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DUSP4 mitigates doxorubicin-induced cardiotoxicity via the p38 MAPK/MK2 signaling pathway

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Doxorubicin (DOX) is a potent chemotherapeutic agent widely used to treat various malignancies; however, its dose-dependent cardiotoxicity severely limits long-term clinical application. Loss of Dual Specificity Phosphatase 4 (DUSP4) has been reported in multi... ...