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Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis

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GM1-gangliosidosis is a glycosphingolipid lysosomal storage disease involving accumulation of GM1 and its asialo form (GA1) primarily in the brain. Thin-layer chromatography and X-ray diffraction were used to analyze the lipid content/composition and the myeli... ...