CD40 Agonist Therapy in Melanoma: Translating Preclinical Promise Into Clinical Practice [0.03%]
黑色素瘤中CD40激动剂治疗：将前期研究的希望转化为临床实践
Xing Wei,YanDong Li,DeXuan Gao
Xing Wei
Melanoma is an aggressive skin cancer that, once metastatic, accounts for a disproportionate share of skin-cancer mortality. Contemporary management includes surgical excision with sentinel-node assessment, adjuvant or neoadjuvant systemic ...
A Recessive oca2 Mutation Underlies Albinism in Xiphophorus Fish [0.03%]
一种 recessive oca2 突变导致了丽鱼科鱼类的白化病
Yanting Xing,William Boswell,Jessica Parker et al.
Yanting Xing et al.
Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by impaired melanin production, leading to reduced pigmentation in the skin, hair, and eyes. Xiphophorus, a genus of small freshwater fish, has been a pivotal model...
Luisa Quesada Camacho,Mohamad El Moheb,Mackenzie M Mayhew et al.
Luisa Quesada Camacho et al.
In-transit melanoma (ITM) is a unique presentation of metastatic cutaneous melanoma associated with therapeutic challenges. Despite its clinical importance, the molecular drivers of ITM remain poorly defined. We aimed to characterize the mu...
Kevin O&#x;Neill
Kevin O&#x;Neill
Patients who receive a rare cancer diagnosis begin a diagnostic and treatment journey which is complicated by personal fear of the unknown and the reality of a scientific and clinical research community which may not have many insights, opt...
Lindsey Byrne,Isabella Gray,Kaylee Ramsey et al.
Lindsey Byrne et al.
Germline genetic testing is increasingly incorporated into the care of patients with uveal melanoma, yet optimal testing strategies remain unclear. This study aimed to evaluate the outcome of germline clinical genetic testing in uveal melan...
Copying the Risk: Rise of Phenocopies in CDKN2A Spanish Families [0.03%]
CDKN2A西班牙家族中表观遗传风险拷贝的现象增多现象
Luna Amalia,Potrony Miriam,Badenas Celia et al.
Luna Amalia et al.
Histopathological Analysis Revealed Melanosome-Retaining Fibroblasts and Autophagy-Impaired Macrophages in Ashy Dermatosis [0.03%]
组织病理分析发现灰黑色皮肤病中黑素体滞留的成纤维细胞和自噬异常的巨噬细胞
Motoki Hada,Kazunori Yokoi,Daiki Murase et al.
Motoki Hada et al.
Ashy dermatosis is a rare acquired dermal hyperpigmented disorder classified as a subtype of macular pigmentation of uncertain etiology. Recent studies have suggested that fibroblasts, in addition to macrophages known as melanophages, can p...
Heme Oxygenase-1 Differentially Controls Pigmentation in Physiological and Pathological Melanogenesis [0.03%]
血红素氧化酶1通过不同机制调控生理和病理黑素生成中的色素沉着
Agnieszka Seretny,Grażyna Jamróg,Jacek Stępniewski et al.
Agnieszka Seretny et al.
Melanogenesis is a defining feature of melanocyte biology and influences melanoma pathogenesis; however, tumor-specific regulators of this process remain incompletely understood. Here, we investigate how heme oxygenase-1 (HO-1) regulates pi...
Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights in Disease Control [0.03%]
人黑色素瘤单细胞谱系对比进化医学模式动物剑尾鱼研究为疾病控制提供新思路
Yuan Lu,Will Boswell,Rachel Carroll et al.
Yuan Lu et al.
Melanoma remains one of the deadliest forms of cancer. Despite recent therapeutic advances, including immune checkpoint inhibitors and small-molecule kinase inhibitors, patients frequently develop treatment resistance. Novel models are need...
Comparative Study
Pigment cell & melanoma research. 2026 Jul;39(4):e70106. DOI:10.1111/pcmr.70106 2026
Genome-Wide Association Study of Nevus Count Reveals Opposing Effects of Genetic Loci Near IRF4 and MC1R on Flat Versus Raised Nevus Count in the Brisbane Twin Nevus Study: A Cross-Sectional Analysis [0.03%]
布里斯班双生痣研究的nevus计数全基因组关联分析显示，IRF4和MC1R位点附近的遗传多态性对扁平与凸起nevus的数量具有相反的影响：一项横断面分析
Nathan Ingold,Gu Zhu,David L Duffy et al.
Nathan Ingold et al.
Germline genetic variation can influence the number of nevi on the skin. However, nevi can be classified in many ways (e.g., by shape, size or evolution); little is known of how genetics influences the density of different nevus morphologie...