Endoplasmic reticulum stress-mediated epithelial-mesenchymal transition contributes to cardiac biomarker-induced kidney injury [0.03%]
内质网应激介导的上皮间质转化加重心脏生物标志物所致肾损伤
Mengyuan Cheng,Xiaoyu Zhang,Ye Shi et al.
Mengyuan Cheng et al.
Renal dysfunction is a frequent comorbidity in heart failure (HF) patients, independently linked to poor prognosis. However, the intricate pathogenesis of the complex interaction between the heart and kidney remains unclear. This study anal...
Activation of phosphoenolpyruvate carboxykinase increases intracellular glucose levels in podocytes under hyperglycemic conditions [0.03%]
磷烯醇式丙酮酸羧基酶的激活可增加高糖条件下足细胞内的葡萄糖水平
Karol Zakrzewski,Olga Żołnierkiewicz,Patrycja Rachubik et al.
Karol Zakrzewski et al.
Gluconeogenesis (GNG) is a process of glucose synthesis from non-carbohydrate precursors, which is enhanced in diabetic kidneys, contributing to elevations of blood glucose. Podocytes mainly utilize glucose to maintain glomerular filtration...
Thymic stromal lymphopoietin (TSLP) - pro-inflammatory cytokine and antimicrobial peptide [0.03%]
胸腺基质淋巴细胞生成素(TSLP)-促炎症细胞因子和抗菌肽
Katinka Döhner,Ojonugwa Precious John,Thomas Werfel
Katinka Döhner
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine primarily produced by epithelial cells. It functions as a key regulator of immune responses, especially at barrier surfaces such as the skin, gut, and respiratory tract. Humans e...
JAK1/STAT3 signalling in cortical bone development, growth and maintenance [0.03%]
JAK1/STAT3信号转导在皮质骨的发育、生长和维持中的作用
Natalie Y Y Koh,Christa Maes,Natalie A Sims
Natalie Y Y Koh
STAT3 (Signal Transducer and Activator of Transcription 3) signalling plays essential roles in the development, growth, and maintenance of the thick outer structure of bone (cortical bone). Cytokines using this pathway, particularly IL-6 (I...
Molecular regulation of common γ-chain / Interleukin-2 family cytokine receptors [0.03%]
共同γ链/白细胞介素-2家族细胞因子受体的分子调控
Katharina Moerk,Juliane Lokau
Katharina Moerk
Cytokines are small secreted proteins that mediate intercellular communication. Among numerous cytokines, members of the common γ-chain (γc) family have emerged as key regulators of immune responses. This family consists of Interleukin-2 ...
Distinct and context-dependent immunobiology of interleukin (IL)-36, IL-37, and IL-38: A comparative review [0.03%]
白细胞介素(IL)-36、IL-37 和 IL-38 的独特且上下文依赖的免疫生物学：综述性比较研究
Farshad Niazpour,Lars P Lunding,Ina Rudloff et al.
Farshad Niazpour et al.
Interleukin (IL)-36, IL-37, and IL-38 belong to the newer members of the IL-1 cytokine family that exert diverse and context-dependent immune functions. IL-36α/β/γ are predominantly pro-inflammatory cytokines, whereas IL-37 and IL-38 fun...
Neutrophil-mediated modulation of tumor angiogenesis: From proangiogenic mediators to extracellular vesicles [0.03%]
中性粒细胞介导的肿瘤血管生成调控：从促血管生成介质到细胞外囊泡
Weronika Jurczyk,Jadwiga Jablonska,Mateusz Smolarz
Weronika Jurczyk
Angiogenesis is a tightly controlled physiological process that enables the formation of new blood vessels. Under normal conditions, it is regulated by a balance between pro- and anti-angiogenic signals. In cancer, this equilibrium is disru...
Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines [0.03%]
差异包含形成易聚集蛋白揭示神经细胞系中蛋白质稳态能力的差异
Shannon McMahon,Dezerae Cox,Flora Cheng et al.
Shannon McMahon et al.
Maintaining proteome integrity is essential for cellular function and survival. Disruptions in proteostasis lead to the aggregation of proteins into inclusions, a process that underlies many neurodegenerative diseases. To quantitatively ass...
FBXO32 activates the PI3K/AKT pathway by inhibiting PTEN through ubiquitination of TAL1 in hepatocellular carcinoma [0.03%]
FBXO32通过泛素化TAL1抑制PTEN从而激活PI3K / AKT通路以促进肝细胞癌的发展
Yujie Xiong,Xuefeng Yang,Ting Cao
Yujie Xiong
The role of E3 ubiquitin ligases in cellular mechanisms and cancer progression is critical. In this study, our primary objective was to elucidate the functional consequences of F-box only protein 32 (FBXO32) in the progression and metastasi...
Insights into the regulation and signaling landscape of cardiotrophin-like cytokine factor 1 (CLCF1) [0.03%]
卡软素类似细胞因子因素1（CLCF1）的调控和信号网络研究新进展
Marine Rousseau,France Côté,Sylvain Chemtob et al.
Marine Rousseau et al.
Cardiotrophin-like cytokine factor 1 (CLCF1) is an essential gene that shows exceptional sequence conservation among vertebrates. CLCF1 loss-of-function mutations cause Crisponi/cold-induced sweating syndrome-2, a disorder with severe and c...