Adhesion GPCR ADGRL1/Latrophilin-1 mobilizes β-arrestins as a prerequisite for endosomal restriction of G protein activation and splice-dependent scaffolds
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Sustained signaling mediated by β-arrestins (βarr) in endosomal compartments has been described for several classical G protein-coupled receptors (GPCR), yet whether adhesion GPCRs-many of which exhibit constitutive activity driven by intrinsic agonism-engag... ...