Cystathionine β-synthase inhibition is a potential therapeutic approach to treatment of ischemic injury [0.03%]
胱硫醚-β-合成酶抑制可能是治疗缺血损伤的潜在方法
Su Jing Chan,Chou Chai,Tze Wei Lim et al.
Su Jing Chan et al.
Hydrogen sulfide (H2S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine β-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system. When SH-SY5Y cells were tra...
Pengcheng Han,Bradley J Trinidad,Jiong Shi
Pengcheng Han
Calcium is essential for both neurotransmitter release and muscle contraction. Given these important physiological processes, it seems reasonable to assume that hypocalcemia may lead to reduced neuromuscular excitability. Counterintuitively...
Caspase-mediated apoptosis in the cochleae contributes to the early onset of hearing loss in A/J mice [0.03%]
耳皮层凋亡介导的 caspase 凋亡参与了小鼠早期听力损失的发生与发展
Xu Han,Ruli Ge,Gang Xie et al.
Xu Han et al.
A/J and C57BL/6 J (B6) mice share a mutation in Cdh23 (ahl allele) and are characterized by age-related hearing loss. However, hearing loss occurs much earlier in A/J mice at about four weeks of age. Recent study has revealed that a mutatio...
Antitumor activity of a polypyridyl chelating ligand: in vitro and in vivo inhibition of glioma [0.03%]
一类多吡啶配体的抗肿瘤活性研究：体内外抑制胶质瘤作用
Clément N David,Elma S Frias,Catherine C Elix et al.
Clément N David et al.
Glioblastoma multiforme is an extremely aggressive and invasive form of central nervous system tumor commonly treated with the chemotherapeutic drug Temozolomide. Unfortunately, even with treatment, the median survival time is less than 12 ...
Identifying the threshold of iron deficiency in the central nervous system of the rat by the auditory brainstem response [0.03%]
通过听性脑干反应识别铁缺乏对大鼠中枢神经系统影响的阈值
Allison R Greminger,Margot Mayer-Pröschel
Allison R Greminger
The deleterious effects of anemia on auditory nerve (AN) development have been well investigated; however, we have previously reported that significant functional consequences in the auditory brainstem response (ABR) can also occur as a con...
A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis [0.03%]
肝脏激酶B1基因（丝裂原活化蛋白激酶和丝氨酸苏氨酸激酶11）的单核苷酸多态性是多发性硬化症的风险因素
Anne I Boullerne,Demetrios Skias,Elizabeth M Hartman et al.
Anne I Boullerne et al.
We identified a family in which five siblings were diagnosed with multiple sclerosis (MS) or clinically isolated syndrome. Several women in the maternal lineage have comorbidities typically associated with Peutz Jeghers Syndrome, a rare aut...
Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis [0.03%]
GM₁神经节苷脂贮积症小鼠视神经和坐骨神经髓鞘异常病理学研究
Karie A Heinecke,Adrienne Luoma,Alessandra d&#x;Azzo et al.
Karie A Heinecke et al.
GM1-gangliosidosis is a glycosphingolipid lysosomal storage disease involving accumulation of GM1 and its asialo form (GA1) primarily in the brain. Thin-layer chromatography and X-ray diffraction were used to analyze the lipid content/compo...
Control of human PLP1 expression through transcriptional regulatory elements and alternatively spliced exons in intron 1 [0.03%]
人类PLP1基因通过转录调控元件和第一内含子选择性剪接外显子表达的调节控制机制研究
Hamdan Hamdan,Neriman T Kockara,Lee Ann Jolly et al.
Hamdan Hamdan et al.
Although the myelin proteolipid protein gene (PLP1) encodes the most abundant protein in central nervous system (CNS) myelin, not much is known about the mechanisms that govern expression of the human gene (hPLP1). Much more is known about ...
Paolo Riccio,Rocco Rossano
Paolo Riccio
The question whether dietary habits and lifestyle have influence on the course of multiple sclerosis (MS) is still a matter of debate, and at present, MS therapy is not associated with any information on diet and lifestyle. Here we show tha...
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22 [0.03%]
诱导型HSP70对预防PMP22聚集及促进其加工至关重要
Vinita G Chittoor-Vinod,Sooyeon Lee,Sarah M Judge et al.
Vinita G Chittoor-Vinod et al.
Chaperones, also called heat shock proteins (HSPs), transiently interact with proteins to aid their folding, trafficking, and degradation, thereby directly influencing the transport of newly synthesized molecules. Induction of chaperones pr...