Integrative Single-Cell and Bulk Transcriptomic Analysis Defines a Molecular Stratification Strategy Based on Intra-Tumoral Heterogeneity in Acral Melanoma [0.03%]
整合单细胞和批量转录组分析基于肢端黑色素瘤肿瘤内异质性定义分子分层策略
Ziqi Gong,Fenghao Zhang,Ke Xiao et al.
Ziqi Gong et al.
Acral melanoma (AM) is a rare subtype of melanoma with high malignancy. Although the transcriptional landscape of the tumor microenvironment (TME) in AM has been characterized, the heterogeneity of malignant cells and underlying molecular f...
Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer [0.03%]
黏膜黑色素瘤的临床前和虚拟模型：一种罕见且致命癌症的转化缺口桥梁
Xiangjie Jin,Yuhan Zhang,Yuantai Zhu et al.
Xiangjie Jin et al.
Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct clinicopathological and genetic features compared to cutaneous melanoma (CM). Often diagnosed at advanced...
Copy Number Analysis in Congenital Nevi: Concordance and Diagnostic Limitations of aCGH, sWGS, and Methylation Sequencing [0.03%]
先天性黑素细胞痣的拷贝数分析：aCGH、sWGS和甲基化测序的一致性和诊断局限性
Anton Karelin,Ines B Brecht,Michaela Pogoda et al.
Anton Karelin et al.
Distinguishing benign proliferative nodules (PNs) from melanoma arising within congenital melanocytic nevi remains a major diagnostic challenge. Copy number alteration (CNA) analysis is widely used to support classification, but current cri...
Development of Poliosis in Patients Treated With Immunotherapy for Metastatic Cutaneous and Non-Cutaneous Melanoma [0.03%]
免疫治疗后发生白发的黑色素瘤患者临床分析
Kimberly Smart,Ivan Rodriguez,Mark S Swanson et al.
Kimberly Smart et al.
While prior studies have described the development of vitiligo and alopecia among patients with metastatic melanoma undergoing cancer immunotherapy, there are scant reports of secondary poliosis. Here we detail a case series of patients wit...
Haley P Wilson,Casey D Stefanski,Signe Caksa et al.
Haley P Wilson et al.
NRAS mutations occur in 10%-30% of cutaneous melanomas and are associated with high tumor mutational burden. Mutant NRAS signaling drives aberrant cell growth and proliferation, in part, through activation of the RAF-MEK-ERK1/2 kinase pathw...
Comparison of Disease Progression Between Amelanotic Melanoma and Melanotic Melanoma [0.03%]
无色素性黑色素瘤和有色素性黑色素瘤的疾病进展情况比较
Barzilai Aviv,Barnea Hamama Noa,Levin Lotan et al.
Barzilai Aviv et al.
Amelanotic melanoma lacks melanin and is more challenging to diagnose than pigmented melanoma, often leading to delayed detection and worse outcomes. We conducted a retrospective cohort study of 322 patients (28 with amelanotic melanoma and...
Comparative Study
Pigment cell & melanoma research. 2026 May;39(3):e70083. DOI:10.1111/pcmr.70083 2026
Keiran S M Smalley,Joan Levy
Keiran S M Smalley
Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation-Wide Study by the Italian Melanoma Intergroup (IMI) [0.03%]
意大利黑色素瘤联盟（IMI）开展的一项全国性研究：解析黑色素瘤罕见BRAF突变谱系
Bruna Dalmasso,Maria Chiara Scaini,Laura Cendron et al.
Bruna Dalmasso et al.
Non-V600E/K BRAF mutations have been reported in melanoma, but data on their clinical relevance are conflicting. This study investigated the distribution, prognostic role, and functional impact of rare BRAF mutations in melanoma. We retrosp...
Multicenter Study
Pigment cell & melanoma research. 2026 May;39(3):e70087. DOI:10.1111/pcmr.70087 2026
A New Era in Leptomeningeal Disease (LMD): Recent Advancements in Immunocellular and Radiation Therapies in Melanoma LMD, What Has Been Done and Future Directions [0.03%]
莱朴脑膜病变(LMD)的新时代：黑色素瘤LMD中免疫细胞和放射疗法的最新进展，迄今为止已完成的工作及未来方向
Pratiksha Patra,Maria Jacome,Kamran A Ahmed et al.
Pratiksha Patra et al.
Leptomeningeal disease (LMD) or leptomeningeal metastases (LM) occurs when tumor cells invade the leptomeningeal and cerebrospinal fluid (CSF) space. Melanoma is the most common cancer causing LMD (M-LMD). Its biology and pathophysiology ar...
Haplotype-Based Analysis of OCA2 Variants in Oculocutaneous Albinism [0.03%]
基于合子分析OCA2变异在曲菌素皮肤眼睛 albinism中的作用
Meredith F Gillis,Madeleine R Ames,Linnea Lundh et al.
Meredith F Gillis et al.
OCA2, a melanosome transmembrane spanning protein, functions to regulate melanosomal pH, optimizing production of melanin pigment. OCA2 is one of eight non-syndromic autosomal recessive oculocutaneous albinism (OCA) loci and is the second m...