The YTHDC1-m6A-GADD45B axis promotes chondrogenesis of hPDLSCs via suppressing senescence through p53/p21 signalling pathway [0.03%]
YTHDC1-m6A-GADD45B轴通过p53 / p21信号通路抑制衰老促进人牙周膜干细胞成软骨分化
Dan Tan,Qianke Tao,Luwen Ye et al.
Dan Tan et al.
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with limited therapeutic options. Stem cell-based tissue engineering, particularly utilizing human periodontal ligament stem cells (hPDLSCs), represents a promising ap...
Expert consensus on treatment of condylar hyperplasia and secondary dento-maxillofacial deformities [0.03%]
髁突肥大与继发颜面畸形的外科治疗专家共识
Ruiye Bi,Bassam M Abotaleb,Xiaofeng Bai et al.
Ruiye Bi et al.
Condylar hyperplasia (CH), characterized by progressive facial deviation, occlusion disorders, and temporomandibular joint dysfunction, often requires combined temporomandibular joint (TMJ)-orthognathic interventions to reconstruct joint an...
OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres [0.03%]
OCT4驱动的PER1活化促进衰老SCAP球体向牙源性分化
Changfang Li,Zibin Zhang,Zhuoxin Yang et al.
Changfang Li et al.
Mesenchymal stem cells (MSCs) hold significant promise for applications in regenerative medicine, yet their therapeutic potential is often limited by replicative senescence. Identifying effective strategies to reverse replicative senescence...
Kdf1 missense mutation caused enamel defects by disrupting cell adhesion and Hippo-YAP signaling in dental epithelium [0.03%]
牙釉质缺陷的分子机制研究取得新进展
Pei Li,Runling Zeng,Jingyan Xue et al.
Pei Li et al.
Amelogenesis imperfecta is a hereditary enamel defect arising from dental epithelium dysfunction. Although keratinocyte differentiation factor 1 (KDF1) acts as an intracellular regulator in epithelial cells, the underlying disease mechanism...
Osteoblast-derived CAR3 synergizing with collagen and bone sialoprotein enhances bone formation [0.03%]
成骨细胞衍生的CAR3与胶原和骨唾液蛋白协同作用促进骨形成
Xiaoxin Ma,Qing He,Chen Ye et al.
Xiaoxin Ma et al.
Osteoblasts orchestrate the infiltration and crystallization of mineral precursors within collagen fibrils. Certain osteoblast-secreted mineralization-inducing proteins further stimulate bone formation. In this study, scRNA-seq analysis of ...
Fuel to fire: developmental niche-empowered ApoEVs unlock adult hierarchical tissue regenerative potential via mitochondrial complex I-driven developmental metabolic profile [0.03%]
添油加薪：发育生态位增强的ApoE外囊体通过线粒体复合物I驱动的发育代谢谱解锁成年组织再生潜能
Yanshu Zhang,Jieyun Xu,Yuhan Shi et al.
Yanshu Zhang et al.
Organ defects involving hierarchical tissue structures remain a major challenge due to limited regenerative capacity in adulthood. To break this bottleneck, regenerative medicine is undergoing a paradigm shift from simulating the healing pr...
Machine learning-driven discovery of therapeutic nucleoside hydrogels for periodontitis [0.03%]
机器学习驱动的牙周炎治疗核糖核酸凝胶的发现
Weiqi Li,Yinghui Wen,Zhenyuan Huang et al.
Weiqi Li et al.
Supramolecular hydrogels hold significant potential in drug delivery and tissue engineering, with standing out for their unique properties. Despite their promise, predicting nucleoside bioactivity remains challenging. This study aims to pre...
DNA framework-based nanomedicine platform: a triple-function strategy for treating periodontitis via antibacterial, anti-inflammatory, and osteogenesis-promoting activities [0.03%]
一种基于DNA框架的纳米医药平台：通过抗菌、抗炎和促骨发生作用治疗牙周病的三重功能策略
Geru Zhang,Weitong Cui,Haoyan Wu et al.
Geru Zhang et al.
Periodontitis is the most prevalent chronic inflammatory condition affecting oral health and is associated with long treatment duration. It is triggered by microbial plaque, which leads to localized and diffuse inflammation, ultimately caus...
Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns [0.03%]
基于突变特征的分类揭示了具有不同分子模式的新兴口腔癌亚型
Sophie Deneuve,Béatrice Fervers,Julia S Bruno et al.
Sophie Deneuve et al.
Tobacco use, alcohol consumption, and infection with human papilloma virus (HPV) are well-established risk factors for head and neck squamous cell carcinomas (HNSCC). However, the incidence of oral cancer, particularly in the mobile tongue,...
Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation [0.03%]
单细胞多组学测序揭示了肠道菌群代谢产物丁酸介导痛觉调制的细胞特异性转录和染色质可及性图谱
Ran Tao,Sufang Liu,Joshua Crawford et al.
Ran Tao et al.
Pain is the most common symptom of temporomandibular joint (TMJ) disorders, which present significant clinical challenges due to their complexity and limited treatment options. Our previous study demonstrates that gut microbiome-derived but...