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The Journal of antibiotics. 2024 Jun;77(6):345-352. doi: 10.1038/s41429-024-00714-6 Q22.72025

Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study

脯氨酰拉帕霉素的结构:通过修订和详细的NMR指认研究予以确认 翻译改进

Annalisa Mortoni  1, Eugenio Castelli  2, Teresa Recca  3, Paolo Quadrelli  4

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作者单位

  • 1 Curia Italy S.r.l., Via Volturno 43, 20089, Rozzano, MI, Italy. annalisa.mortoni@curiaglobal.com.
  • 2 Curia Italy S.r.l., Via Volturno 43, 20089, Rozzano, MI, Italy.
  • 3 Centro Grandi Strumenti (CGS), Università degli Studi di Pavia, Via Bassi 21, 27100, Pavia, Italy.
  • 4 Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100, Pavia, Italy. paolo.quadrelli@unipv.it.
  • DOI: 10.1038/s41429-024-00714-6 PMID: 38504121

    摘要 Ai翻译

    A complete and detailed characterization of Rapamycin (1) and Prolylrapamycin (2) has been conducted by homo- and hetero-nuclear NMR experiments in DMSO-d6 along with HRMS and FT-IR spectra and DSCs analyses. The NMR experiments allowed the assignment of every single proton and carbon atom belonging to the two structures and the definitive confirm of the presence of a pyrrolidine ring in Prolylrapamycin (2) in place of the piperidine ring that characterize... ...点击完成人机验证后继续浏览
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    期刊名:Journal of antibiotics

    缩写:J ANTIBIOT

    ISSN:0021-8820

    e-ISSN:1881-1469

    IF/分区:2.7/Q2

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    Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study