Inhibition of STING pathway attenuates experimental abdominal aortic aneurysm progression [0.03%]
STING信号通路的抑制可减缓实验性腹主动脉瘤的发展
Yu-Xin Chen,Chen-Rui Shen,Fang-Fang Xu et al.
Yu-Xin Chen et al.
Abdominal aortic aneurysm (AAA) is a chronic, inflammatory and degenerative vascular disease. Previous studies have demonstrated that stimulator of interferon genes (STING) is involved in multiple inflammatory diseases. However, the role of...
Histone methyltransferase G9a drives vascular smooth muscle cell proliferation and intimal hyperplasia in mice [0.03%]
组蛋白甲基转移酶G9a驱动小鼠血管平滑肌细胞增殖和内膜增生
Si-Tong Liu,Shao-Wei Liu,Shi-Yi He et al.
Si-Tong Liu et al.
Abnormal proliferation of vascular smooth muscle cells (VSMCs) plays a critical role in vascular remodeling associated with various cardiovascular disorders. G9a, also known as euchromatic histone methyltransferase 2 (EHMT2), is a lysine me...
PDE4 inhibitor rolipram dynamically regulates the balance between D1-MSNs and D2-MSNs in the DMS to modulate abnormal "Go" behavior associated with alcohol addiction [0.03%]
PDE4抑制剂Rolipram动态调节DMS中D1-MSNs和D2-MSNs平衡以调控与酒精成瘾相关的异常的“Go”行为
Wei Zhao,Shuang Zhao,Zi-Qi Wang et al.
Wei Zhao et al.
Addiction is a chronic relapsing disorder characterized by compulsive seeking and consumption of drugs, with this abnormal "Go" behavior resulting in significant negative consequences. Research has shown that the dorsal medial striatum (DMS...
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery [0.03%]
脑靶向脂质体递送使C19成为胶质瘤免疫治疗的CSF1R抑制剂
Wen-Qin Song,Yue-Qian Wu,Quan-Feng Zhu et al.
Wen-Qin Song et al.
Immunotherapy targeting tumor-associated macrophages (TAMs) has emerged as a promising approach for treating glioma, driven by advances in drug discovery and development, including colony-stimulating factor 1 receptor (CSF1R) inhibitors. We...
Rebalancing the inflammatory trajectory from inflammatory bowel disease to colitis-associated colorectal cancer via artemisinin-based multitarget therapy [0.03%]
基于青蒿素的多靶点治疗调节炎症性肠病炎至相关结直肠癌的轨迹
Shi-Jun He,Mei-Lin Tang,Li Chen et al.
Shi-Jun He et al.
Inflammatory bowel disease (IBD) comprises Crohn's disease and ulcerative colitis, and that is a major risk factor for colitis-associated colorectal cancer (CAC), a distinct and aggressive malignancy driven by chronic intestinal inflammatio...
Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma [0.03%]
异 citrusin 通过靶向 HDAC8/CXCL10 轴促进肝细胞癌中 CD8+T 细胞介导的抗肿瘤免疫
Yu-Chuan Chen,Xue-Lian Gao,Ge Zeng et al.
Yu-Chuan Chen et al.
Immunotherapy has shown limited efficacy in hepatocellular carcinoma (HCC) due to the immunosuppressive tumor microenvironment (TME). Previous studies show that asiatic acid (AA), a naturally occurring pentacyclic triterpenoid, exhibits pot...
Epigenetic regulation and posttranslational modifications of FXR: underlying mechanisms and implications in digestive diseases [0.03%]
FXR表观遗传调控和翻译后修饰：潜在机制及其在消化系统疾病中的意义
Qian-Rui Mi,Cai-Qian Wu,Cheng-Guo Lv et al.
Qian-Rui Mi et al.
The incidence of digestive system diseases is increasing, with liver diseases, obesity, inflammatory bowel disease (IBD), and hepatoenteric cancers being prominent contributors to global morbidity and mortality. Targeting farnesoid X recept...
Molecular basis for cross-activation of NPFF2R by a short PrRP-related peptide [0.03%]
短PrRP相关肽交叉激活NPFF2R的分子机制
Xin Li,Shuai Li,Hong Shan et al.
Xin Li et al.
Prolactin-releasing peptide (PrRP) is an endogenous ligand for the PrRPR, whose activation has been linked to anti-obesity effects. However, PrRP and its analogs also activate the neuropeptide FF receptor 2 (NPFF2R), which is associated wit...
VsNsbench: evaluating AlphaFold3-embed induced-fit mechanism for enhanced virtual screening [0.03%]
VsNsbench：评估AlphaFold3嵌入诱导契合机制以增强虚拟筛选效果
Shu-Kai Gu,Chao Shen,Yu-Wei Yang et al.
Shu-Kai Gu et al.
While AlphaFold3 (AF3) extends AlphaFold2 (AF2) by predicting holo structures, it remains unclear whether its modeling process captures similar induced-fit mechanisms. In this study, we benchmarked the VS performance of ligand-induced AF3 h...
Oridonin exerts dual therapeutic effects in MASLD mice by integrating lipid homeostasis and drug bioactivation via the LXRα-CES1/CES2 pathway [0.03%]
奥瑞甘素通过LXRα-CES1/CES2通路整合脂质稳态和药物生物活化在MASLD小鼠中发挥双重治疗作用
Huan-Guo Jiang,Zhi-Kun Zhan,Ling-Min Tian et al.
Huan-Guo Jiang et al.
Carboxylesterases CES1 and CES2 are the pivotal hepatic enzymes involved in triglyceride (TG) hydrolysis and prodrug metabolism, yet their expression and activity are suppressed in metabolic dysfunction-associated steatotic liver disease (M...