GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice [0.03%]
GATA3通过降低雄性小鼠海马CA3锥体神经元活性来驱动慢性压力引起的类似抑郁的行为
Yi-Qin Yao,Zhi-Yi Xu,Bo-Wei Guo et al.
Yi-Qin Yao et al.
GATA-binding protein 3 (GATA3), a member of the GATA transcription factor family crucial for cellular development and differentiation, is normally expressed at low levels in mature neurons. However, its pathophysiological role in the brain ...
Dendritic cell diversity and dysfunction in cancer: implications for immunotherapy and therapeutic targeting [0.03%]
树突细胞的多样性与功能障碍在癌症中的意义：对免疫治疗和靶向治疗的影响
Rong Wang,Yi Chen,Yan-Fen Fang
Rong Wang
Dendritic cells (DCs) comprise a heterogeneous population of specialized antigen-presenting cells that play central roles in the initiation and coordination of innate and adaptive immune responses. Recent advances in single-cell technologie...
Opportunities and challenges in the development of evolving EGFR inhibitors to overcome EGFR TKIs resistance [0.03%]
EGFR突变阳性非小细胞肺癌中克服TKIs耐药的“进化”EGFR抑制剂的发展机遇与挑战
Yi Chen,Qiu-Pei Liu,Si-Jie Yang et al.
Yi Chen et al.
Abnormal EGFR signaling is considered the cause of the occurrence and development of EGFR-addicted NSCLC. EGFR tyrosine kinase inhibitors (TKIs) have dramatically revolutionized the treatment landscape of NSCLC patients over the past two de...
Targeting USP8 with odoroside A regulates LXRβ-mediated fatty acid metabolic reprogramming against colorectal cancer [0.03%]
odoroside A靶向USP8调节LXRβ介导的脂肪酸代谢重编程对抗结直肠癌
Yan-Yan Chen,Fang-Fang Liu,Shi-Yuan Wen et al.
Yan-Yan Chen et al.
Colorectal cancer (CRC) remains a significant global health challenge, characterized by high post-surgical recurrence and poor survival outcomes. This study explores the therapeutic potential of odoroside A (OA), a natural compound derived ...
AAV-mediated GPR173 gene therapy attenuates long-term refractory epilepsy by enhancing synaptic GABAA receptor expression [0.03%]
AAV介导的GPR173基因治疗通过增强突触GABAA受体表达缓解难治性癫痫
Li-Yang Zhang,Yan-Yan Sun,Fei-Xu Jiang et al.
Li-Yang Zhang et al.
Approximately 30% of epilepsy patients are drug-resistant, and sustained seizure activity often reduces responsiveness to conventional therapies. This study aimed to evaluate the therapeutic efficacy and safety of adeno-associated virus (AA...
Structural basis for dual targeting of μ-opioid and nociceptin/orphanin FQ receptors by Cebranopadol [0.03%]
塞布拉诺帕朵尔同时作用于μ-阿片受体和孤儿素受体的结构基础研究
Ya-Li Lai,Xin-Yi Huang,Shi-Yi Shen et al.
Ya-Li Lai et al.
Cebranopadol is a first-in-class analgesic that combines agonism at the μ-opioid receptor (μOR) and the nociceptin/orphanin FQ receptor (NOPR), an approach proposed to improve the therapeutic index of opioid analgesia. Although Cebranopad...
Targeted protein degradation: bridging chemical biology and clinical translation [0.03%]
靶向蛋白质降解：连接化学生物学和临床转化
Yu-Bo Zhang,Jun-Wei Fu,Yue Liu et al.
Yu-Bo Zhang et al.
Traditional occupancy-driven pharmacology and emerging event-driven targeted protein degradation (TPD) play distinct roles in drug discovery. Although small-molecule inhibitors typically depend on sustained engagement of functional binding ...
Recent advances in the development of GRK2 inhibitors: blocking the interaction of GRK2 with its partners [0.03%]
近年GRK2抑制剂开发研究进展：阻断GRK2与其伙伴蛋白相互作用
Chen-Chen Han,Hao-Zhou Guo,Fu-Yuan Guo et al.
Chen-Chen Han et al.
G protein-coupled receptor kinase 2 (GRK2) is a key player in signal transduction and contains an N-terminus, a kinase domain (KD) and a C-terminus. Changes in the configuration of GRK2 regulate its allosteric effects, including KD closure ...
PYRIN m6A modification drives cardiomyocyte PANoptosis in sepsis-induced cardiomyopathy [0.03%]
脓毒症心肌病中PYRIN介导的m6A修饰驱动心肌细胞PANoptosis
He Sun,Xiang-Yan Peng,Meng-Meng Ye et al.
He Sun et al.
Sepsis-induced cardiomyopathy (SIC) is a major contributor to mortality in patients with sepsis, with PANoptosis-a form of inflammatory programmed cell death-emerging as a critical mechanism. This study investigated the upstream regulatory ...
Visible light reprograms MSCs and T cells into tumor-suppressive states via OPN4-mediated epigenetic remodeling [0.03%]
可见光通过OPN4介导的表观遗传重编程将MSC和T细胞转化为抑癌状态
Yin-Zhi Xu,Zhao-Yuan Xu,Uma K Aryal et al.
Yin-Zhi Xu et al.
Cellular metabolism critically influences tumor resistance. Biophysical stimulations such as mechanical vibration and electrical pulses can reprogram mesenchymal stem cells (MSCs) and T cells into tumor-suppressive states. Here, we investig...