schmidt-Lauber,Merle Ebinghaus,Katrin Borof et al.
Christian Schmidt-Lauber et al.
Periodontitis has been linked to chronic kidney disease (CKD) through systemic inflammation. However, evidence in early CKD remains limited. We analyzed 6 179 participants from a population-based cohort (median age 62 years; 51% women). Per...
Hanqi Fu,Peng Chen,Zuping Wu et al.
Hanqi Fu et al.
Dental tissues development involves two distinct cell lineages: mesenchymal cells (derived from the cranial neural crest) and epithelial cells (derived from oral ectoderm and pharyngeal epithelium). Emerging evidence highlights the remarkab...
Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients [0.03%]
成人正畸结缔组织增量术专家共识
Runzhi Guo,Xiaotong Li,Jianxia Hou et al.
Runzhi Guo et al.
Alveolar bone defects, including dehiscence and fenestration, are commonly encountered in adult patients seeking orthodontic treatment. These anatomical deficiencies increase the risk of periodontal complications and may significantly compr...
Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models [0.03%]
基于机械应力和关节盘脱位模型定义颞下颌关节骨关节炎起始阶段的滑膜细胞器反应
Kazuhiro Shibusaka,Soichiro Negishi,Asuka Terashima et al.
Kazuhiro Shibusaka et al.
Temporomandibular joint osteoarthritis (TMJ-OA), the most common degenerative disease of the TMJ, is influenced by various adaptive, inflammatory, and mechanical stressors. In this study, we describe molecular alterations of the synovium of...
Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis [0.03%]
HH-TGF-β信号通路在牙根发育中的协同作用及其分子机制研究
Tao Zhou,Linyang Huang,Yaxin Xie et al.
Tao Zhou et al.
Hedgehog (HH) signaling is essential in directing the fate determination of postmigratory cranial neural crest cells (CNCCs) to ensure proper craniofacial development. Gli transcription factors (TFs) are established as primary effectors of ...
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities [0.03%]
jak-stat信号转导：颌面发育异常的分子机制和靶向治疗
Zihan Huang,Yiwen Cui,Wenyi Zhang et al.
Zihan Huang et al.
Dento-maxillofacial abnormalities are highly prevalent and arise as a result of a variety of etiological factors, presenting substantial challenges to treatment. The JAK-STAT signaling plays a pivotal role in dentofacial development, regula...
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion [0.03%]
具有GKG连接子的生物工程α-发夹肽TKH：一种LLPS介导的仿生矿化系统，用于牙本质小管内的矿化和深层牙本质小管封闭
Yeling Ou,Jing Wang,Luoyao Wang et al.
Yeling Ou et al.
Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abrasion or demineralization. For an effective long-term therapeutic desensitizing agent, the ability to achieve deep tub...
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux [0.03%]
订正：反义寡核苷酸靶向TARDBP-EGFR剪接轴通过ABCA1调控的胆固醇流出抑制口腔鳞状细胞癌的发展进展
Nan Ni,Moxu Wang,Zhiran Yuan et al.
Nan Ni et al.
Published Erratum
International journal of oral science. 2026 Mar 4;18(1):27. DOI:10.1038/s41368-026-00434-7 2026
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation [0.03%]
KDM6B/Pdk1糖酵解途径驱动的ZEB2乳酸化促进细胞牙本质形成
Zhengkun Yang,Huiyi Wang,Junhong Xiao et al.
Zhengkun Yang et al.
Periodontitis is a common chronic inflammatory disease that ultimately results in irreversible tooth loss. Cementum, a bone-like tissue surrounding tooth roots, deteriorates as periodontitis advances, ultimately causing tooth loss. Therefor...