TGF-β-YY1 signaling as a key driver of immune evasion in pancreatic cancer: Therapeutic implications [0.03%]
转化生长因子-β-YY1信号通路在胰腺癌免疫逃逸中的关键作用及治疗意义
Mai P Ho,Megan Jung,William Ung et al.
Mai P Ho et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by a dense desmoplastic stroma, profound immune suppression, and resistance to conventional therapeutics. Poor patient outcomes are driven by resistance to ...
GDF15 in the tumor microenvironment: A central mediator of cancer immunometabolism and therapeutic resistance [0.03%]
肿瘤微环境中的GDF15：癌症免疫代谢和治疗抵抗的关键调解因素
Lingeng Lu,Caroline H Johnson,Sajid A Khan et al.
Lingeng Lu et al.
Growth differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β (TGFβ) superfamily, has emerged as a pivotal cytokine linking cancer metabolism, immune suppression, and systemic energy balance. Initially c...
Reprogramming immunity at the metabolic-epidermal interface in obesity-associated psoriasis [0.03%]
肥胖相关银屑病代谢-表皮界面免疫重塑
Jinsun Jang,Minji Park,Hee Joo Kim et al.
Jinsun Jang et al.
Obesity and psoriasis are chronic inflammatory disorders, now recognized to be interconnected, in which metabolic overload drives immune dysregulation and therapeutic resistance. Excess adiposity converts adipose tissue into an inflammatory...
cPLA2 in musculoskeletal and autoimmune diseases: Molecular mechanisms and therapeutic insights [0.03%]
肌肉骨骼及自身免疫病中的cPLA2：分子机制和治疗启示
Chaopeng He,Guiwu Huang,Jingwei Bi et al.
Chaopeng He et al.
Cytosolic phospholipase A2 (cPLA2) is a central regulator of lipid signaling that links cytokine and growth factor signaling to arachidonic acid metabolism and downstream eicosanoid production. Dysregulated cPLA2 activity is increasingly re...
Cytokine associated neuroinflammation in Parkinson's disease: Molecular pathways, therapeutic targets, and translational insights [0.03%]
帕金森病相关的细胞因子介导的神经炎症：分子通路、治疗靶点和转化见解
Rishika Dhapola,Sneha Kumari,Prajjwal Sharma et al.
Rishika Dhapola et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which neuroinflammation plays a key role. An imbalance between pro- and anti-inflammatory cytokines has been observed in both experimental models and PD patients. The i...
Bacterial immunomodulatory structures as determinants of the maternal immune response and autism risk [0.03%]
细菌免疫调节结构在母体免疫反应和自闭症风险中的作用因子
Isaac S B Russell,Melissa L Perreault
Isaac S B Russell
Autism is a group of neurodevelopmental conditions that have shown increasing prevalence over the last several decades. Despite being largely idiopathic in origin, numerous genetic and environmental risk factors have been identified. One of...
Missing the pattern: Pathogenic structural considerations in the maternal immune signature and autism risk [0.03%]
错失的模式：母体免疫信号特征中的致病结构及自闭症发病风险
Isaac S B Russell,Melissa L Perreault
Isaac S B Russell
Maria Victoria Souto-Silva,Elizabete Cristina Iseke Bispo,Nakaly Natiely de Oliveira et al.
Maria Victoria Souto-Silva et al.
The skin barrier functions as both a structural defense and an immunological interface that integrates environmental, microbial, and systemic signals. Its disruption predisposes to cutaneous inflammation and contributes to systemic immune d...
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers [0.03%]
紧密绑定的T细胞簇：一类超效应肿瘤杀手的新分类
Wenxue Ma,Jessica Pham,Catriona Jamieson
Wenxue Ma
T cells have traditionally been characterized as autonomous killers that eliminate malignant cells through single-cell cytotoxicity. However, recent findings reveal that tumor-reactive T cells frequently form tightly bound clusters on the t...
Interferons as therapeutic orchestrators of cancer stem cell plasticity and therapy response [0.03%]
干扰素在癌症干细胞可塑性及治疗反应中的作用机制研究
Deepakshi Kasat,Sophia Hidalgo,Lu Wang et al.
Deepakshi Kasat et al.
Cancer stem cells (CSCs) represent a small but critical subset of tumor cells characterized by their inherent self-renewal ability, differentiation potential, and resistance to cancer therapies. Their capacity to reversibly transition betwe...