Christoph Garbers
Christoph Garbers
Metabolism alterations accompany the invasive phenotype of melanoma cells resistant to BRAF/MEK inhibitors [0.03%]
BRAF/MEK抑制剂耐药的黑色素瘤细胞侵袭表型的变化伴随着代谢的改变
Magdalena Kot,Aleksandra Simiczyjew,Katarzyna Pietraszek-Gremplewicz et al.
Magdalena Kot et al.
Mutations in the BRAF (B-raf serine-threonine-protein kinase) gene occur in the majority of melanoma patients and significantly contribute to the progression of the disease. One of the most commonly used methods for treating melanoma is the...
TRIM31 regulates neutrophilic asthma by suppressing IL-17 pathway through decreasing the M1-linked ubiquitination of TRAF6 [0.03%]
TRIM31通过减少TRAF6的M1连接泛素化来抑制IL-17通路从而调控中性粒细胞哮喘
Yuchun Liu,Lifeng Li,Chengbo Wang et al.
Yuchun Liu et al.
Neutrophilic asthma is defined as an inflammatory disease typified by airway neutrophil infiltration. Tripartite motif-containing protein 31 (TRIM31), an E3 ligase, is implicated in various processes, including inflammation, tumorigenesis, ...
The EPAC inhibitor ESI-09 attenuates NF-κB signalling in vascular cells [0.03%]
EPAC抑制剂ESI-09减轻血管细胞的NF-κB信号转导作用
Jolanta Wiejak,Frederick G Powell,Paul Burgoyne et al.
Jolanta Wiejak et al.
Vascular smooth muscle cells (VSMCs) and human coronary artery endothelial cells (HCAECs) are central mediators of vascular inflammation through NF-κB-dependent transcriptional responses, but the role of the cAMP effector exchange protein ...
The ubiquitin-activating enzyme inhibitor TAK-243 activates store-operated Ca2+ channels independently of endoplasmic reticulum Ca2+ stores and enhances mitochondrial Ca2+ buffering capacity in DU-145 human prostate cancer cells [0.03%]
泛素激活酶抑制剂TAK-243在人前列腺癌DU-145细胞中独立于内质网Ca2+库而激活储钙池操作型Ca2+通道并增强线粒体Ca2+蓄积能力
Marie Perrier,J Cory Benson,Marie-Odile Fauvarque et al.
Marie Perrier et al.
TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1, impairs the ubiquitination of proteins. We investigated its effects on the intracellular Ca2+ dynamics of human prostate cancer cells DU-145. Live-cell Ca2+ imaging with Fura2 s...
Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina [0.03%]
Kinesin-3和货物适配器Hook1调节早期胞内体和过氧化物酶体的运动，对于Podospora anserina中极性真菌细胞生长过程中的线粒体和内质网的空间组织是必需的
Fernando Hernández-Sánchez,Yovanna A Pardo-Fermín,Sara Schroder et al.
Fernando Hernández-Sánchez et al.
Microtubule-based organelle transport is essential for organelle positioning within cells and defines the architecture and function of highly polarized cells, like animal neurons and fungal hyphae. Early endosome transport depends on kinesi...
The emerging role of iRhom pseudoproteases in cytokine biology, inflammation and cancer [0.03%]
iRhom伪酶在细胞因子生物学、炎症和癌症中的新兴作用
Shermin Chan,Rhynelle Dmello,Mohamed I Saad
Shermin Chan
The family of inactive rhomboid-like proteins (iRhoms) have emerged as essential non-catalytic modulators of membrane protein trafficking and signaling, particularly in inflammation, and cancer, through their selective regulation of the pro...
Sensing the needs: Molecular basis of miRNA regulatory role of ELAVL protein HuR [0.03%]
感应需求：ELAVL蛋白HuR调控作用的miRNA分子基础
Kamalika Mukherjee
Kamalika Mukherjee
Regulation of miRNAs in mammalian cells-including their expression, activity, transport, storage, and export-is vital for the control of gene expression and cellular function. This process is affected by external stimuli, such as stress or ...
IL-6 family cytokines behind acute COVID-19 and Long COVID syndrome: Mechanisms, biomarkers, and intervention strategies [0.03%]
急性COVID-19和长新冠综合征背后的IL-6家族细胞因子：机制、生物标志物和干预策略
Matilde Bustos,María Ángeles Rodríguez-Hernández
Matilde Bustos
IL-6 family of cytokines is increasingly recognized as a potential contributor to the immune alterations observed in COVID-19 and its long-term sequelae. Beyond the well-established pro-inflammatory actions of IL-6 itself, members of this f...
RSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy [0.03%]
RSL1D1缺乏通过降低FTH1稳定性诱导糖尿病视网膜病变中色素上皮细胞的铁死亡和衰老现象
Leilei Qin,Yanli Guo,Yi Zhang et al.
Leilei Qin et al.
Ribosomal L1 domain-containing protein 1 (RSL1D1) is an RNA-binding protein that relates to senescence. Nevertheless, the mechanism of RSL1D1 in modulating senescence and ferroptosis in diabetic retinopathy (DR) remains undefined. The DR mi...