Diacylglycerol Kinase Eta as a Novel Target in NRAS Mutant Melanoma
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NRAS mutations occur in 10%-30% of cutaneous melanomas and are associated with high tumor mutational burden. Mutant NRAS signaling drives aberrant cell growth and proliferation, in part, through activation of the RAF-MEK-ERK1/2 kinase pathway; however, targete... ...
