Extracellular matrix stiffness primes the NLRP-inflammasome by promoting NLRP3 gene expression via FAK/mTOR/nuclear-actin/SREBP signalling in vascular smooth muscle cells
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Arterial stiffening is associated with an increased risk of cardiovascular disease (CVD) morbidity and mortality. We investigated the effects of ECM-stiffness on the expression of NLRP3, a component of the NLRP3-inflammasome. VSMC interacting with a stiff (50 ... ...
