Shielding retinal pigment epithelium cells from high glucose-induced oxidative stress: the protective effect of phospholipase D (PLD) pathway inhibition [0.03%]
磷脂酶D信号通路抑制对高糖诱导色素上皮细胞氧化应激的保护作用研究
María S Echevarría,Paula E Tenconi,Vicente Bermúdez et al.
María S Echevarría et al.
The retinal pigment epithelium (RPE) performs key roles in preserving retinal integrity and must continuously manage oxidative stress (OS). We previously demonstrated that the canonical phospholipase D isoforms, PLD1 and PLD2, mediate the R...
The endocytic fission protein EHD1 interacts with tubulin and regulates microtubule function [0.03%]
内吞分裂蛋白EHD1与微管蛋白相互作用并调节微管功能
Bazella Ashraf,Journey Reddick-Umoja,Jasmyn Grant et al.
Bazella Ashraf et al.
The Eps15 Homology Domain protein-1 (EHD1) is an ATPase and key endocytic regulatory protein required for optimal receptor recycling, and primary ciliogenesis. Over the past decade, a central role for EHD1 has been identified in the fission...
Destabilization of lipoma-preferred partner by TGF-β-induced O-GlcNAcylation promotes hepatocellular carcinoma metastasis [0.03%]
TGF-β通过O-GlcNA酰化使肝细胞癌转移促进因子LPP失稳定
De-Ao Gong,Qin Yang,Yan-Lai Zhang et al.
De-Ao Gong et al.
Metastatic dissemination drives the lethal progression of hepatocellular carcinoma (HCC). A comprehensive elucidation of the post-translational modifications involved in this process is anticipated to facilitate the development of more effe...
The dual face of reprogrammed proteostasis in cancer and its epigenetic regulation: A survival option and a therapeutic opportunity [0.03%]
重编程蛋白质稳态在癌症中的双重作用及其表观遗传调控：一种生存选择和治疗机会
Mara Cirone
Mara Cirone
Proteostasis is essential for cellular homeostasis and is maintained through an integrated network encompassing the unfolded protein response (UPR), molecular chaperones such as heat shock proteins (HSPs), and degradative systems including ...
The role of cytokines in cytokine release syndrome (CRS) after CAR T cell therapy [0.03%]
细胞因子在CAR-T治疗后细胞因子释放综合征(CRS)中的作用
Kathrin Gabriel,Lucie Heinzerling,Louisa von Baumgarten et al.
Kathrin Gabriel et al.
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape for hematological malignancies. However, cytokine release syndrome (CRS) remains a common and potentially severe toxicity, significantly affecting patien...
The language of cytokines: Decoding immune signals with information theory [0.03%]
细胞因子的语言：用信息理论解码免疫信号
Sophie Streuber,Emelie Rieneck,Fred Schaper et al.
Sophie Streuber et al.
Communication between cells is fundamental for maintaining and restoring homeostasis in multicellular organisms under both physiological and pathological conditions. A variety of mechanisms for encoding, transmitting, and decoding informati...
Sox9-dependent acquisition of a drug resistant "memory state" induces reciprocal expression of Sox6 and Sox7 in BRAF melanoma [0.03%]
SOX9依赖性的药物抵抗性“记忆状态”的获得诱导黑色素瘤中SOX6和SOX7的互斥表达
John Abou-Hamad,Samuel Delisle,Brennan Garland et al.
John Abou-Hamad et al.
In melanoma, SOX9 and SOX10 are markers of the mesenchymal and melanocytic state, respectively. Using a panel of BRAFV600E positive YUMM lines, we find that, following chronic vemurafenib treatment, SOX10 is lost whereas SOX9 is induced. Ov...
Friend or foe: New cytokine players in beta cell failure in type 1 diabetes mellitus [0.03%]
敌友难辨：1型糖尿病发病中β细胞功能衰竭的新细胞因子参与因素
Ewa Gurgul-Convey,Ortwin Naujok
Ewa Gurgul-Convey
Cytokines play a crucial role in autoimmune-mediated loss of pancreatic beta cells during type 1 diabetes (T1DM) development. The main diabetogenic cytokines IL-1β, TNFα and IFNγ, which were found to be profoundly upregulated in serum of...
Cyclin dependent kinases CDK8/19 are required for PKA inactivation during meiosis resumption [0.03%]
细胞周期素依赖性激酶CDK8/19是介导减数分裂恢复过程中PKA失活所必需的
D Yulia Okulova,A Maxim Filatov,A Ekaterina Varlamova et al.
D Yulia Okulova et al.
CDK8/19 are transcriptional cyclin dependent kinases, which do not directly control cell cycle progression. CDK8/19 are involved in regulation of multiple processes in embryogenesis, cancer progression, immune activation and others. Previou...
ADAM10 and ADAM17 differently mediate induced pulmonary ACE release by either direct proteolysis or indirect upregulation protein synthesis [0.03%]
ADAM10和ADAM17通过直接蛋白水解或间接上调蛋白质合成介导诱导的肺ACE释放
Yan Yu,Aaron Babendreyer,Alessa Pabst et al.
Yan Yu et al.
Angiotensin-converting enzyme (ACE) is expressed on lung endothelium and can promote hypertension and cardiovascular diseases. By the activity of the metalloproteinase ADAM10 ACE can be constitutively released from the cell membrane as solu...