Gentamicin triggers fatty acid oxidation-dependent mitochondrial ROS, driving greater nephrotoxicity than apramycin and other aminoglycosides
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Apramycin has emerged as a promising antibacterial drug candidate that has demonstrated great preclinical efficacy and safety profile. In comparative studies, apramycin was found to be significantly less nephrotoxic than gentamicin; however, the underlying mec... ...
