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Stabilization of Keap1 by alkannin triggers ferroptotic cell death in colorectal cancer via suppression of the Nrf2/GPX4 signaling

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Colorectal cancer (CRC) is one of the most common and deadly types of cancer globally. Ferroptosis, a type of regulated cell death that relies on iron, has become a promising target for treating CRC. Alkannin, a natural compound from Lithospermum erythrorhizon... ...