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Mupirocin-mediated downregulation of claudin-14 enhances chemosensitivity in human colorectal cancer cells

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Claudin-14 (CLDN14), a tight junction protein, contributes to cell proliferation and chemoresistance in human colorectal cancer (CRC)-derived DLD-1 cells. However, small molecules targeting CLDN14 remain unexplored. Here, we identified mupirocin (MUP), a clini... ...