Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study [0.03%]
脯氨酰拉帕霉素的结构：通过修订和详细的NMR指认研究予以确认
Annalisa Mortoni,Eugenio Castelli,Teresa Recca et al.
Annalisa Mortoni et al.
A complete and detailed characterization of Rapamycin (1) and Prolylrapamycin (2) has been conducted by homo- and hetero-nuclear NMR experiments in DMSO-d6 along with HRMS and FT-IR spectra and DSCs analyses. The NMR experiments allowed the...
Pharmacokinetics, tissue distribution, bioavailability and excretion of the anti-virulence drug Fluorothiazinon in rats and rabbits [0.03%]
抗毒力药物氟噻嗪农在大鼠和兔体内的药代动力学、组织分布、生物利用度及排泄研究
Mark V Savitskii,Natalia E Moskaleva,Alex Brito et al.
Mark V Savitskii et al.
Growing antimicrobial resistance has accelerated the development of anti-virulence drugs to suppress bacterial toxicity without affecting cell viability. Fluorothiazinon (FT), an anti-virulence, type three secretion system and flagella moti...
Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes [0.03%]
产IMP酶细菌的传播与blaIMP基因启动子强度的相关性研究
Yuta Kikuchi,Mariko Yoshida,Asaomi Kuwae et al.
Yuta Kikuchi et al.
The first report of transmissible carbapenem resistance encoded by blaIMP-1 was discovered in Pseudomonas aeruginosa GN17203 in 1988, and blaIMP-1 has since been detected in other bacteria, including Enterobacterales. Currently, many varian...
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa [0.03%]
外排泵抑制剂，苯丙氨酸-精氨酰β-萘胺类似物可增强5-O-甲氨基酪醇对多重耐药铜绿假单胞菌的活性
Aoi Kimishima,Masako Honsho,Junsei Terai et al.
Aoi Kimishima et al.
The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is responsible for a substantial proportion of this global health issue because of its intrinsic resistance to many antibiotics ...
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292 [0.03%]
新抗疟疾药物iromycin类似物由链霉菌RBL-0292产生
So-Ichiro Kimura,Yoshihiro Watanabe,Shiori Shibasaki et al.
So-Ichiro Kimura et al.
Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured material of Streptomyces sp. RBL-0292 isolated from the soil on Hamahiga Island in Okinawa prefecture. The structures of 1...
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria [0.03%]
氟喹诺酮类抗菌药DC-159a对分枝杆菌的体外和离体活性研究
Belén R Imperiale,María B Mancino,Roberto D Moyano et al.
Belén R Imperiale et al.
Antimicrobial resistance is a global health problem. In 2021, it was estimated almost half a million of multidrug-resistant tuberculosis (MDR-TB) cases. Besides, non-tuberculous mycobacteria (NTM) are highly resistant to several drugs and t...
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds [0.03%]
携带多个生物合成基因簇产生多种化合物的大型细菌人工染色体克隆的能力
Kei Kudo,Takehiro Nishimura,Miho Izumikawa et al.
Kei Kudo et al.
The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized because the polyketide synthases that generate the polyketide chains of the basic backbone are of very high molecular wei...
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors [0.03%]
恶性肿瘤儿童尿路病原E.coli ST131的生物膜形成及耐药性研究
Noha Anwar Hassuna,Eman M Rabea,W K M Mahdi et al.
Noha Anwar Hassuna et al.
The multidrug-resistant clone identified as Escherichia coli sequence type 131 (E. coli ST131) has spread world-wide. This study sought to ascertain the frequency and biofilm formation of E. coli ST131 isolated from children with various ma...
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699 [0.03%]
Amycolatopsis mediterranei S699后PKS修饰基因敲除突变体中的前安莎霉素B衍生物
Xinyu Ma,Feng Ye,Xiaochun Zhang et al.
Xinyu Ma et al.
Ten new proansamycin B congeners (1-10) together with one known (11) were isolated and characterized on the basis of 1D and 2D NMR spectroscopic and HRESIMS data from the Amycolatopsis mediterranei S699 ΔPM::rifR+rif-orf19 mutant. Compound...
Actinobacterial chalkophores: the biosynthesis of hazimycins [0.03%]
放线菌(chalkophores)：Hazimycin的生物合成
Kenichi Matsuda,Hiroto Maruyama,Kumiko Imachi et al.
Kenichi Matsuda et al.
Copper is a transition metal element with significant effects on the morphological development and secondary metabolism of actinobacteria. In some microorganisms, copper-binding natural products are employed to modulate copper homeostasis, ...