DRP1-mediated mitophagy facilitates oral squamous cell carcinoma tumor cell survival under glucose restriction [0.03%]
葡萄糖限制时DRP1介导的线粒体自噬促进口腔鳞状细胞癌肿瘤细胞存活
Qiuya Yu,Tao Xiao,Zixian Li et al.
Qiuya Yu et al.
Oral squamous cell carcinoma (OSCC) can progress within a nutrient-limited microenvironment, especially under low-glucose conditions. However, the mechanisms enabling tumor cells to cope with glucose limitation, particularly those that coun...
A novel role for magnetotactic bacterium: Magnetospirillum magneticum AMB-1 prolonged healthy lifespan of Caenorhabditis elegans via regulating ferroptosis [0.03%]
一种磁性细菌Magnetospirillum magneticum AMB-1通过调节铁死亡延长线虫寿命
Yuting Ding,Xinyao Huang,Yanan Zhao et al.
Yuting Ding et al.
Magnetotactic bacteria (MTB), which contain special nano-magnetic particles within their cells, have been extensively studied for biomedical applications including drug delivery and cancer treatment. However, the practical application of ba...
CD200R protects against ulcerative colitis by regulating macrophage polarization and intestinal barrier function: evidence from human patients and mouse disease models [0.03%]
CD200R通过调节巨噬细胞极化和肠屏障功能防治溃疡性结肠炎：来自病人及疾病动物模型的证据
Xiaoming Liu,Yang Hu,Jin Wang et al.
Xiaoming Liu et al.
Background and objective: Ulcerative colitis (UC) is a chronic inflammatory disorder characterized by dysregulated mucosal immunity and impaired epithelial barrier function. CD200R is an inhibitory immune receptor involve...
Metabolism of the antioxidant micronutrient ergothioneine as a plasma biomarker of cognitive resilience in older people with Alzheimer's disease amyloid pathology [0.03%]
抗氧化微量营养素拟黑紫芝胺的代谢作为认知坚韧性的血浆生物标志物在具有阿尔茨海默病淀粉样蛋白病理学的老年人群中的作用
Joyce R Chong,Irwin K Cheah,Richard M Tang et al.
Joyce R Chong et al.
Background: Associations between dietary micronutrients and cognitive resilience to Alzheimer's disease (AD) amyloid pathology is currently unknown. We investigated whether plasma levels of L-ergothioneine (ET), its metab...
Rosuvastatin ameliorates high-altitude cerebral edema by promoting blood-brain barrier integrity via the regulation of energy metabolism [0.03%]
rosuvastatin通过调节能量代谢促进血脑屏障完整性从而改善高原脑水肿
Hong Jin,Bing Han,Jun He et al.
Hong Jin et al.
High-altitude cerebral edema (HACE) is a severe and potentially fatal neurological condition resulting from acute exposure to hypobaric hypoxia. This condition is characterized by the disruptions of endothelial tight junctions, triggering b...
Stabilization of Keap1 by alkannin triggers ferroptotic cell death in colorectal cancer via suppression of the Nrf2/GPX4 signaling [0.03%]
通过抑制Nrf2/GPX4信号传导触发铁死亡诱导结直肠癌细胞死亡的新机制：穿山龙内酯D稳定Keap1蛋白的作用研究
Hong Yu,Jiyao Liu,Rui Han et al.
Hong Yu et al.
Colorectal cancer (CRC) is one of the most common and deadly types of cancer globally. Ferroptosis, a type of regulated cell death that relies on iron, has become a promising target for treating CRC. Alkannin, a natural compound from Lithos...
Gentamicin triggers fatty acid oxidation-dependent mitochondrial ROS, driving greater nephrotoxicity than apramycin and other aminoglycosides [0.03%]
新霉素触发脂肪酸氧化依赖性线粒体ROS，使其比阿普拉霉素和其他氨基糖苷类抗生素诱导更强的肾毒性
Edgars Liepinsh,Kristaps Krims-Dāvis,Helena Cirule et al.
Edgars Liepinsh et al.
Apramycin has emerged as a promising antibacterial drug candidate that has demonstrated great preclinical efficacy and safety profile. In comparative studies, apramycin was found to be significantly less nephrotoxic than gentamicin; however...
Impaired BCAA Catabolism in Macrophages Exacerbates Sepsis-Induced Lung Injury by Modulating Mitochondrial AGE-RAGE and mtDNA Release [0.03%]
巨噬细胞中支链氨基酸分解代谢受损通过调节线粒体糖基化终产物受体和线粒体DNA释放加重脓毒症诱导的肺损伤
Ying Hong,Yan Xu,Kaiteng Luo et al.
Ying Hong et al.
Although macrophage immunometabolism is a key contributor to the progression of sepsis-induced acute lung injury, the specific role of branched-chain amino acid (BCAA) catabolism in this process remains unclear. Here, we hypothesized that d...
Florian Gruber,Christina Bauer,Christopher Kremslehner
Florian Gruber
Selenium nanoparticles alleviate ulcerative colitis by regulating macrophage mitochondrial dynamics [0.03%]
硒纳米颗粒通过调节巨噬细胞线粒体动力学来缓解溃疡性结肠炎
Jiajing Chang,Xiaonan Zeng,Runan Zhang et al.
Jiajing Chang et al.
Ulcerative colitis (UC) progression is closely associated with aberrant macrophage polarization and mitochondrial dysfunction. Here, we explored how biogenic selenium nanoparticles (SeNPs) protect against experimental colitis, using dextran...