Shared and context-specific mechanisms of T cell exhaustion in chronic viral infections and cancer: Transcriptional, metabolic, epigenetic, and therapeutic perspectives [0.03%]
慢性病毒感染和癌症中T细胞衰竭的共同机制及特定机制：转录、代谢、表观遗传及治疗观点
Wencan Zhang,Weifeng Yuan,Congli Yuan et al.
Wencan Zhang et al.
T cells are crucial for defending against viral infection and cancer by eliminating infected or transformed cells and establishing immune memory. However, persistent antigenic stimulation in chronic infections or tumors drives T cells into ...
Temporal dynamics of type I interferon signaling in checkpoint inhibitor response and resistance [0.03%]
I型干扰素信号在检查点抑制剂应答和耐药中的时相动态特征
Andrew Thake,Keith Sacco
Andrew Thake
While the long-term efficacy of checkpoint inhibition is established, the lack of response in IFN-rich tumors presents a critical challenge. These findings suggest that immune sensitivity depends on variables beyond cytokine levels and shou...
The role of osteoprotegerin in colorectal cancer: Molecular interactions, mechanistic insights, and therapeutic implications [0.03%]
骨保护素在结直肠癌中的作用：分子相互作用、机制洞察和治疗意义
Chester Yan Jie Ng,Zipan Lyu,Meng Li et al.
Chester Yan Jie Ng et al.
Background: Despite advances in emerging therapies, colorectal cancer (CRC) incidence continues to rise and clinical outcomes remain suboptimal, highlighting the need for improved management strategies. One potential ther...
Designing next-generation interleukin immunotherapy: A cytokine-guided framework for precision cancer therapy [0.03%]
下一代白细胞介素免疫疗法的设计：精准癌症治疗的细胞因子指导框架
Chunhui Wang,Wenxue Ma,Xiaohan Wang et al.
Chunhui Wang et al.
Interleukins (ILs) are powerful regulators of anti-tumor immunity, yet their clinical impact in cancer has remained limited despite decades of therapeutic development. Although first-generation cytokines such as IL-2 established proof-of-pr...
Fibroblast growth factor homologous factors in neural signaling: Molecular mechanisms and disease-relevant dysregulation [0.03%]
神经信号传导中的成纤维细胞生长因子同源因子：分子机制和与疾病相关的失调
Nanshan Song,Xiangxu Wang,Luqing Ha et al.
Nanshan Song et al.
Fibroblast growth factor homologous factors (FHFs) are the intracellular, non-secretory branch of the fibroblast growth factor (FGF) superfamily. They regulate a range of biological processes, including embryonic development, cell prolifera...
Cytokine-mediated intrinsic and extrinsic regulation of anti-tumor adoptive T cell therapy [0.03%]
细胞因子介导的针对肿瘤适应性T细胞治疗的固有和外在调节作用
Jing Hu,Jiayue Qiu,Tommy Chen et al.
Jing Hu et al.
Adoptive T cell therapy has transformed the treatment of hematologic malignancies but fails to control solid tumors, where T cell dysfunction and an immunosuppressive tumor microenvironment (TME) remain the central barriers. Cytokines are e...
Mitochondrial DNA-mediated cGAS-STING activation and its crosstalk with NLRP3 inflammasome in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病中线粒体DNA介导的cGAS-STING激活及其与NLRP3炎性小体的串扰
Disha Jindal,Vishal Chopra,Kranti Garg et al.
Disha Jindal et al.
Chronic Obstructive Pulmonary Disease (COPD) is characterised by upregulation of inflammatory mechanisms in the lungs, influenced by a variety of environmental and genetic factors. Tobacco smoke (TS) is the most prominent risk factor and on...
Role of FOXO3 in regulation of redox homeostasis and promotion of red blood cell longevity in sickle cell disease [0.03%]
FOXO3在调节氧化还原稳态和促进镰状细胞病红血球长寿中的作用
Eluri Pavitra,Meenoo Kumbhakar,Byeongsu Kim et al.
Eluri Pavitra et al.
Sickle cell disease (SCD) is a severe monogenic red blood cell (RBC) disorder that follows a simple Mendelian mode of inheritance. SCD is characterized by hemoglobin S polymerization under deoxygenated conditions, leading to chronic hemolys...
Lipid metabolic reprogramming regulates macrophage senescence in the tumor microenvironment [0.03%]
脂质代谢重组可调节肿瘤微环境中巨噬细胞的衰老现象
Yixi Liu,Chenchi Li,Jiao Wang et al.
Yixi Liu et al.
Immune checkpoint inhibitors (ICIs) have made significant progress in the treatment of many malignant tumors; however, their efficacy remains limited by the complex immune-suppressive characteristics of the tumor microenvironment (TME), wit...
Cong Xie,Yuanyuan Ma,Yunjing Wang et al.
Cong Xie et al.
Pulmonary fibrosis is the common end-stage pathological outcome of diverse interstitial lung diseases (ILDs), defined by progressive alveolar structural destruction, aberrant extracellular matrix (ECM) deposition, and ultimately fatal respi...