The CEMIP Hyaluronidase is Elevated in Oligodendrocyte Progenitor Cells and Inhibits Oligodendrocyte Maturation [0.03%]
CEMIP 胶尿酸酶在少突胶质前体细胞中高表达并抑制少突胶质细胞的成熟
Alec Peters,Kanon Yasuhara,Weiping Su et al.
Alec Peters et al.
Central nervous system (CNS) demyelination occurs in numerous conditions including multiple sclerosis (MS). CNS remyelination involves recruitment and maturation of oligodendrocyte progenitor cells (OPCs). Remyelination often fails in part ...
Global Deficiency of Alzheimer's Disease Risk Gene Il1rap Reduces Pathological Tau in a Mouse Model of Systemic Inflammation [0.03%]
载脂蛋白ε4等位基因阴性的小鼠tau病理学的系统性炎症反应机制研究
Somayeh Dadras,Kiran Bhaskar
Somayeh Dadras
Brain inflammation is strongly associated with neurodegeneration in Alzheimer's disease (AD) and related tauopathies. We have previously demonstrated that microglia-derived interleukin-1β (IL-1β) induces tau hyperphosphorylation in a cell...
Dual Stages of Alcohol-Related Cerebral White Matter Degeneration Reviewed: Early-Stage Stress/Neuroinflammation Versus Late-Stage Impaired Insulin/IGF Signaling Through Akt-mTOR-Review [0.03%]
酒精相关脑白质退行性变的双阶段：早期应激/神经炎症与晚期胰岛素/IGF信号缺陷通过Akt-mTOR-综述
Suzanne M de la Monte,Greg Sutherland
Suzanne M de la Monte
Long-term effects of alcohol-related brain damage (ARBD) include neurocognitive and neurobehavioral dysfunctions with neurodegeneration. White matter (WM) is notably targeted across the lifespan yet relatively little is known about the stag...
Combined Treatment with Minocycline and an mGluR5 Antagonist Alters Resting EEG Spectral Power, but Not Sound-Evoked Responses, in a Mouse Model of Fragile X Syndrome [0.03%]
二氢麦角碱与mGluR5拮抗剂联合治疗改变脆弱X染色体综合征小鼠模型静息EEG谱功率，但不影响声音诱发反应
M H Kassir,J W Lovelace,D K Binder et al.
M H Kassir et al.
Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism-like behaviors. Glutamatergic mGluR5 receptors and matrix metalloproteinase-9 (MMP-9) are therapeutic targets to treat FXS, but clinical trials target...
Demystifying The Myelin g Ratio: Its Origin, Derivation and Interpretation [0.03%]
揭秘轴突髓鞘g比率：它的起源、推导和解读
Alexander Gow
Alexander Gow
Most studies involving myelin g ratios over the past 120 years assume this metric enumerates differences in myelin thickness (larger g ratio = thinner myelin) with axon or fiber diameter. And, moreover, such changes are directly correlated ...
Dysregulated Expression of Inflammasome and Extracellular Matrix Genes in C9orf72-ALS/FTD Microglia [0.03%]
C9orf72-ALS/FTD小胶质细胞中炎症小体和基质基因的表达失调
Louise Thiry,Nisha S Pulimood,Ye Man Tang et al.
Louise Thiry et al.
Hexanucleotide repeat expansion (HRE) in the non-coding region of the gene C9orf72 is the most prevalent mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The C9orf72 HRE contributes to neuron degeneration i...
Identifying Lanthionine Ketimine Derivatives for Maturation and Proliferative Effects in Oligodendrocyte Progenitor Cells [0.03%]
用于少突胶质前体细胞成熟和增殖的 lanthionine ketimine 衍生物的鉴定
Zachary McDonald,Ankit Tandon,Travis T Denton et al.
Zachary McDonald et al.
Previous studies have shown that lanthionine ketimine ethyl ester (LKE) reduces clinical scores in the experimental autoimmune encephalomyelitis (EAE) mouse model of Multiple Sclerosis, induces differentiation of oligodendrocyte progenitor ...
Cortical Stimulation-Based Transcriptome Shifts on Parkinson's Disease Animal Model [0.03%]
基于皮层电刺激的帕金森病动物模型转录组变化研究
Johyeon Nam,Hongseong Shin,Chaeyeon You et al.
Johyeon Nam et al.
Parkinson's disease is the second most prevalent neurodegenerative disorder and is characterized by the degeneration of dopaminergic neurons. Significant improvements in gait balance, particularly in step length and velocity, were observed ...
Analysis of Oligodendrocyte Lineage Cell Progression with Cre-Mediated RiboTag Reporter Lines [0.03%]
Cre重组酶介导的RiboTag报告系在少突胶质细胞谱系细胞分化中的应用分析研究
George S Melchor,Maya S Shah,Zeeba Manavi et al.
George S Melchor et al.
Cre-reporter strategies in transgenic mice are widely used to assess the specificity of gene promoter activities, and for fate-mapping studies during development and under injury conditions. The ribosome tagging strategy, RiboTag, is a tran...
Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease [0.03%]
阿尔茨海默病中增殖的小胶质细胞表现出独特的转录和功能变化
Nàdia Villacampa,Heela Sarlus,Paula Martorell et al.
Nàdia Villacampa et al.
Proliferation of microglia represents a physiological process, which is accelerated in several neurodegenerative disorders including Alzheimer disease (AD). The effect of such neurodegeneration-associated microglial proliferation on functio...