Maria Victoria Souto-Silva,Elizabete Cristina Iseke Bispo,Nakaly Natiely de Oliveira et al.
Maria Victoria Souto-Silva et al.
The skin barrier functions as both a structural defense and an immunological interface that integrates environmental, microbial, and systemic signals. Its disruption predisposes to cutaneous inflammation and contributes to systemic immune d...
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers [0.03%]
紧密绑定的T细胞簇：一类超效应肿瘤杀手的新分类
Wenxue Ma,Jessica Pham,Catriona Jamieson
Wenxue Ma
T cells have traditionally been characterized as autonomous killers that eliminate malignant cells through single-cell cytotoxicity. However, recent findings reveal that tumor-reactive T cells frequently form tightly bound clusters on the t...
Interferons as therapeutic orchestrators of cancer stem cell plasticity and therapy response [0.03%]
干扰素在癌症干细胞可塑性及治疗反应中的作用机制研究
Deepakshi Kasat,Sophia Hidalgo,Lu Wang et al.
Deepakshi Kasat et al.
Cancer stem cells (CSCs) represent a small but critical subset of tumor cells characterized by their inherent self-renewal ability, differentiation potential, and resistance to cancer therapies. Their capacity to reversibly transition betwe...
Combination therapy strategies targeting glypican-3 in hepatocellular carcinoma: A comprehensive review [0.03%]
肝癌中靶向Glypican-3的联合治疗策略：全面综述
Sina Nabiyi,Mohammad Heiat,Ehsan Rezaei
Sina Nabiyi
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide. Advanced disease often proves resistant to conventional therapies, thereby driving the intensive search for targeted therapies. Glypican-3 (GPC3),...
Dimitrios G Argyris,Lillian Johnson,Thomas Hägglöf et al.
Dimitrios G Argyris et al.
CXCL13, a chemokine originally identified for its role in B-cell trafficking, signals through the G-protein-coupled receptor CXCR5, to organize germinal centers and maintain immune architecture in secondary lymphoid organs. Beyond its physi...
Meteorin-like/Metrnl: A pleiotropic cytokine implicated in metabolic, inflammatory and malignant disorders [0.03%]
Meteorin样蛋白/Metrnl：一种参与代谢、炎症和恶性疾病的多功能细胞因子
Jinlian Li,Pei Ye,Jingli Si et al.
Jinlian Li et al.
Metrnl, a secreted protein highly expressed in adipocytes, endothelial cells, muscle cells, and activated macrophages, has been identified as a novel myokine and adipokine. It plays important roles in enhancing white fat browning, improving...
Role of anti-tumorigenic cytokines in gastrointestinal cancers [0.03%]
细胞因子在胃肠肿瘤中的抗肿瘤作用机制及临床应用前景研究进展
Olivia Hooks,Lily T Childers,Justin T Childers et al.
Olivia Hooks et al.
Gastrointestinal (GI) cancers are among the deadliest worldwide, with millions of cases and deaths annually. In the U.S., they account for over 25 % of cancer-related deaths, with colorectal cancer (CRC) leading in incidence and mortality, ...
Biological macromolecule-driven therapeutics in rheumatoid arthritis: Integrating drug delivery, regenerative medicine, and orthopedic repair [0.03%]
类风湿关节炎的生物大分子驱动疗法：药物输送、再生医学与骨科修复的整合
Jun-Ze Tang,Lin Feng,Ting-Ting Liu et al.
Jun-Ze Tang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1 % of the global population, leading to joint destruction, disability, and high socioeconomic costs. While conventional therapies like DMARDs and biologics have improv...
The IL-17 axis in gastric carcinogenesis: From inflammation to oncogenic transformation [0.03%]
胃癌发生发展中的IL-17轴：从炎症到致癌转化
Zhaojie Lyu,Mancang Gu,Zhengmao Lu et al.
Zhaojie Lyu et al.
Gastric cancer (GC) remains a leading cause of global cancer mortality, with Helicobacter pylori (Hp)-induced chronic inflammation and immune dysregulation playing a central pathogenic role. This review consolidates current understanding of...
Post COVID-19 pandemic Inflammatory Insights into Cancer: Consequences for immunotherapy [0.03%]
新冠肺炎疫情后的炎症视域与癌症免疫治疗的相互作用及影响
Carla Eksteen,Lé-Chandré Asja,Atarah Rass et al.
Carla Eksteen et al.
The COVID-19 pandemic has reshaped the landscape of global health, revealing novel interactions between infectious diseases and chronic conditions such as cancer. Beyond acute infection, growing evidence suggests that persistent exposure to...