SFRP2 is involved in hyperoxia-induced bronchopulmonary dysplasia in newborn mice by suppressing Nrf2/HO-1 pathway [0.03%]
SFRP2通过抑制Nrf2/HO-1信号通路参与新生小鼠高氧诱导性支气管肺发育不良
Jingjing Li,Xiaoxia Feng,Ranran Si et al.
Jingjing Li et al.
Bronchopulmonary dysplasia (BPD), characterized by inflammation, is a severe pulmonary condition of preterm infants. This study aimed to investigate the role of secreted frizzled related protein 2 (SFRP2) in BPD and to elucidated its underl...
USP1 represses ferroptosis in endometrial carcinoma cells by regulating the ubiquitination and stability of ESR1 [0.03%]
USP1通过调节ESR1的泛素化和稳定性抑制子宫内膜癌细胞的铁死亡
Qiaoyan Lin,Yanping Xiao,Jiuyue Liu et al.
Qiaoyan Lin et al.
Endometrial carcinoma (EC) is a prevalent gynecologic malignancy. Ferroptosis, a type of programmed cell death, holds promise as a therapeutic strategy for cancer treatment. However, the specific role of ferroptosis and the underlying mecha...
New insights into the multifaceted role of eryptosis in metabolic and cardiovascular diseases [0.03%]
eryptosis在代谢及心血管疾病中作用的新见解
Anton Tkachenko,Martha A Quintanar-Escorza,Liliya Tryfonyuk et al.
Anton Tkachenko et al.
Cardiovascular diseases (CVDs) remain a global medical and social burden with high morbidity and mortality rates worldwide. CVDs are strongly linked to thrombosis, anemia, endothelial dysfunction, or inflammation. A growing body of evidence...
USP8/GPX4-based live-cell quantitative FRET imaging for ferroptosis drug screening [0.03%]
基于USP8/GPX4的活细胞FRET成像技术用于铁死亡药物筛选研究
Xinghong Cai,Ziru Wu,Zhiyu Xiao et al.
Xinghong Cai et al.
Targeting the functional interface between USP8 and GPX4 to disrupt ferroptosis defense represents a novel therapeutic strategy in cancer. Currently, there is a lack of drug screening models targeting the USP8/GPX4 interaction. This study u...
Mammalian mtDNA gene expression: Concepts learned from in vivo models [0.03%]
哺乳动物线粒体基因表达：从体内模型中学到的概念
Diana Rubalcava-Gracia,Nils-Göran Larsson
Diana Rubalcava-Gracia
Mammalian mitochondrial DNA (mtDNA) expression is essential for oxidative phosphorylation (OXPHOS) and its in vivo regulation requires significant refinement. Here, we review key insights from mouse models carrying genetic modifications to ...
Coordinated regulation of cell differentiation by sphingosine-1-phosphate receptors in renal epithelial cells [0.03%]
鞘氨醇-1-磷酸受体在肾上皮细胞分化中的协同调节作用
Daniela Judith Romero,Lucila Gisele Pescio,Germán Loiacono et al.
Daniela Judith Romero et al.
Sphingolipids regulate essential cellular processes, with sphingosine-1-phosphate (S1P) emerging as a critical modulator of proliferation, migration, and differentiation. While intracellular S1P governs sphingolipid metabolism during renal ...
Unveiling NDRGs as potential modulators of insulin signaling and insulin resistance in the central nervous system [0.03%]
揭示NDRG作为中枢神经系统中胰岛素信号和胰岛素抵抗的潜在调节因子
Atreyi Mukherjee,Chinmoy Sankar Dey
Atreyi Mukherjee
The N-myc downstream-regulated gene (NDRG) family comprises four proteins (NDRG1-4) that lack intrinsic catalytic activity and participate in diverse cellular processes, including differentiation, stress responses, and metabolic regulation....
The dual role of heat shock protein 60 in Cardiac diseases: From mitochondrial chaperone to extracellular immunomodulator - A review and future perspectives [0.03%]
热休克蛋白60在心脏疾病中的双重作用：从线粒体分子伴侣到细胞外免疫调节因子-综述与未来展望
Vahid Saqagandomabadi,Adelaide Carista,Stefano Burgio et al.
Vahid Saqagandomabadi et al.
The abundance of mitochondria in cardiac cells is vital, as they are extremely important for adenosine triphosphate (ATP) synthesis, maintaining redox balance, regulating calcium homeostasis, and facilitating lipid synthesis. One of the mos...
Corrigendum to "Thermotolerance induced at a mild temperature of 40 °C alleviates heat shock-induced ER stress and apoptosis in HeLa cells" [Biochim. Biophys. Acta - Mol. Cell Res. 1853 (2015) 52-62/PMID: 25260982] [0.03%]
“40°C低热处理诱导的热耐受减轻了热休克引起的内质网应激和HeLa细胞凋亡[BBA-分子细胞生物学研究][Biochim.Biophys.Acta-Mol.Cell.Biol.]的勘误[2015,Vol.1853,Iss.1,PP.52-62/Pmid:25260982]”校正表
Ahmed Bettaieb,Diana A Averill-Bates
Ahmed Bettaieb
LMCD1 aggravates cardiac fibrosis after myocardial infarction via activating STAT5A [0.03%]
LMCD1通过激活STAT5A加重心肌梗死后的心脏纤维化
Haofei Kang,Jing Liu,Junjie Wang et al.
Haofei Kang et al.
Cardiac fibrosis, a maladaptive remodeling process following myocardial infarction (MI), is a key driver of heart failure, the precise molecular regulators governing cardiac fibroblast activation remain incompletely understood. LIM and cyst...