The Journal of antibiotics. 2024 Apr;77(4):228-237. doi: 10.1038/s41429-024-00706-6 Q22.72025
Actinobacterial chalkophores: the biosynthesis of hazimycins
放线菌(chalkophores)：Hazimycin的生物合成 翻译改进
Kenichi Matsuda 1, Hiroto Maruyama 2, Kumiko Imachi 2, Haruo Ikeda 3, Toshiyuki Wakimoto 4
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作者单位
1 Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan. kematsuda@pharm.hokudai.ac.jp.2 Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan.3 Technology Research Association for Next generation natural products chemistry, 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan.4 Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan. wakimoto@pharm.hokudai.ac.jp.
DOI: 10.1038/s41429-024-00706-6 PMID: 38378905
摘要 Ai翻译
Copper is a transition metal element with significant effects on the morphological development and secondary metabolism of actinobacteria. In some microorganisms, copper-binding natural products are employed to modulate copper homeostasis, although their significance in actinobacteria remains largely unknown. Here, we identified the biosynthetic genes of the diisocyanide natural product hazimycin in Kitasatospora purpeofusca HV058, through gene knock-out a... ...点击完成人机验证后继续浏览
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