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Joseph Jr Asante Jr,Steven W Barger Joseph Jr Asante Jr
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects more than 50 million people worldwide. One of the hallmark features of AD is the accumulation of amyloid β-peptide (Aβ) protein in the brain. P-glycoprotein...
Assessment of Phase-Dependent Alterations in Cortical Glycolytic and Mitochondrial Metabolism Following Ischemic Stroke [0.03%] 缺血性卒中后皮质糖酵解和线粒体代谢相依赖性改变的评估
Shokofeh Rahimpour,Ethan Meadows,John M Hollander et al. Shokofeh Rahimpour et al.
Maintaining optimal brain metabolism supports neuronal function, synaptic communication, and cognitive processes. During ischemic stroke, brain metabolism and cellular bioenergetics within the neurovascular unit are disrupted, emphasizing t...
R Douglas Fields,Dipankar J Dutta R Douglas Fields
Advances in Research on Exosomal miRNAs in Central Nervous System Diseases [0.03%] 中枢神经系统疾病中外泌体miRNAs的研究进展
Guangli Feng,Xiaoqian Lan,Shiyi Qin et al. Guangli Feng et al.
Neurological diseases present a wide range of conditions, intricate diagnosis and treatment processes, and complex prognostic considerations. Therefore, research focusing on the diagnosis and treatment of these diseases is crucial. Exosomal...
A Brain Endothelial Cell Caveolin-1/CXCL10 Axis Promotes T Cell Transcellular Migration Across the Blood-Brain Barrier [0.03%] 脑血管内皮细胞的洞蛋白-1/ CXCL10 轴促进T细胞穿越血脑屏障发生迁移
Troy N Trevino,Ali A Almousawi,Remy Martins-Goncalves et al. Troy N Trevino et al.
The mechanisms that govern whether T cells cross blood-brain barrier (BBB) endothelium by transcellular versus paracellular routes are unclear. Caveolin-1 is a membrane scaffolding and signaling protein associated with transcellular transmi...
A Statistically-Robust Model of the Axomyelin Unit under Normal Physiologic Conditions with Application to Disease States [0.03%] 正常生理条件下轴突-髓鞘单位的统计学稳健模型及其在病理状态下的应用
Alexander Gow,Jeffrey L Dupree,Douglas L Feinstein et al. Alexander Gow et al.
Despite tremendous progress in characterizing the myriad cellular structures in the nervous system, a full appreciation of the interdependent and intricate interactions between these structures is as yet unfulfilled. Indeed, few more so tha...
Joyce Benjamins,Pamela Knapp,Anne Boullerne Joyce Benjamins
Understanding the Myelin g Ratio from First Principles, Its Derivation, Uses and Artifacts [0.03%] 从第一性原理理解髓鞘g比值及其推导、用途和伪像
Alexander Gow Alexander Gow
In light of the increasing importance for measuring myelin g ratios - the ratio of axon-to-fiber (axon + myelin) diameters in myelin internodes - to understand normal physiology, disease states, repair mechanisms and myelin plasticity, ther...
Neurons Are Not All the Same: Diversity in Neuronal Populations and Their Intrinsic Responses to Spinal Cord Injury [0.03%] 神经元并不相同：神经元群体的多样性及其对脊髓损伤的内在反应
Justin R Siebert,Kiersten Kennedy,Donna J Osterhout Justin R Siebert
Functional recovery following spinal cord injury will require the regeneration and repair of damaged neuronal pathways. It is well known that the tissue response to injury involves inflammation and the formation of a glial scar at the lesio...
New Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia [0.03%] 新发现的Atg9磷酸化位点调节胶质细胞自噬转运
Linfang Wang,Shuanglong Yi,Shiping Zhang et al. Linfang Wang et al.
We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect the mechanism, we present evidence here that lack of glial d...