SP1 Aggravates Neonatal Hypoxic-Ischemic Brain Damage by Promoting Ferroptosis Through Transcriptional Upregulation of ACSL4 [0.03%]
SP1通过转录上调ACSL4促进铁死亡从而加重新生儿缺氧缺血性脑损伤
Shuting Chang,Weiqing Huang,Biao Yi et al.
Shuting Chang et al.
Neonatal hypoxic-ischemic brain damage (HIBD) is a major cause of neurological disability. This study investigated the role of the transcription factor specificity protein 1 (SP1) and its target, Acyl-CoA Synthetase Long-Chain Family Member...
IL-4-Primed Microglial Extracellular Vesicles Attenuate Rotenone-Induced Cell Death in SH-SY5Y Cells: A Contributory Role for miR-191-5p [0.03%]
经IL-4诱导的微胶质细胞外泌体通过miR-191-5p减轻罗虫素致SH-SY5Y细胞损伤
Kemal Ugur Tufekci,Burak I Arioz,Aysen Cotuk et al.
Kemal Ugur Tufekci et al.
Microglia contribute to central nervous system homeostasis and neuroprotection partly through the release of small extracellular vesicles (sEVs) carrying regulatory cargoes such as microRNAs. Interleukin-4 (IL-4) alters microglial state and...
Endothelin-1 Signaling Mediates Hypoxia-Induced Microglial Activation Through Reactive Oxygen Species and Mitogen-Activated Protein Kinase Pathways [0.03%]
内皮素-1信号通过活性氧和丝裂原活化蛋白激酶介导缺氧诱导的小胶质细胞激活
Yandy Garcia,Ricardo Vázquez,Yalimar P Pomales-Inostroza et al.
Yandy Garcia et al.
Oxidative stress and neuroinflammation are critical contributors to hypoxic-ischemic brain injury. Microglia, the CNS-resident immune cells, undergo rapid activation in response to hypoxic stress. Endothelin-1 (ET-1), a vasoconstrictor impl...
Mild Subcortical Stroke Induces Widespread Chronic Reactive Astrogliosis That Is Largely Unaffected by Microglia and Age [0.03%]
轻度皮质下卒中诱导的广泛慢性星形胶质细胞反应增生不受小胶质细胞和年龄影响
Teresa L Stackhouse,Bradley D Marxmiller,Steve J Sullivan et al.
Teresa L Stackhouse et al.
Ischemic stroke induces a plethora of pathophysiological changes, including neuroinflammation and chronic cerebrovascular dysfunction. In humans, even small, silent strokes can trigger these pathologies, which can spread to brain regions fa...
Hijacking Sodium-Glucose Cotransporters: Fructose Drives Neuronal and Microglial Dysfunction [0.03%]
劫持钠-葡萄糖同向转运蛋白：果糖驱动神经元和小胶质细胞功能障碍
Salaheldeen Elsaid,Muhammad Asad Usmani,Xiangdong Wu et al.
Salaheldeen Elsaid et al.
Excess fructose consumption has been implicated in metabolic disease, yet its impact on brain physiology and cellular metabolism remains poorly understood. The hippocampus expresses fructose transporters and fructolytic enzymes, suggesting ...
Uric Acid Released from Poly (Lactic-co-Glycolic Acid) Nanoparticles Mitigates Glutamate-Induced Excitotoxicity of Spinal Cord Neurons [0.03%]
聚乳酸-乙醇酸共聚物纳米颗粒释放尿酸可缓解脊髓神经元谷氨酸兴奋毒性损伤
Kaavyashri Anbumani,Brandon J Vaglio,Agam Aviv et al.
Kaavyashri Anbumani et al.
Spinal cord injury (SCI) is often compounded by secondary damage caused by glutamate-induced excitotoxicity (GIE), where excessive glutamate release results in neuronal damage by overstimulation of glutamate receptors. This process leads to...
Border-Associated Macrophages in CNS Health and Disease: A Comprehensive Review of Ontogeny, Heterogeneity, and Functional Plasticity at Neural Interfaces [0.03%]
中枢神经系统健康与疾病的边界相关巨噬细胞：神经界面发生、异质性和功能可塑性的全面综述
Xueting Liu,Mingyue Li,Zengrong Wei et al.
Xueting Liu et al.
Border-associated macrophages (BAMs) represent a specialized population of tissue-resident immune cells strategically positioned at the critical interfaces between the central nervous system (CNS) and peripheral circulation, including the m...
Angela M Mabb,Dhanya N Pyaram,Jayshree Samanta
Angela M Mabb
Protein ubiquitination is a type of posttranslational modification that occurs in all cells to regulate numerous biological processes. Ubiquitination of proteins is carried out by an enzymatic cascade where E3 ubiquitin ligases facilitate t...
Progress in Research on the Mechanisms and Therapeutic Targets of Ferroptosis in Peripheral Nerve Injury and Repair [0.03%]
外周神经损伤与修复中铁死亡机制及治疗靶点研究进展
Jian Ruan,Xin-Kun He,Song-Ou Zhang et al.
Jian Ruan et al.
Repair after peripheral nerve injury (PNI) faces major obstacles due to microenvironmental imbalance and neuronal loss. Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, has emerged as a key pathological event in PNI, ...
Polyglutamine-Expanded Ataxin-3 Accelerates CFTR Degradation Through K63-Linked Ubiquitination to Exacerbate Microglial Inflammation [0.03%]
多聚谷氨酰胺扩增的Ataxin-3通过K63连接的泛素化促进CFTR降解以加剧小胶质细胞炎症响应
Zixin Wang,Xue Fan,Bingbing Bai et al.
Zixin Wang et al.
The deubiquitinase Ataxin-3 causes spinocerebellar ataxia type 3 (SCA3) upon polyglutamine (polyQ) expansion. While expressed in the nervous system, the function of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride cha...