Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages [0.03%]
一线抗逆转录病毒药物多替拉韦暴露会干扰不同分化阶段少突胶质细胞的发育
Marisa A Jeffries,Raj Putatunda,Melanie Cruz-Berríos et al.
Marisa A Jeffries et al.
The use of antiretroviral (ART) treatment during pregnancy has dramatically reduced rates of perinatally-acquired human immunodeficiency virus 1 (HIV-1) infection to
Membrane Molecular Species Remodeling as a Signature of ω-3 Fatty Acid Action in Cultured Neural Cells [0.03%]
膜分子组分重建是欧米伽-3脂肪酸作用于培养神经细胞的标志
Kyndall R Nicholas,Hennrique Taborda Ribas,Kevin D Browne et al.
Kyndall R Nicholas et al.
Omega-3 polyunsaturated fatty acids (ω3 PUFAs) are critical structural components of neuronal membranes, yet the molecular specificity of their incorporation within neural cells remains incompletely defined. We integrated untargeted and ta...
Reboxetine Treatment Reduces Hippocampal Gliosis in the P301S Tauopathy Mouse Model [0.03%]
临床前期tau病小鼠模型中的回斯替品治疗降低海马胶质增生
Irene L Gutiérrez,Claudia Yanes-Castilla,Karina S MacDowell et al.
Irene L Gutiérrez et al.
The loss of brain noradrenergic neurons is one of the earliest alterations observed in Alzheimer's disease and other neurodegenerative pathologies. The consequent reduction of brain noradrenaline levels facilitates the progression of neuroi...
Targeting NLRP3 Inflammasome and Metabolic Dysregulation by Electroacupuncture: A Novel Therapeutic Strategy for Methamphetamine Withdrawal-Induced Depression [0.03%]
电针针对甲基苯丙胺戒断抑郁的治疗新策略：作用于NLRP3炎症小体和代谢失衡
Xiong Zhang,Xiao-Rui Zhao,Chun-Li You et al.
Xiong Zhang et al.
This study demonstrates that electroacupuncture (EA) produces robust antidepressant effects in a rat model of methamphetamine (METH) withdrawal. Behavioral tests showed that EA applied at GV20, PC6, and HT7 significantly reduced immobility ...
Luana Campos Soares,Hana Bernhardova,Francis G Szele
Luana Campos Soares
Galectin-3 (Gal-3) is a protein expressed by glia that belongs to an ancient family. Gal-3 recognises molecular patterns on pathogens due to the high degree of its binding specificity with carbohydrate recognition domains. Thus, in sponges ...
GABA Receptor Activation in Müller Glia as a Molecular Switch for Controlling VEGF-A in the Retina [0.03%]
视网膜中Müller胶质细胞中的GABA受体激活作为控制VEGF-A的分子开关
Alan E Medina-Arellano,Jesus Silvestre Albert-Garay,Karla Tovar-Hernandez et al.
Alan E Medina-Arellano et al.
GABA receptors are classically known for driving neuronal hyperpolarization and modulating synaptic transmission. In glial cells, however, GABA induces depolarization and triggers calcium-dependent signaling pathways. Müller glia, the prin...
Disrupted Vitamin D Signaling and Metabolism in Neurodevelopmental and Neurodegenerative Disorders [0.03%]
神经发育障碍和神经退行性疾病中维生素D信号传导和代谢的紊乱
Nasim Khatibi,Jessica L MacDonald
Nasim Khatibi
Vitamin D is a secosteroid hormone with myriad physiological functions, including pleiotropic effects in the central nervous system. Vitamin D deficiency has been linked to multiple neurodevelopmental and neurodegenerative diseases, includi...
Sanaz Bordbar,Sina Molavizade,Fateme Dehghani et al.
Sanaz Bordbar et al.
Cerebral ischemia is defined by insufficient blood supply to the brain and is a leading cause of mortality and neurological disability worldwide. Alpha-synuclein (α-Syn) is a protein associated with several neurodegenerative disorders, inc...
Maxwell K Foote,William C Huffman,Erin N Santos et al.
Maxwell K Foote et al.
Classic experiments showing that monocular visual disruption alters synaptic connections to binocular neurons established the fundamental concept of synaptic plasticity. Synaptic inputs that are activated coincidently with postsynaptic acti...
Loss of Fatty Acid Oxidation by Neural Stem and Progenitor Cells Increases Proliferation but Does Not Improve Long-Term Neurogenesis After Mild Traumatic Brain Injury [0.03%]
神经干细胞和前体细胞脂肪酸氧化丧失可增加增殖，但不会改善轻度脑损伤后的长期神经发生
Javier Allende Labastida,Regina F Fernandez,Tiffany Chu et al.
Javier Allende Labastida et al.
Neurogenesis in the dentate gyrus of the hippocampus is a conserved and highly regulated process throughout the lifespan. Hippocampal neural stem and progenitor cells (NSPCs) can either transition into an activated proliferative state or re...