LAPTM4B promotes gefitinib resistance and tumor stemness in non-small cell lung cancer by stabilizing RPS3 through inhibiting its ubiquitination [0.03%]
LAPTM4B通过抑制RPS3的泛素化来稳定RPS3，从而促进非小细胞肺癌中吉非替尼耐药和肿瘤干细胞特性
Yu Jiang,Wen-Jing Xie,Rong-Wei Chen et al.
Yu Jiang et al.
Gefitinib resistance remains a major obstacle to the effective treatment of non-small cell lung cancer (NSCLC), and the underlying molecular mechanisms have not yet been fully elucidated. Lysosomal-associated transmembrane protein 4B (LAPTM...
Putative gatekeepers of incoming DNA: 3' exonucleases in natural transformation and bacterial evolution [0.03%]
入胞DNA的潜在看护者：自然转化和细菌进化中的3'外切核酸酶
Rebecca Hinrichs
Rebecca Hinrichs
Natural transformation is a key mechanism of bacterial adaptation in which exogenous DNA (eDNA) is taken up, processed into single-stranded DNA (ssDNA), and integrated into the genome. While earlier studies primarily focused on uptake mecha...
Mitochondrial RNA polyadenylation: Defining RNA fate through 3' end regulation [0.03%]
线粒体RNA多聚腺苷酸化：通过3′末端调控定义RNA的命运
Linden Muellner-Wong,William Carter,Christoph Freyer et al.
Linden Muellner-Wong et al.
Polyadenylation is a conserved post-transcriptional RNA modification with fundamentally different consequences for RNA fate across biological systems. In bacteria, chloroplasts, and plant mitochondria, adenylation is generally associated wi...
Christoph Garbers
Christoph Garbers
Metabolism alterations accompany the invasive phenotype of melanoma cells resistant to BRAF/MEK inhibitors [0.03%]
BRAF/MEK抑制剂耐药的黑色素瘤细胞侵袭表型的变化伴随着代谢的改变
Magdalena Kot,Aleksandra Simiczyjew,Katarzyna Pietraszek-Gremplewicz et al.
Magdalena Kot et al.
Mutations in the BRAF (B-raf serine-threonine-protein kinase) gene occur in the majority of melanoma patients and significantly contribute to the progression of the disease. One of the most commonly used methods for treating melanoma is the...
TRIM31 regulates neutrophilic asthma by suppressing IL-17 pathway through decreasing the M1-linked ubiquitination of TRAF6 [0.03%]
TRIM31通过减少TRAF6的M1连接泛素化来抑制IL-17通路从而调控中性粒细胞哮喘
Yuchun Liu,Lifeng Li,Chengbo Wang et al.
Yuchun Liu et al.
Neutrophilic asthma is defined as an inflammatory disease typified by airway neutrophil infiltration. Tripartite motif-containing protein 31 (TRIM31), an E3 ligase, is implicated in various processes, including inflammation, tumorigenesis, ...
The EPAC inhibitor ESI-09 attenuates NF-κB signalling in vascular cells [0.03%]
EPAC抑制剂ESI-09减轻血管细胞的NF-κB信号转导作用
Jolanta Wiejak,Frederick G Powell,Paul Burgoyne et al.
Jolanta Wiejak et al.
Vascular smooth muscle cells (VSMCs) and human coronary artery endothelial cells (HCAECs) are central mediators of vascular inflammation through NF-κB-dependent transcriptional responses, but the role of the cAMP effector exchange protein ...
The ubiquitin-activating enzyme inhibitor TAK-243 activates store-operated Ca2+ channels independently of endoplasmic reticulum Ca2+ stores and enhances mitochondrial Ca2+ buffering capacity in DU-145 human prostate cancer cells [0.03%]
泛素激活酶抑制剂TAK-243在人前列腺癌DU-145细胞中独立于内质网Ca2+库而激活储钙池操作型Ca2+通道并增强线粒体Ca2+蓄积能力
Marie Perrier,J Cory Benson,Marie-Odile Fauvarque et al.
Marie Perrier et al.
TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1, impairs the ubiquitination of proteins. We investigated its effects on the intracellular Ca2+ dynamics of human prostate cancer cells DU-145. Live-cell Ca2+ imaging with Fura2 s...
Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina [0.03%]
Kinesin-3和货物适配器Hook1调节早期胞内体和过氧化物酶体的运动，对于Podospora anserina中极性真菌细胞生长过程中的线粒体和内质网的空间组织是必需的
Fernando Hernández-Sánchez,Yovanna A Pardo-Fermín,Sara Schroder et al.
Fernando Hernández-Sánchez et al.
Microtubule-based organelle transport is essential for organelle positioning within cells and defines the architecture and function of highly polarized cells, like animal neurons and fungal hyphae. Early endosome transport depends on kinesi...
The emerging role of iRhom pseudoproteases in cytokine biology, inflammation and cancer [0.03%]
iRhom伪酶在细胞因子生物学、炎症和癌症中的新兴作用
Shermin Chan,Rhynelle Dmello,Mohamed I Saad
Shermin Chan
The family of inactive rhomboid-like proteins (iRhoms) have emerged as essential non-catalytic modulators of membrane protein trafficking and signaling, particularly in inflammation, and cancer, through their selective regulation of the pro...