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The Journal of antibiotics. 2024 May;77(5):288-298. doi: 10.1038/s41429-024-00711-9 Q22.72025

Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds

携带多个生物合成基因簇产生多种化合物的大型细菌人工染色体克隆的能力 翻译改进

Kei Kudo  1, Takehiro Nishimura  2  3, Miho Izumikawa  4, Ikuko Kozone  4, Junko Hashimoto  4, Manabu Fujie  5, Hikaru Suenaga  1, Haruo Ikeda  6  2, Nori Satoh  5, Kazuo Shin-Ya  7  8

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作者单位

  • 1 Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan.
  • 2 Technology Research Association for Next Generation Natural Products Chemistry, 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan.
  • 3 Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
  • 4 Japan Biological Informatics Consortium (JBIC), 2-4-32 Aomi, Koto-ku, Tokyo, 135-0064, Japan.
  • 5 Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0495, Japan.
  • 6 Kitasato Institute for Life Sciences, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
  • 7 Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan. k-shinya@aist.go.jp.
  • 8 Technology Research Association for Next Generation Natural Products Chemistry, 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan. k-shinya@aist.go.jp.

    • DOI: 10.1038/s41429-024-00711-9 PMID: 38438499

    摘要 Ai翻译

    The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized because the polyketide synthases that generate the polyketide chains of the basic backbone are of very high molecular weight. In developing a heterologous expression system for the large BGCs amenable to the production of such natural products, we selected concanamycin as an appropriate target. We obtained a bacterial artificial chromosome... ...点击完成人机验证后继续浏览
    Copyright © The Journal of antibiotics. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Journal of antibiotics

    缩写：J ANTIBIOT

    ISSN：0021-8820

    e-ISSN：1881-1469

    IF/分区：2.7/Q2

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    Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds